Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: A clinical and microbiological study

Anitha, Venugopal; Rajesh, P; Shanmugam, M; Priya, B Meena; Prabhu, Shivananda; Shivakumar, V

doi:10.4103/0970-9290.156806

Cited by 59 publications

(46 citation statements)

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“…Antiseptic solutions are routinely used in the dento-maxillofacial field for a variety of procedures including pre- and postoperative rinses [ 5 ], conservative treatment for osteonecrosis of the jaw [ 6 , 7 ], relieving treatment for oral mucositis [ 8 ], irrigation of extraction sockets [ 9 , 10 ], in the field of periodontology as antibacterial mouth rinses [ 11 ], irrigation of dental implants [ 12 , 13 ], and for the treatment and management of advanced cases of periodontitis [ 14 , 15 , 16 ]. Based on their widespread use, it becomes pivotal that their effect on soft and hard tissue healing is uneventful and that their interface with cells of the oral cavity is favorable.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Gene Expression Changes of a Novel Homeopathic Antiseptic Oral Rinse in Comparison to Chlorhexidine in Gingival Fibroblasts

et al. 2020

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Most available antiseptic solutions available today have strong antibacterial effects, however most also possess major cytotoxic effects on human gingival tissues. The VEGA Oral Care Recovery Kit (StellaLife), previously evaluated in clinical studies, consists of 16 active ingredients that are monographed in the Homeopathic Pharmacopeia of United States (HPUS) and recognized for their accelerated healing properties (reduction in post-op pain). The aim of this study was to compare VEGA to chlorhexidine (CHX) in vitro on gingival fibroblast viability, survival at various concentrations, migration assay, proliferation activity, expression of both regenerative growth factors as well as inflammatory markers, and collagen synthesis. A 10-fold dilution of standard CHX (0.02%) led to cell death, whereas cell viability was significantly better in the VEGA group for all tested parameters. Furthermore, VEGA also induced significantly greater fibroblast migration and proliferation. CHX negatively impacted the cellular inflammatory response of gingival fibroblasts, and also led to a reduction in collagen synthesis (50% decrease). Findings from the present study provide support from basic laboratory experiments that validate the previous clinical studies supporting the use of the VEGA oral rinse on its superior biocompatibility and wound healing properties when compared to CHX.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Gene Expression Changes of a Novel Homeopathic Antiseptic Oral Rinse in Comparison to Chlorhexidine in Gingival Fibroblasts

et al. 2020

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“…Additionally, in a clinical trial of 30 patients comparing 1% curcumin gel and 0.1% chlorhexidine gel application, following SRP, significant improvement in the clinical parameters as well as reduction of the colony-forming units was reported in both groups. However, more significant reduction was noted in the curcumin group and the authors recommended its use over chlorhexidine, especially because of its minimal side effects [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1β, and TNF-α in Chronic Periodontitis Patients

Mohammad

2020

BioMed Research International

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Curcumin exhibits antibacterial, antioxidant, and anti-inflammatory effects and has been suggested as a treatment for inflammatory diseases. The study is aimed at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc, copper, and magnesium) and proinflammatory cytokines (IL-1β and TNF-α) in chronic periodontitis patients. Ninety subjects with an age of 25-54 were included in this study. From the total number, 30 subjects with healthy periodontium (control group) ( mean age = 37.30 ± 7.08 ) were employed for the sole purpose of obtaining the normal mean values of clinical, chemical, and immunological parameters, and 60 with chronic periodontitis ( mean age = 36.73 ± 6.22 ) were divided randomly into 2 groups, of which each group included 30 subjects. Group A received scaling and root planing SRP and curcumin gel injection covered by Coe pack for 7 days, and group B received SRP alone covered by Coe pack. Clinical parameters (plaque index, gingival index, bleeding on probing, pocket depth, and clinical attachment loss measurements) and blood samples were collected before and after 1 month of treatment to measure serum levels of zinc, copper, magnesium, IL-1β, and TNF-α. The results showed significant micronutrient alteration and increase of proinflammatory cytokines in the chronic periodontitis group as compared to healthy control ( P ≤ 0.05 ), and curcumin gel had a significant effect on the reduction of IL-1β, TNF-α, copper, and clinical parameters ( P ≤ 0.05 ) and increase of zinc and magnesium levels after 1 month as compared to baseline ( P ≤ 0.05 ), nearly the same pattern for group B but with nonsignificant differences for Zn ( P > 0.05 ). In conclusion, curcumin gel resulted in a more significant reduction in clinical parameters, inflammatory mediators, and copper and increase of zinc and magnesium levels as compared to SRP alone.

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“…If PD induced by P. gingivalis or other pathogens is a key factor participating in the loss of tolerance that characterizes early RA [ 85 , 89 , 91 , 94 , 104 , 107 , 115 , 116 ], a key preventive measure would be efficient treatment of PD, i.e., infection by P. gingivalis or other PD-related oral pathogens ( Figure 1 ). To this end, lessons must be learned from the work performed on this topic by researchers in the past [ 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 ].…”

Section: Prevention Of Early Ra: Fighting Periodontitismentioning

confidence: 99%

“…Amongst polyphenols, both curcumin and quercetin are able to alter the architecture of mature multi-species biofilms; however, only curcumin-treated biofilms display significantly reduced metabolic activity [ 132 ]. Local curcumin was clinically effective and reduced the microbial load in patients with chronic PD [ 124 ].…”

Section: Prevention Of Early Ra: Fighting Periodontitismentioning

confidence: 99%

Curcumin for the Management of Periodontitis and Early ACPA-Positive Rheumatoid Arthritis: Killing Two Birds with One Stone

et al. 2018

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We propose curcumin as a preventive measure to avoid/manage periodontitis (PD), and as a natural immunosuppressant for rheumatoid arthritis (RA). PD, mainly caused by Porphyromonas gingivalis forming biofilm and leading to tooth decay, is a major public health issue and a risk factor for the development of RA in humans. P. gingivalis is able to trigger experimental autoimmune arthritis in animal models and in humans can induce citrullinated peptides, which not only are a source of anti-citrullinated antibodies (ACPAs), but also participate in autoreactive responses and disease development. Curcumin appears to have efficient anti-bacterial activity against P. gingivalis infection and biofilm formation. In addition to antibacterial, anti-oxidant, and anti-inflammatory action, curcumin exerts unique immunosuppressant properties via the inhibition of Th17 pro-inflammatory responses and promotion of regulatory T cells, thus suppressing autoimmunity. We introduce curcumin as a natural product for the management of both PD and RA-related autoreactivity, possibly also as a preventive measure in early RA or individuals at high risk to develop RA.

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Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: A clinical and microbiological study

Abstract: Although curcumin has equivalent benefit to chlorhexidine, curcumin being an ayurvedic herb is an excellent alternative to chlorhexidine due to minimal side-effects.

Cited by 59 publications

References 0 publications

Cytotoxicity and Gene Expression Changes of a Novel Homeopathic Antiseptic Oral Rinse in Comparison to Chlorhexidine in Gingival Fibroblasts

Cytotoxicity and Gene Expression Changes of a Novel Homeopathic Antiseptic Oral Rinse in Comparison to Chlorhexidine in Gingival Fibroblasts

Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1β, and TNF-α in Chronic Periodontitis Patients

Curcumin for the Management of Periodontitis and Early ACPA-Positive Rheumatoid Arthritis: Killing Two Birds with One Stone

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