Coexistence of choriocarcinoma and adenocarcinoma in the rectum: Molecular aspects

Abstract

Choriocarcinoma, a malignant tumor of usually placental origin, in divided into two groups; the gestational and non-gestational types, the latter being rare. Non-gestational choriocarcinoma occurs in the lung, mediastinum, kidney, stomach, and small intestine, but rarely appears in the large intestine. We treated a 29-year-old woman with choriocarcinoma of the rectum with adenocarcinoma. Despite the rarity of the condition and the obscurity of the histogenesis, reports of similar cases and the occurrence of the tumors in the digestive tract suggest that the condition constitutes a clinical entity of a digestive tumor.

Rectal adenocarcinoma with choriocarcinomatous differentiation: Clinical and genetic aspects

“…They occur in the gastrointestinal tract, with tumors described in the esophagus, stomach, small intestine, colon, rectum, and the gall bladder, as well as in the urinary tract and the lung. [1][2][3][4][5][6][7][8] Histologically a biphasic tumor growth with adenocarcinomatous or transitional cell carcinomatous parts, depending on the originating site, and choriocarcinomatous parts is a recurrent finding. 5 Clinically, these tumors show an aggressive behavior.…”

“…[1][2][3][4][5][6][7][8] Histologically a biphasic tumor growth with adenocarcinomatous or transitional cell carcinomatous parts, depending on the originating site, and choriocarcinomatous parts is a recurrent finding. 5 Clinically, these tumors show an aggressive behavior. Most reported patients died of rapidly progressive hepatic and pulmonary metastasis before chemotherapy could be initiated.…”

Primary Choriocarcinoma of the Jejunum: Report of a Case

“…This theory is supported by other reports in which elements of both choriocarcinoma and adenocarcinoma were observed simultaneously in the same tumor. 20 No element of adenocarcinoma was found in the tumor from our patient, but we speculate that the rapid growth of the choriocarcinomatous element expelled the adenocarcinoma, as described by Ordonez and Luna. 21 The characteristic symptoms of choriocarcinoma in the small intestine, whether primary or secondary, are massive melena and severe anemia.…”

Choriocarcinoma of the sigmoid colon: report of a case

“…Nongestational, extragonadal choriocarcinoma is rare, but is occasionally found in the digestive tract, most frequently in the stomach. Primary choriocarcinoma of the colon is extremely rare, with only eight cases documented in the world literature (Table 1) [1][2][3][4][5][6][7][8]. These patients, including ours, consisted of three men and six women, with an average age of 51.6 years (range 29-74 years).…”

“…Chemotherapy is an important part of treatment because radiation and local treatment are thought to be ineffective against choriocarcinoma, which is characterized by rapid proliferation with generalized metastasis. In fact according to one report, chemotherapy for choriocarcinoma, rather than adenocarcinoma of the large intestine, was the key to prolonging survival [6]. Another report stated that survival was Fig.…”