Choriocarcinoma of the sigmoid colon: report of a case

Harada, Mikihiko; Inoue, Takashi; Hamano, Kimikazu

doi:10.1007/s00595-011-0026-3

Cited by 17 publications

(21 citation statements)

References 11 publications

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“…A possible explanation for this differential therapeutic response may be due to different variants of colorectal choriocarcinoma ranging from mixed tumors with a component of conventional intestinal adenocarcinoma to pure trophoblastic neoplasia (14, 24). Interestingly, a combined treatment regimen targeting both components has previously shown efficacy in a case of mixed colorectal choriocarcinoma leading to long-term disease-free survival of 60 months (25). This suggests that histological tumor composition could be a potential indicator of treatment response.…”

Section: Discussionmentioning

confidence: 99%

Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome

Koelzer

Steuer²,

Gross

et al. 2016

Front. Oncol.

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BackgroundPersonalized therapy of colorectal cancer is influenced by morphological, molecular, and host-related factors. Here, we report the comprehensive clinicopathological and molecular analysis of an extra-gestational colorectal choriocarcinoma in a patient with probable Lynch syndrome.Case presentationA 61-year-old female with history of gastric cancer at age 36 presented with a transmurally invasive tumor of the right hemicolon and liver metastasis. A right hemicolectomy was performed. Histopathological analysis showed a mixed trophoblastic and syncytiotrophoblastic differentiation, consistent with choriocarcinoma. Disease progression was rapid under oxaliplatin, capecitabine, irinotecan, and bevacizumab. Molecular phenotyping identified loss of mismatch-repair protein immunostaining for PMS2, microsatellite instability, a lack of MLH1 promoter methylation, and lack of BRAF mutation suggestive of Lynch syndrome. Targeted next-generation sequencing revealed an ataxia telangiectasia mutated (p.P604S) missense mutation. A bleomycin, etoposide, and cisplatin treatment protocol targeting germ cell neoplasia lead to disease remission and prolonged survival of 34 months.ConclusionComprehensive immunohistochemical and genetic testing is essential to identify uncommon cancers possibly related to Lynch syndrome. For rare tumors, personalized therapeutic approaches should take both molecular and morphological information into account.

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Section: Discussionmentioning

confidence: 99%

Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome

Koelzer

Steuer²,

Gross

et al. 2016

Front. Oncol.

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“…Choriocarcinoma of extragenital origin has been reported in the retroperitoneum [1], mediastinum [2], and intracalvarium (especially in the pineal gland [3]). When it occurs in the gastrointestinal tract, the stomach is the most common site [4]. PCC originating in the colon is extremely rare, with only 12 documented cases.…”

Section: Discussionmentioning

confidence: 99%

“…Several hypotheses have been proposed, including that it develops from retained primordial germ cells that migrated abnormally during embryonic development [16]; metastasis from a latent primary lesion in the genitalia [4]; and the retrodifferentiation of pre-existing colonic carcinoma [8]. Among them, the retrodifferentiation theory from pre-existing colonic adenocarcinoma is well accepted.…”

Section: Discussionmentioning

confidence: 99%

“…For patients with widespread metastasis, resection has proven ineffective in prolonging survival. In patients without metastasis, a combination of radical surgery and appropriate adjuvant chemotherapy contributed to their long-term survival [4]. The chemotherapy modality for primary extragenital choriocarcinoma has not been established; most treatment options are based on experience.…”

Section: Discussionmentioning

confidence: 99%

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Primary choriocarcinoma of the colon: a case report and review of the literature

Jiang

Peng

2013

World J Surg Onc

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Choriocarcinoma usually arises in the uterus and gonads. Primary choriocarcinoma (PCC) in an extragenital organ is rare. When it occurs in the gastrointestinal tract, the stomach is the most common site. Only 12 cases of PCC of the colon have been reported in the world literature. Most cases were associated with adenocarcinoma. We report the case of a 36-year-old man with PCC of the colon and review the clinical characteristics of previously documented cases.

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“…A choriocarcinomatous component is rarely present in carcinomas of certain sites, including the lung (1), breast (2), esophagus (3), stomach (4,5), colon (6,7) and urinary system (8). Furthermore, uterine corpus carcinomas with choriocarcinomatous differentiation have rarely been reported (9–17).…”

Section: Introductionmentioning

confidence: 99%

Endometrioid adenocarcinoma with choriocarcinomatous differentiation: A case report and review of the literature

Ishida¹,

Okabe²

2013

Oncology Letters

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A choriocarcinomatous component is rarely present in carcinomas of certain sites and few cases of choriocarcinomatous differentiation in endometrioid adenocarcinoma have been reported. The present study reports a case of endometrioid adenocarcinoma of the uterine corpus with choriocarcinomatous differentiation, and discusses the clinicopathological features of this rare tumor. A 59-year-old post-menopausal female presented with abnormal vaginal bleeding. Magnetic resonance imaging demonstrated a relatively well-circumscribed tumor in the uterine corpus and a total cystectomy was subsequently performed. A histopathological examination revealed two distinct components in the uterine corpus tumor. The first component comprised ~80% of the tumor and was composed of poorly-differentiated endometrioid adenocarcinoma. The remaining component consisted of mononucleated and syncytial giant cells containing rich eosinophilic cytoplasm and large pleomorphic nuclei with coarse chromatin. An immunohistochemical analysis revealed that these syncytial giant cells were positive for β-human chorionic gonadotropin (hCG). Therefore, a diagnosis of endometrioid adenocarcinoma with choriocarcinomatous differentiation was confirmed. The clinicopathological features of nine previously reported cases of this tumor were analyzed in addition to the present case. The majority of the patients were post-menopausal. Endometrial choriocarcinoma may be considered to have a highly aggressive clinical course, since nine of the 10 cases displayed metastases and four patients succumbed to the disease. The pathogenesis of the choriocarcinomatous component is not well understood. However, genetic studies have demonstrated that conventional carcinoma and choriocarcinomatous components share common genetic alterations. The choriocarcinomatous component represents aberrant differentiation of the conventional carcinoma, however, genetic analyses of endometrioid adenocarcinoma with choriocarcinomatous differentiation have not been performed.

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Choriocarcinoma of the sigmoid colon: report of a case

Cited by 17 publications

References 11 publications

Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome

Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome

Primary choriocarcinoma of the colon: a case report and review of the literature

Endometrioid adenocarcinoma with choriocarcinomatous differentiation: A case report and review of the literature

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