Effects of a standardized Ayurvedic formulation on diabetes control in newly diagnosed Type-2 diabetics; a randomized active controlled clinical study

Awasthi, Harshika; Nath, Rajendra; Usman, Kauser; Mani, Dayanandan; Khattri, Sanjay; Nischal, Anil; Singh, Manju; Sawlani, Kamal Kumar

doi:10.1016/j.ctim.2015.06.005

Cited by 20 publications

(9 citation statements)

References 27 publications

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“…Patients received polyherbal capsules 500 mg/day, and the dose was increased weekly up to a maximum of 3 g/day or to a maximum of 2 g/day for metformin. After 24 weeks, reduction in FBG and HbA1c was similar for polyherbal formulation and metformin (Awasthi et al, ).…”

Section: Endocrinementioning

confidence: 82%

Berberine and barberry (Berberis vulgaris): A clinical review

Imenshahidi

Hosseinzadeh

2019

Phytotherapy Research

243

134

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Barberry (Berberis vulgaris L.) has different medicinal applications in folk medicine of Iran. Berberine, an alkaloid constituent of this plant, is present in the roots, rhizomes, stem, and bark of B. vulgaris and many other plants. There have been many clinical trials conducted that suggested a wide range of therapeutic applications. Here, we investigated the clinical uses of berberine and B. vulgaris in the treatment of different diseases in humans. An extensive search in electronic databases (PubMed, Scopus, Embase, Web of Sciences and Science Direct) was used to identify the clinical trials on B. vulgaris and berberine. Lipid‐lowering and insulin‐resistance improving actions are the most studied properties of berberine in numerous randomized clinical trials. There are also clinical trials regarding cardiovascular, anticancer, gastrointestinal, CNS, endocrine, and so on. Berberine has very low toxicity in usual doses and reveals clinical benefits without major side effects. Only mild gastrointestinal reactions may occur in some patients. The purpose of this review is to provide a summary concerning the clinical trials conducted on berberine to improve the clinical application of this nutraceutical in different diseases. In this review article, we used 77 clinical studies on human subjects.

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Section: Endocrinementioning

confidence: 82%

Berberine and barberry (Berberis vulgaris): A clinical review

Imenshahidi

Hosseinzadeh

2019

Phytotherapy Research

243

134

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“…Since the polyherbal formulation are able to reduce the postprandial blood glucose and Hb1Ac levels almost as effectively as metformin; and it seems to show more significant effect in high cholesterol management compared to metformin; hence, the use of this preparation maybe more useful for T2DM patients with hyperlipidemia since it has no side effects compared to metformin. 80 …”

Section: Herbal Remedy In Diabetesmentioning

confidence: 99%

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

340

192

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Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for medicinal purposes. Medicinal use of herbal medicine in the treatment and prevention of diseases including diabetes has a long history compared to conventional medicine. Diabetes is one of the major public health concerns over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazard; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes. There are various approaches to treat and prevent diabetes as well as its secondary complications, one of it is herbal medicines. However, the selection of herbs might depends on several factors, which include the stage of progression of diabetes, types of comorbidities that the patients are having, availability, affordability as well as the safety profile of the herbs. This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder – diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.

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“…Several Randomized controlled trials demonstrating a benefit on lipid parameters in diabetes include Ayurvedic polyherbal formulation [14], Hintonia latiflora [15] and magnesium [16]. In postmenopausal women with type 2 diabetes, vitamin D supplementation for 6 months reduced serum triglycerides (TG) without effect on other lipid parameters [17], while a meta-analysis with high heterogeneity showed benefit on lowering total cholesterol and TG [18].…”

Section: Thai Diabetic Patients Relied Mostly On a Modified Version Omentioning

confidence: 99%

Comparison and Effectiveness of Complementary and Alternative Medicine as against Conventional Medicine in the Treatment and Management of Type 2 Diabetes

Boston

Wong

Ganga

et al. 2019

JOCAMR

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Aim: The main objective of the study was to compare, using laboratory data, the efficacy of herbal medicines against conventional drugs in treating and managing diabetes mellitus (DM) among type 2 diabetic (T2DM) patients. Methodology: The study recruited 80 patients from a private Herbal Clinic and the Georgetown Public Hospital Diabetic and Medical Outpatient Clinic after giving their consent and satisfying the inclusion criteria. Laboratory tests and analysis were done using conventional scientific methods and data analyzed using SPSS version 20 with a p-value of 0.05 being used to determine statistical significance. Results: The results showed that age, religion, ethnicity, education, marital status and monthly income have significant associations with the use of herbs. Persons using herbal medicine alone had normal lipid profile, renal function and liver function test, in addition to hemoglobin (Hb), white blood cell count (WBC), glycosylated hemoglobin (HBA1c) and fasting blood glucose (FBS). The most common herbs used were Momordica charantia (local name- karela) and Azadirachta indica (local name- neem), which were used in combination or alone. Results showed a positive effect on coronary heart disease risk. Conclusion: The information generated from the study indicated that a significant number of diabetic patients using herbs alone for their treatment had normal results. However, a more controlled study is required to validate these results.

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Effects of a standardized Ayurvedic formulation on diabetes control in newly diagnosed Type-2 diabetics; a randomized active controlled clinical study

Cited by 20 publications

References 27 publications

Berberine and barberry (Berberis vulgaris): A clinical review

Berberine and barberry (Berberis vulgaris): A clinical review

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Comparison and Effectiveness of Complementary and Alternative Medicine as against Conventional Medicine in the Treatment and Management of Type 2 Diabetes

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