Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens

Ma, Xiuling; Bi, Shicheng; Wang, Y.; Chi, Xiaoqing; Hu, Songhua

doi:10.3382/ps/pez207

Cited by 60 publications

(50 citation statements)

References 33 publications

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“…37 It was reported that synergistic effect of selenium with ginseng stem-leaf saponins could induce immune response to a live bivalent infectious bronchitis coronavirus vaccine in chickens. 40 Therefore, selenium supplementation could be an effective choice for the treatment of this novel virus of COVID-19.…”

Section: Seleniummentioning

confidence: 99%

“…Baicalin was also found to have the ability to inhibit SARS-CoV in vitro 50. Ginseng stem-leaf saponins could highly enhance the specific-antibody responses for Newcastle disease virus and infectious bronchitis virus 40. Therefore, ChineseMedicine could also be considered as a choice to enhance host immunity against the infection of COVID-19.In summary, the general treatment for viral infection including nutritional interventions and all kinds of immunoenhancers has been used to enhance host immunity against RNA viral infections.…”

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confidence: 97%

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Potential interventions for novel coronavirus in China: A systematic review

Zhang

Liu

2020

Journal of Medical Virology

1,148

1,178

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An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. We suggest that the nutritional status of each infected patient should be evaluated before the administration of general treatments and the current children's RNA-virus vaccines including influenza vaccine should be immunized for uninfected people and health care

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Section: Seleniummentioning

confidence: 99%

mentioning

confidence: 97%

Potential interventions for novel coronavirus in China: A systematic review

Zhang

Liu

2020

Journal of Medical Virology

1,148

1,178

View full text Add to dashboard Cite

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“…Selenium, along with ginseng saponins, has been reported to lead to the upregulation of the reaction to a live infectious coronavirus vaccine against avian coronavirus (IBV) in chickens [ 59 ]. A recent study showed that selenium plays a particular role in ACE inhibition, suggesting its beneficial role against COVID-19 [ 60 ].…”

Section: Minerals and Immune Systemmentioning

confidence: 99%

Effective Immune Functions of Micronutrients against SARS-CoV-2

et al. 2020

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The third coronavirus outbreak in the last two decades has caused significant damage to the world’s economy and community health. The highly contagious COVID-19 infection has affected millions of people to date and has led to hundreds of thousands of deaths worldwide. Aside from the highly infectious nature of SARS-CoV-2, the lack of a treatment or vaccine has been the main reason for its spread. Thus, it has become necessary to find alternative methods for controlling SARS-CoV-2. For the present review, we conducted an online search for different available nutrition-based therapies for previously known coronavirus infections and RNA-based virus infections as well as general antiviral therapies. These treatments have promise for combating COVID-19, as various nutrients and minerals play direct and indirect roles in the control and prevention of this newly emerged viral infection. The patients’ nutritional status with COVID-19 must be analyzed before administering any treatment, and nutritional supplements should be given to the affected individuals along with routine treatment. We suggest a potential interventional role of nutrients to strengthen the immune system against the emerging infection caused by COVID-19.

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“…Three types of oil emulsion including O/W, W/O, and water in oil in water can be formed depending on the ratio of oil and aqueous phases and the surfactants used. It was reported that the W/O emulsion showed more potent adjuvant on vaccines against the avian influenza virus, infectious bronchitis virus, or NDV than O/W or water-in-oil-in-water emulsion in chickens ( Jansen et al., 2006 ; Lone et al., 2017 ). The reason is because W/O emulsion sustainably releases the antigen to stimulate the lymph tissues from the vaccine depot at the injection sites ( Spickler and Roth, 2003 ; Bonam et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…When infected with the NDV, the chickens show clinical signs such as reduction in egg production, respiratory distress, listlessness, central nervous signs, and even death, causing huge amount of economic losses to the poultry industry ( Kapczynski et al., 2013 ). Vaccination is one of the conventional approaches to the control of the disease ( Kiril et al., 2017 ; Ma et al., 2019 ). To improve the immunization, inactivated NDV vaccine is usually supplemented with adjuvants, and the vaccine is usually made from emulsification of an aqueous phase containing antigen with an adjuvant oil phase.…”

Section: Introductionmentioning

confidence: 99%

Sunflower seed oil containing ginseng stem–leaf saponins (E515-D) is a safe adjuvant for Newcastle disease vaccine

Wang

et al. 2020

Poultry Science

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Vaccination is an effective method to prevent Newcastle disease ( ND ) in chickens. Marcol 52 and #10 white oil are mineral-based adjuvants and can be found in commercial inactivated ND virus vaccines. The present study demonstrated that a vegetable origin oil E515-D had lower polycyclic aromatic hydrocarbons and higher flash point than the commercial products Marcol 52 and #10 white oil. E515-D could be mixed with an aqueous phase containing ND virus antigen to form a stable water-in-oil vaccine emulsion and exhibited more potent adjuvant effects on the immune response than Marcol 52 and #10 white oil. Moreover, the absorption of E515-D–adjuvanted vaccine was faster than absorption of Marcol 52- and #10 white oil-adjuvanted vaccines when ND virus vaccines were injected in broilers. Therefore, E515-D was safe and could be a suitable adjuvant used in vaccines for food animals. In addition，E515-D is not easy to be flammable during shipping and storage owing to its higher flash point.

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Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens

Cited by 60 publications

References 33 publications

Potential interventions for novel coronavirus in China: A systematic review

Potential interventions for novel coronavirus in China: A systematic review

Effective Immune Functions of Micronutrients against SARS-CoV-2

Sunflower seed oil containing ginseng stem–leaf saponins (E515-D) is a safe adjuvant for Newcastle disease vaccine

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