Comparative Analysis of the Measles Antibody Levels in Healthy Medical Personnel of Maternity Ward and Women in Labor

Abstract

It has been proven that post-vaccination immunity to measles virus after two doses of vaccine is not able to persistently protect against infection throughout life. The goal of this research was to determine the immune layer to the measles virus among women in labor and maternity ward personnel in the same medical institution. The levels of IgG antibodies to measles virus in the umbilical cord blood of 594 women in labor and 88 workers of the maternity ward were studied by ELISA. It was revealed that 22.7% of umbilical cord blood serum samples from parturient women and 21.4% of blood serum samples from maternity ward personnel were seronegative (<0.18 IU/ml). Levels of IgG antibodies to measles virus in low values (<1.0 IU/ml) were detected in 67% of blood serum samples among women in labor and 68.9% among employees of the maternity ward. Among women in labor, women under 35 years of age are at the highest risk of contracting measles; the proportion of women with low levels of protective antibodies in this age group was almost 70%, and the proportion of women without protective levels of antibodies was 23%. Compared with the age group 36–43, the age of women in labor under 35 was associated with a higher chance of not having immune protection against infection with measles virus OR [95% CI] = 2.2 [1.1–4.5] (p = 0.02) or had a low level of protection OR [95% CI] = 1.9 [1.2–3.0] (p = 0.001). It was also found that among women over 35 years of age, the proportion of persons with a high level of antibodies in women in labor was statistically significantly higher than among members of the maternity ward staff (13 and 0%, respectively, p = 0.007). Thus, maternity ward employees and women in labor constitute a risk group for measles due to the presence of a high proportion of seronegative persons among women of childbearing age (both maternity ward employees and women in labor). These conditions create the need to revise current approaches to present vaccination procedures, especially in the current epidemiological situation with COVID-19.

Intelligent system based comparative analysis study of SARS-CoV-2 spike protein and antigenic proteins in different types of vaccines

“…Different researchers prove that the Sars-Cov-2 genome is the result of the recombination between two beta-coronavirus genomes: Pangolin and Bat coronavirus [ 7 , 8 , 29 , 30 ]. Various in silico studies search for the effect of the vaccination, especially with pneumococcal vaccines, to protect against symptomatic cases of SARS-CoV-2 infection and death [ 31 – 36 ]. Our main objective was to find similar amino-acid sequences in the S protein of the Sars-Cov-2 genome and the investigated proteins sequences mentioned above using the recombination between bioinformatics and signal processing tools.…”

Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021

“…The Vector-Best IgG-measles test system (Russia) was used in a study [62] to investigate the level of immunity to the measles virus in women in labor and staff of maternity hospitals in one medical institution. It was shown that the studied contingent is a risk group for measles due to the high proportion of seronegative individuals among women of childbearing age (both maternity hospitals' personnel and women in labor).…”