Çocuklarda trombosit belirteçleri ve febril konvülziyon arasındaki ilişki

Abstract

AbstractÖz Purpose: Febrile seizures (FS) are the most common type of seizures in children.The aim of this study was to evaluate the relationship between platelet indices and FS in children. Materials and Methods:This prospective study included 40 children who presented with FS and 30 controls who presented with febrile illnesses without seizures. Complete blood counts, including platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) from both groups within 1 hour of FS and 1 month later were obtained. Results: We found that the MPV and PDW within 1 hour of seizure in children with complex FS group was higher than simple FS group while there was no significant difference in MPV and PDW between patients in the simple and complex FS groups at 1 month. The mean PC was not significantly different between simple and complex FS groups; but, we found that the mean PC in the complex FS group was slightly lower than simple FS group.There was a moderate significant positive correlation between MPV and PDW in children with FS while there was a moderate significant negative correlation between PC and MPV, PDW for FS . Conclusion: Our findings suggest that the increasing platelet turnover in complex FS group causes a slightly decrease in the PC, an significantly increase of MPV and PDW values indicating that these parameters may play an important role in predicting the severity of FS in children at diagnosis.

Inflammatory Biomarkers in Febrile Seizure: A Comprehensive Bibliometric, Review and Visualization Analysis

“…In addition, the last review (with meta-analysis) refers to cytokines: "Cytokine levels in febrile seizure patients: A systematic review and meta-analysis", written by Kwon [2]. Only a small number of publications have attempted to address the relationship between inflammatory biomarkers from blood (NLR, MPV, PLT, RDW) and febrile seizures [38][39][40][41][42][43]. Most of these publications are part of the green-yellow cluster (the north-west region on the network visualization map of publications, Figure 6).…”

“…It seems that NLR and MPV might synergistically determine the FS occurrence [2]. Moreover, NLR and MPV might differentiate simple versus complex febrile seizures [41,42].…”

“…Considering the network visualization of terms and network visualization of publications, we can highlight the fact that, in relation to inflammatory biomarkers in febrile seizures, there are two clusters of publications: the first one includes publications that address the relationship between cytokines/interleukins (expensive, not always available biomarkers) and febrile seizure, while the second one includes publications which address the relationship between biomarkers from blood (NLR, MPV, PLT, RDW-low-cost, available biomarkers) and febrile seizures. Among the most cited publications in the researched field are those referring to cytokines [31,32,54], and only a small number of publications have attempted to address the relationship between the aforementioned indices from blood and febrile seizures [41,42]. Moreover, there are studies in the literature that show IL's action on the liver, thus leading to increased C-reactive protein [56].…”

Mini Percutaneous Nephrolithotomy vs Standard Percutaneous Nephrolithotomy: A Perioperative Decision Support System for Surgical Success Comparison

“… 11 Hoerl and Kennard presented a detailed discussion of the unbiased estimation problem in regression. 12 The solution technique of Ridge regression is similar to the simple least squares method. In the Ridge regression method, the reversal is performed before calculating the coefficient estimates by adding a small and positive constant to the diagonal elements of the (X’X) matrix formed by the variables in standard form.…”