Rectal adenocarcinoma with choriocarcinomatous differentiation: Clinical and genetic aspects

Verbeek, Wieke H.M.; Schulten, Hans-Juergen; Sperling, M.; Tiesmeier, Jens; Stoop, Hans; Dinjens, Winand N.M.; Looijenga, Leendert H. J.; Wörmann, Bernhard; Füzesi, L.; Donhuijsen, K

doi:10.1016/j.humpath.2004.06.005

Cited by 39 publications

(48 citation statements)

References 14 publications

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“…Although one may question the hepatic tumor in these three cases that represent metastasis, the presence of a solitary tumor in the liver and multiple small nodules in the lung, adrenal glands, and peritoneum were more consistent with a primary hepatic choriocarcinoma with metastasis to the latter sites rather than the opposite. In addition, some carcinomas such as rectal adenocarcinoma [31], gastric adenocarcinoma [32], and lung adenocarcinoma [33] can have choriocarcinomatous differentiation. Theoretically, the choriocarcinomatous component can metastasize to the liver.…”

Section: Discussionmentioning

confidence: 99%

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Shi

Cao²,

Wei

et al. 2009

Virchows Arch

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Primary choriocarcinomas of the liver are rare. Previous reported cases were mostly in infants with only rare adult cases. Here, we presented five adult cases. The patients were all males, with an average age of 41.6 years (from 36 to 48 years). Clinical presentations included right upper abdominal pain or abdominal distension. All patients presented with a large hepatic mass on ultrasonography that measured 11 cm on average in the greatest diameter. Elevated serum human chorionic gonadotropin (HCG) levels were noted in all cases. At presentation, the tumor was confined to the liver in two patients and therefore surgically resected. The other three patients presented with extrahepatic metastases on imaging study and therefore only received chemotherapy. All five patients died from the tumor within 2 to 8 months. Autopsy was performed for all five cases. The autopsy confirmed that the choriocarcinoma was confined to the liver in two surgically resected cases. The other three patients had metastatic choriocarcinoma in the lung (two patients), peritoneum (one patient), adrenal glands (one patient), and brain (one patient). None of the patients had any evidence of a testicular tumor or scar after examination of the entirely submitted testes. No tumor was observed in central nervous system, mediastinum, or other organs other than described above. Grossly, the primary tumors were large, soft, hemorrhagic, and with foci of necrosis. Histologically, the tumors were composed of mononucleated trophoblastic cells with round nuclei, clear cytoplasm, and prominent nucleoli admixed with large, multinucleated syncytiotrophoblastic cells. Immunohistochemically, tumor cells were strongly positive for keratin, HCG, and focally positive for human placental lactogen. Ki-67 proliferation index was high (mean 75%) in the mononucleated trophoblastic cells. Our series is the largest one to document primary hepatic choriocarcinoma in adults. Although these tumors are rare, they behave in a very aggressive fashion.

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Section: Discussionmentioning

confidence: 99%

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Shi

Cao²,

Wei

et al. 2009

Virchows Arch

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“…Chromosomal anomalies have been described for choriocarcinomatous differentiation in many organ systems. In a rectal tumor case study, genetic changes of chromosomal regions 8p21-pter and 18q21-pter and gain of 5p and 20q were present in both the typical adenocarcinoma component and the choriocarcinomatous component (1). In a case study of urothelial carcinoma with choriocarcinomatous features, both tumor types showed losses of chromosomes 9 and 17p (2).…”

Section: Discussionmentioning

confidence: 91%

Anaplastic Large Cell Carcinoma with Choriocarcinomatous Features Metastatic to the Brain

Pepe¹,

Strobel²,

Graham³

2008

Journal of Histotechnology

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“…Nongestational, extragonadal choriocarcinoma is rare, but is occasionally found in the digestive tract, most frequently in the stomach. Primary choriocarcinoma of the colon is extremely rare, with only eight cases documented in the world literature (Table 1) [1][2][3][4][5][6][7][8]. These patients, including ours, consisted of three men and six women, with an average age of 51.6 years (range 29-74 years).…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma of the sigmoid colon: report of a case

2011

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Rectal adenocarcinoma with choriocarcinomatous differentiation: Clinical and genetic aspects

Cited by 39 publications

References 14 publications

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males

Anaplastic Large Cell Carcinoma with Choriocarcinomatous Features Metastatic to the Brain

Choriocarcinoma of the sigmoid colon: report of a case

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