Potential interventions for novel coronavirus in China: A systematic review

Zhang, Lei; Liu, Yunhui

doi:10.1002/jmv.25707

Cited by 1,149 publications

(1,355 citation statements)

References 139 publications

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“…RNA virus related vaccines, including measles, polio, encephalitis B virus and influenza virus, could be the most promising alternatives. And interpersonal transmission of the virus could be prevented by immunizing health care workers and non-infected population [66].…”

Section: Prevention Of Sars-cov-2mentioning

confidence: 99%

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

Wang

et al. 2020

International Journal of Antimicrobial Agents

978

815

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Section: Prevention Of Sars-cov-2mentioning

confidence: 99%

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

Wang

et al. 2020

International Journal of Antimicrobial Agents

978

815

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“…Currently, no effective antiviral therapy for COVID-19 was confirmed (Zhang and Liu, 2020) . Interferon-α, Lopinavir/Ritonavir and Arbidol were used according to previous experience, however, there's a lack of evidence of unified treatment plan.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

Zhang¹,

Cai²,

Hu³

et al. 2020

International Journal of Infectious Diseases

265

240

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J o u r n a l P r e -p r o o f 2 (Lanjuan Li); yidayang65@zju.edu.cn (Yida Yang) Highlight  COVID-19 has be a great threat to world health.  We aim to investigate clinical features of patients with abnormal imaging findings.  Those with abnormal images have more obvious clinical and laboratory features.  Combing clinical data with imaging score can predict severe/critical type. AbstractPurpose: To investigate the epidemiological, clinical characteristics of COVID-19 patients with abnormal imaging findings. Methods: Patients confirmed with SARS-CoV-2 infection of Zhejiang province fromJan 17 to Feb 8 underwent CT or x-ray were enrolled. Epidemiological, clinical data were analyzed between those with abnormal or normal imaging findings.Results: Excluding 72 patients with normal images, 230 of 573 patients affected more than two lobes. The median radiograph score was 2.0 and there's negative correlation between the score and oxygenation index (ρ=-0.657, P<0.001). Patients with abnormal images were older (46.65±13.82), with higher rate of coexisting condition(28.8%), lower rate of exposure history and longer time between onset and confirmation(5d) than non-pneumonia patients(all P<0.05). Higher rate of fever, cough, expectoration, and headache, lower lymphocytes, albumin, serum sodium levels and higher total bilirubin, creatine kinase, lactate dehydrogenase and C-reactive J o u r n a l P r e -p r o o f 3 protein levels and lower oxygenation index were observed in pneumonia patients (all P<0.05). Muscle ache, shortness of breath, nausea and vomiting, lower lymphocytes levels and higher serum creatinine and radiograph score at admission were predictive factors for severe/critical subtype. Conclusion:Patients with abnormal images have more obvious clinical manifestations and laboratory changes. Combing clinical features and radiograph score can effectively predict severe/critical type.

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“…CR3022, a SARS coronavirus-specific human monoclonal antibody, can bind potently with the receptor-binding domain(RBD) of SARS-CoV-2 and has the potential to be developed as candidate therapeutics of SARS-CoV-2 infections [71]. Other monoclonal antibodies neutralizing SARS-CoV, such as m396, CR3014, could be an alternative for the treatment of SARS-CoV-2 [72].…”

Section: Antibody and Plasma Therapymentioning

confidence: 99%