Combined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study

Gonçalves, Francyenne Maira Castro; Delbem, Alberto Carlos Botazzo; Gomes, Leonardo Fernandes; Emerenciano, Nayara Gonçalves; Silva, Matheus dos Passos; Cannon, Mark; Danelon, Marcelle

doi:10.1007/s00784-020-03597-7

Cited by 11 publications

(15 citation statements)

References 41 publications

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“…The current study evaluated the role of CPP‐ACP in the remineralization of early enamel lesions after 24 months of daily use. The results of the current study are in line with the findings of recently published laboratory and clinical studies 24,25,27,29 …”

Section: Discussionsupporting

confidence: 92%

“…Also, the lesions size has been decreased (Figure 4). Calcium and phosphate ions released from CPP‐ACP can form nanocomplex in the oral biofilm surrounding enamel lesion 29 . This can provide a state of supersaturation of minerals that can reharden the softened enamel and induce hydroxyapatite formation 29 …”

Section: Discussionmentioning

confidence: 99%

“…It was demonstrated that CPP has a relatively low dissociation effect on calcium phosphate 28 . This means CPP can increase the bioavailability of calcium and phosphate ions and this consequently enhances the remineralization process 28,29 …”

Section: Introductionmentioning

confidence: 99%

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Long‐term evaluation of early‐enamel lesions treated with novel experimental tricalcium silicate paste: A 2‐year randomized clinical trial

Hamdi

Hamama

Motawea

et al. 2022

J Esthet Restor Dent

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Objective: The aim of the current study is to evaluate the remineralization potential of experimental tricalcium silicate (TCS) paste in comparison with more popular remineralizing agents like silver diamine fluoride potassium iodide (SDF-KI) and casein phosphopeptide amorphous calcium phosphate (CPP-ACP) on early enamel lesions.Materials and Methods: Forty-five patients in the age range of 15-50 years had early enamel lesions on the buccal surface of molar teeth. The patients were randomly divided into three treatment groups (SDF-KI, CPP-ACP, and TCS group) with 15 patients per group. Lesions were evaluated clinically by DIAGNOdent pen immediately and after 3,6,12, and 24 months of treatment. Results:The study was completed with 45 patients and 92 teeth. Twice-daily application of CPP-ACP and TCS paste showed a significant remineralization effect on early enamel lesions after 24 months (p < 0.001). Also, annual application of SDF-KI showed a significant remineralization effect after 24 months (p < 0.001). There was a significant difference between (SDF-KI and CPP-ACP) and (SDF-KI and TCS) at the different follow-up periods 3,6,12, and 24 months (p < 0.001). Meanwhile, there was no significant difference between CPP-ACP and TCS at the mentioned follow-up periods (p > 0.05). Conclusion: TCS showed potential remineralization for early enamel lesions.Clinical Relevance: Experimental TCS is a promising remineralizing agent for management of early enamel lesions.casein phosphopeptide amorphous calcium phosphate, DIAGNOdent pen, enamel, experimental tricalcium silicate, remineralization, silver diamine fluoride potassium iodide | INTRODUCTIONEarly enamel lesion is a reversible non cavitated progressive disease that results from acidic attacks produced by cariogenic bacteria. The disease is considered a major public health problem in different countries. With a better understanding of the oral environment, the management of such lesions has been directed toward conservative approaches. Undoubtedly, early caries detection is an important factor that can limit the prevalence of the disease and reduce the burden of future treatment. 1 Early detection of subtle changes in enamel via

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Long‐term evaluation of early‐enamel lesions treated with novel experimental tricalcium silicate paste: A 2‐year randomized clinical trial

Hamdi

Hamama

Motawea

et al. 2022

J Esthet Restor Dent

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“…The results indicated that all the three remineralizing agents had a significant remineralization effect on initial caries. The efficacy of ionic fluoride in toothpaste has been confirmed in recent in vitro studies [19][20][21] and is supported by in vivo studies [22][23][24] . To date, the most effective remineralizing agent is fluoride.…”

Section: Resultsmentioning

confidence: 72%

Effects of Homemade Nano-Hydroxyapatite and Olive Oil Paste on Remineralization of Early Caries Lesions

et al. 2022

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Nano-hydroxyapatite (nHAP) particles are a new generation of materials reported to remineralize enamel lesions. The purpose we aimed was to compare the in vitro effects of fluoride gel, sodium fluoride toothpaste, and homemade nHAP paste on remineralizing artificial early enamel caries. Methods: Incipient caries were induced in 21 extracted, sound premolar teeth by storing each specimen in a demineralization solution for 72 hours, followed by pH cycling. The samples (n= 7, each) were then treated with 2% neutral fluoride gel, 0.25% sodium fluoride toothpaste, or homemade nHAP paste, comprising a mixture of nHAP powder and olive oil. After demineralization and remineralization, the results were compared using the DIAGNOdent pen (KaVo, Germany). The data were statistically analyzed using paired t-tests and a one-way ANOVA test. Outcomes: The degree of demineralization in each of the three groups (fluoride gel group, 15.71; sodium fluoride dentifrice group, 15.28; nHAP paste group, 16.71) was significantly elevated compared to baseline (3, 2.5, 2.28, respectively); however, no significant difference was observed between the remineralization readings in each of the three groups (6, 7, 5.5, respectively) (p > 0.05). In conclusion, we concluded that the homemade nHAP paste had a beneficial effect on the remineralization of initial enamel caries lesions.

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“…The present study contributes to a better understanding of the mechanism of action of TMP and CaGP under in vitro [Takeshita et al, 2011;Zaze et al, 2014;de Castro et al, 2015;Danelon et al, 2017;Gonçalves et al, 2021] and in situ [ do Amaral et al, 2013;Takeshita et al, 2015;Takeshita et al, 2016;Emerenciano et al, 2018] conditions. However, the results should be carefully evaluated, since the model did not factor in the presence of saliva.…”

Section: Abmentioning

confidence: 88%

Surface Free Energy, Interaction, and Adsorption of Calcium and Phosphate to Enamel Treated with Trimetaphosphate and Glycerophosphate

et al. 2021

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This study aimed to evaluate the surface (γ s ) and interaction (ΔG iwi ) free energy and calcium (Ca 2+ ) and phosphate (PO 4 3− ) adsorption to dental enamel treated with sodium trimetaphosphate (TMP) or calcium glycerophosphate (CaGP) that had or had not been exposed to CaPO 4 -containing solutions. Bovine enamel blocks (n = 192; 24 blocks/group) were treated (2 mL/block; 2 min) with TMP (0%, 1%, 3%, and 9%) and CaGP (0, 0.25, 0.5, and 1%) or exposed to a CaPO 4 -containing solution. The adsorption of these compounds by enamel was assessed before and after treatment. γ s and ΔG iwi and their apolar (γ s LW and ΔG iwi LW ) and polar (γ s AB and ΔG iwi AB ) components and acid-base interactions (γ s + /γ s − ) were determined by the contact angles. The data were subjected to ANOVA, followed by the Student-Newman-Keuls test (p < 0.05). The adsorption of TMP was dose dependent (p < 0.001), and it reduced γ s and γ s AB and increased ΔG iwi AB (ΔG iwi > 0) and γ s − when compared with the group without TMP (p < 0.001). The immersion in CaPO 4 -containing solu-tion increased γ s and γ s AB and reduced ΔG iwi AB (ΔG iwi > 0) and γ s − (p < 0.001). There was a correlation between the adsorption of TMP and Ca 2+ (r = 0.916; p < 0.001) and PO 4 3− (r = 0.899; p < 0.001). The adsorption of CaGP on the enamel was dose dependent (p < 0.001), reducing γ s , ΔG iwi AB (ΔG iwi < 0), γ s LW , and γ s − when compared to the group without CaGP (p < 0.001). When exposed to the CaPO 4 -containing solution, there was an increase in ΔG iwi AB (ΔG iwi > 0), γ s LW , and γ s − and a decrease in γ s AB (p < 0.001) without adsorption of Ca 2+ by enamel. It may be concluded that TMP and CaGP were adsorbed onto the enamel, producing hydrophilic and hydrophobic surfaces, respectively. TMP produces electron donor sites that induce Ca 2+ adsorption, while CaGP releases Ca 2+ into the medium.

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Combined effect of casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate on the prevention of enamel demineralization and dental caries: an in vitro study

Cited by 11 publications

References 41 publications

Long‐term evaluation of early‐enamel lesions treated with novel experimental tricalcium silicate paste: A 2‐year randomized clinical trial

Long‐term evaluation of early‐enamel lesions treated with novel experimental tricalcium silicate paste: A 2‐year randomized clinical trial

Effects of Homemade Nano-Hydroxyapatite and Olive Oil Paste on Remineralization of Early Caries Lesions

Surface Free Energy, Interaction, and Adsorption of Calcium and Phosphate to Enamel Treated with Trimetaphosphate and Glycerophosphate

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