Comparative histocompatibility testing of seven calcium phosphate ceramics

Winter, M.B.; Griss, P.; Groot, K. de; Tagai, Hideo; Heimke, G.; Dijk, H.J.A. Van; Sawai, K.

doi:10.1016/0142-9612(81)90043-0

Cited by 129 publications

(49 citation statements)

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“…By contrast, there have been reports indicating that HA is both bioinert 36,37 and subject to biodegradation. 38,39 In our study the HA powder probably bonded to bone directly, but the HA powder directly apposed to newly formed bone was partially degraded. AW-GC powder on the cement surface reacted and directly bonded to bone through a Ca-P rich layer.…”

Section: Discussionmentioning

confidence: 92%

Bioactive bone cement: Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ?-tricalcium phosphate fillers on bone-bonding strength

Kobayashi

Nakamura

Okada

et al. 1998

J. Biomed. Mater. Res.

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A study was conducted to compare the bone-bonding strengths of three types of bioactive bone cement, consisting of either apatite- and wollastonite-containing glass-ceramic (AW-GC) powder, hydroxyapatite (HA) powder, or beta-tricalcium phosphate (beta-TCP) powder as an inorganic filler and bisphenol-a-glycidyl methacrylate (Bis-GMA) based resin as an organic matrix. Seventy percent (w/w) filler was added to the cement. Rectangular plates (10 x 15 x 2 mm) of each cement were made and abraded with #2000 alumina powder. After soaking in simulated body fluid for 2 days, the AW cement (AWC) and HA cement (HAC) formed bonelike apatite over their entire surfaces, but the TCP cement (TCPC) did not. Plates of each type of cement were implanted into the tibial metaphyses of male Japanese white rabbits, and the failure loads were measured by a detaching test at 10 and 25 weeks after implantation. The failure loads of AWC, HAC, and TCPC were 3.95, 2.04, and 2.03 kgf at 10 weeks and 4.36, 3.45, and 3.10 kgf at 25 weeks, respectively. The failure loads of the AWC were significantly higher than those of the HAC and TCPC at 10 and 25 weeks. Histological examination by contact microradiogram and Giemsa surface staining of the bone-cement interface revealed that all the bioactive bone cements were in direct contact with bone. However, scanning electron microscopy and energy-dispersive X-ray microanalysis showed that only AWC had contacted to the bone via a Ca-P rich layer formed at the interface between the AW-GC powder and the bone, which might explain its high bone-bonding strength. Neither the HAC nor the TCPC contacted the bone through such a layer between each powder and the bone, although the HAC and TCPC directly contacted with bone. Our results indicate that all three types of abraded and prefabricated cement have bonding strength to bone, but AWC has superior bone-bonding strength compared to HAC and TCPC.

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Section: Discussionmentioning

confidence: 92%

Bioactive bone cement: Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ?-tricalcium phosphate fillers on bone-bonding strength

Kobayashi

Nakamura

Okada

et al. 1998

J. Biomed. Mater. Res.

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“…The compressive strength was measured by an Instron 5567 Computerised Universal Testing Machine (Instron Corporation) under displacement controlled condition, with a displacement rate of 0.02-0.1 mm/min (based on the condition of the measured samples). Five samples were used for each compress testing and the dimension of samples used for compress testing was 10 3 10 3 20 mm 3 .…”

Section: Methodsmentioning

confidence: 99%

Porous nanoapatite scaffolds synthesized using an approach of interfacial mineralization reaction and their bioactivity

et al. 2014

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There is a growing interest in the use of calcium phosphate, used to fabricate porous scaffolds for bone tissue regeneration and repair. However, it is difficult to obtain interconnected pores with very high porosity and to engineer the topography of the pore walls for calcium phosphate ceramic scaffolds. In this study, a novelty method interfacial mineralization reaction was used to fabricate porous nano-calcium phosphate ceramic scaffolds with three-dimensional surface topography of walls, which was tuned using different surfactants; using this method, porous scaffolds with different shapes were obtained, which demonstrates that interfacial mineralization reaction is not only a good method to prepare porous ceramic scaffolds of calcium phosphate but also an efficient approach to engineer the topography of the pore walls. The as-prepared porous ceramic scaffolds have also been proved to have good biocompatibility, bioactivity, and biodegradability, which are necessary for the clinical application. In vivo experimental results revealed that not only osteoconduction but also osteoinduction was responsible for the bone formation in our scaffolds, which accelerated the formation of new bone, and that the degradation process of our porous scaffolds could match osteoinduction, mineralization of matrix and bone, and reconstruction of new bone very well, and porous scaffolds could be completely substituted by the new bone.

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“…Mechanical fixation of the implants was not increased to a significant level after 6 weeks' observation for the two doses investigated. Several different ceramic coatings have been developed to enhance bone ongrowth to implants: tricalcium phosphate, hydroxyapatite, and fluorapatite (Winter et al 1981, Klein et al 1991. These coatings have different physical and chemical properties which modify their biocompatibility in relation to bone (Klein et al 1983(Klein et al , 1991.…”

Section: Discussionmentioning

confidence: 99%

“…TCP ceramic coatings are readily resorbed in a physiological environment but have osteoconductive properties (Winter et al 1981, Klein et al 1991. HA is resorbed much more slowly than TCP, and thus provides much stronger implant fixation than TCP due to formation of a more stable implant-ceramic and ceramic-bone interface (Klein et al 1983, Tisdel et al 1994.…”

mentioning

confidence: 99%

Transforming growth factor-6 stimulates bone ongrowth: Hydroxyapatite-coated implants studied in dogs

Lind¹,

Overgaard²,

Nguyen³

et al. 1996

Acta Orthopaedica Scandinavica

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Comparative histocompatibility testing of seven calcium phosphate ceramics

Cited by 129 publications

References 0 publications

Bioactive bone cement: Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ?-tricalcium phosphate fillers on bone-bonding strength

Bioactive bone cement: Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ?-tricalcium phosphate fillers on bone-bonding strength

Porous nanoapatite scaffolds synthesized using an approach of interfacial mineralization reaction and their bioactivity

Transforming growth factor-6 stimulates bone ongrowth: Hydroxyapatite-coated implants studied in dogs

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