Inflammatory Biomarkers in Febrile Seizure: A Comprehensive Bibliometric, Review and Visualization Analysis

Maniu, Ionela; Costea, Raluca; Maniu, George; Neamţu, Bogdan

doi:10.3390/brainsci11081077

Cited by 21 publications

(16 citation statements)

References 60 publications

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“…We used the VOSviewer science visualization software package developed by Van Eck and Waltman at the Center for Science and Technology Studies of Leiden University [ 9 , 10 ]. The bibliometric approach using this tool was applied in studies from various areas of research [ 11 , 12 , 13 , 14 ]. We performed the following types of bibliographic techniques: citation analysis, co-word analysis, and co-citation analysis.…”

Section: Methodsmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Pediatric COVID-19 Population—A Bibliometric Analysis

Maniu

Totan

2022

JCM

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The literature on the COVID-19 landscape has rapidly expanded in the pandemic period. The current study undertakes a bibliometric analysis of research in the topic of the clinical and laboratory characteristics of pediatric COVID-19 cases. Our aim is to perform a comprehensive bibliometric review of current research trends and patterns of this research domain. Publications retrieved from the Web of Science Core Collection and VOSviewer were used for analysis and network visualization. We analyzed geographical distribution and temporal trends, collaboration and citation patterns of authors, institutions, and countries, and core research themes from co-occurrence of keywords and terms. The analysis showed that contributions in the research field were from 302 publications, 1104 institutions, 62 countries, and 172 journals. Many publications were authored by American and Chinese authors, and many were published in the Pediatric Infectious Disease Journal, Pediatric Pulmonology, and Frontiers in Pediatrics. The top cited and co-cited journals were the New England Journal of Medicine, Nature, JAMA, Lancet Infectious Diseases, and BMJ. The network visualization maps of keywords and terms offered a global overview of the clinical and laboratory characteristics of pediatric COVID-19 patients. The bibliometric profile of the researched domain, based on analyzing a large collection of publications/data, could (i) enrich the researchers and non-researchers understanding of the field existing patterns and trends, and (ii) be useful in clinical practice (diagnostic and management) and public health policy.

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Section: Methodsmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Pediatric COVID-19 Population—A Bibliometric Analysis

Maniu

Totan

2022

JCM

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“…In addition to IL-1β and HMGB1, in ammatory cytokines, including IL-6 and TNF-α, might also have facilitatory effect on the development of FS [43]. IL-1β can binds to IL-1 receptor type 1 (IL-1R1), a toll receptor family member, and induces the transcription of various genes that encode several downstream mediators of in ammation, including TNF-a and IL-6, via an NF-κB pathway [31,44].…”

Section: Discussionmentioning

confidence: 99%

Increased expression of NLRP3 associate with elevated levels of HMGB1 in children with febrile seizures: a case control study

She

et al. 2023

Preprint

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Background High mobility group box-1 (HMGB1) is an endogenous danger signal that mediates activation of the innate immune response including NLR pyrin domain containing 3 (NLRP3) inflammasome activation and pro-inflammatory cytokine release. Although HMGB1 and NLRP3 have been implicated in the pathophysiology of seizures, the correlation between HMGB1 and NLRP3 has not been determined in children with febrile seizures (FS). To explore the relationship between extra-cellular HMGB1 and NLRP3 in children with FS, we analyzed serum HMGB1, NLRP3, Capase-1, and pro-inflammatory cytokines of patients with FS. Methods Thirty FS children and thirty age-matched febrile controls were included in this study. Blood was obtained from the FS children within 1 hour of the time of the seizure; subsequently, the content of HMGB1, NLRP3, Capase-1, interleukin (IL)-1β, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) were determined by enzyme-linked immunosorbent assay. The Mann-Whitney U test was used to compare serum cytokine levels between FS patients and controls. The Spearman’s rank correlation coefficient was calculated to detect significant correlations between cytokine levels. Results Serum levels of HMGB1, NLRP3, Capase-1, IL-1β, IL-6, and TNF-α were significantly higher in FS patients than febrile controls (p < 0.05). Serum levels of HMGB1 were significantly correlated with levels of NLRP3 and Capase-1 (both, p < 0.05). Serum levels of Capase-1 were significantly correlated with levels of IL-1β (p < 0.05). Serum levels of IL-1β were significantly correlated with levels of IL-6 and TNF-α (p < 0.05). Conclusions HMGB1 are up-regulated in peripheral serum of FS patients, what may be responsible, at least in part, for the increased expression of NLRP3 and Caspase-1. Increased expression of Capase-1 was significantly associated with elevated serum levels of and IL-1β. Given that activated Caspase-1 directly regulates the expression of mature IL-1β and positively correlates with activation of NLRP3 inflammasome, our data suggest that increased levels of peripheral HMGB1 possibly mediate IL-1β secretion through the activation of NLRP3 inflammasome in children with FS. Thus, both HMGB1 and NLRP3 might be the potential target for preventing or limiting FS.

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“…is the main cause of children's febrile convulsion [9], In many studies, it has been found that the cerebrospinal uid IL-1 β The level and serum IL-6 level are related to the increased risk of FSs in children [22]. Therefore, after virus infection, immune cells represented by neutrophils and lymphocytes participate in the body's immune response to the virus, and the secretion of corresponding cytokines is unbalanced, that is, the key leukocyte factor, such as IL-1, that promotes the onset of febrile convulsion β HMGB1 IL-6 TNF-α And key cytokines that inhibit the onset of febrile convulsion, such as IL-10, IL-1 receptor antagonist (IL-1RA), INF-β Steady state imbalance between, causing FS [19,23]. IgA receptor Fc present on eosinophils α, when bacteria and viruses are adhered to by IgA in respiratory mucosa or skin mucosa, they can activate the immune response of eosinophils, thus inducing degranulation of eosinophils [24].…”

Section: Disscusionmentioning

confidence: 99%

The predictive value of eosinophils in children with febrile seizures

Xiao

2023

Preprint

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Objective To evaluate the predictive value of eosinophil count (EOS) in children with febrile seizures (FS). Methods a total of 92 children with FS who visited the Third Hospital of Changsha from May 2017 to May 2022 were selected as the observation group, another 61 children with only fever but no seizures (n-FS) who received respiratory infection from the outpatient clinic of our hospital were selected as the control group, and 35 children with health examination were selected as the healthy group. Differences between the groups in the levels of routine blood indicators, serum electrolyte levels, and blood gas analysis values were retrospectively analyzed to explore the predictive value of EOS and the neutrophil to eosinophil ratio (N/EOS) for FS in children using logistic regression and ROC curves. Results 1. Children in the FS had lower serum Na + levels (135.20 (3.24) mmol / L) than those in the n-FS group (136.90 (2.84) mmol / L) and the healthy group (138.00 (3.17) mmol / L) (P < 0.05); Serum K + levels (4.09 (0.59) mmol / L vs 4.23 (0.90) mmol / L), Cl − levels (100.40 (4.15) mmol / L vs 103.39 (2.77) mmol / L) and Ca2 + levels (2.22 (1.19) mmol / L vs 2.40 (0.25) mmol / L) in the FS group were also significantly lower than those in the healthy group (P < 0.05). 2. PH level in FS group (7.43 (0.05)) was higher than that in healthy group (7.38 (0.05)) (P < 0.05), while PCO2 value (95.10 (54.00) mmHg) was lower than that in healthy group (86.90 (43.90) mmHg) (P < 0.05). 3. EOS in the FS group was lower than that in the n-FS group, which was again lower than that in the healthy group (0.03 (0.10) vs 0.22 (0.30) vs 0.05 (0.18)) (P < 0.05). After treatment, children in the FS group had significantly higher EOS (0.06 (0.07) vs 0.17 (0.20)) (P < 0.05), which remained lower than those in the healthy and n-FS groups (0.17 (0.20) vs 0.25 (0.32) vs 0.23 (0.28)), (P < 0.05). 4. Multiple logistic regression suggested that blood K +, Ca2 +, EOS and PCO2 were significant for the diagnosis of FS, that is, for every 1 mmol / L increase in blood K +, the probability of FS decreased 2.38-fold (95% CI: 0.36–3.08), for every 1 mmol / L increase in blood Ca2 +, the probability of FS decreased 2.1-fold (95% CI: 1.75–13.29), for every 0.01 increase in EOS, the probability of FS decreased 0.68-fold (95% CI: 0.026–17.88), and for every 1 mmHg increase in PCO2, 1.1-fold (95% CI: 1.01–1.15) decrease in the probability of developing FS. 5. When the N/EOS value was 68.80, the area under the ROC curve was the largest at 0.70, the diagnostic sensitivity at this point was 76.3% and the specificity was 55.4%, and when this value was exceeded, the possibility of FS was considered. Conclusions Children with FS have significant hyponatremia, hypokalemia, and hypocalcemia, and EOS is also lower than in healthy children and n-FS children. After the children in FS group were treated, the EOS value was still lower than that in n-FS children, and the N / EOS value equal to 68.80 could be used clinically as an indicator to discriminate between them.

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Inflammatory Biomarkers in Febrile Seizure: A Comprehensive Bibliometric, Review and Visualization Analysis

Cited by 21 publications

References 60 publications

Clinical and Laboratory Characteristics of Pediatric COVID-19 Population—A Bibliometric Analysis

Clinical and Laboratory Characteristics of Pediatric COVID-19 Population—A Bibliometric Analysis

Increased expression of NLRP3 associate with elevated levels of HMGB1 in children with febrile seizures: a case control study

The predictive value of eosinophils in children with febrile seizures

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