Coated electrospun bioactive wound dressings: Mechanical properties and ability to control lesion microenvironment

Lima, Lonetá Lauro; Taketa, Thiago Bezerra; Beppu, Marisa Masumi; Sousa, Ilza Maria de Oliveira; Foglio, Mary Ann; Moraes, Ângela Maria

doi:10.1016/j.msec.2019.03.005

Cited by 50 publications

(27 citation statements)

References 62 publications

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“…For this purpose, the skin scaffold should have mechanical properties similar to those found in native tissue. In this regard, the values of the tensile strengths, the Young's modulus and the elongation-to-break are the most important parameters for assessing the suitability of the mechanical properties of the scaffold [74]. Although these values vary depending on the region of the native tissue, but according to the literature, the tensile strength between 5 and 40 MPa, the Young's modulus between 4.5 and 25 MPa, and the elongation-to-break between 35 and 120% seem to be appropriate for wound dressings [75,76].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

et al. 2021

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Skin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

et al. 2021

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“…The main properties used to construct an ideal functional scaffold for skin tissue engineering are summarized in Table 2. As discussed in the table, key properties that must be considered while designing an ideal wound healing scaffold, include biocompatibility, biodegradability, ECM simulated topographical and morphological properties, mechanical integrity, 67‐69 porosity, 70 hydrophilicity, 71 biological performance, multifunctional geometry, cellular signaling, and antibacterial activity 72 are all essential.…”

Section: Potential Of Mens For Wound Healing Applicationsmentioning

confidence: 99%

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Behere

Ingavle

2021

J Biomedical Materials Res

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The skin is one of the most essential tissues in the human body, interacting with the outside environment and shielding the body from diseases and excessive water loss. Hydrogels, decellularized porcine dermal matrix, and lyophilized polymer scaffolds have all been used in studies of skin wound repair, wound dressing, and skin tissue engineering, however, these materials cannot replicate the nanofibrous architecture of the skin's native extracellular matrix (ECM). Electrospun nanofibers are a fascinating new form of nanomaterials with tremendous potential across a broad spectrum of applications in the biomedical field, including wound dressings, wound healing scaffolds, regenerative medicine, bioengineering of skin tissue, and multifaceted drug delivery. This article reviews recent in vitro and in vivo developments in multifunctional electrospun nanofibers (MENs) for wound healing. This review begins with an introduction to the electrospinning process, its principle, and the processing parameters which have a significant impact on the nanofiber properties. It then discusses the various geometries and advantages of MEN scaffolds produced by different innovative electrospinning techniques for wound healing applications when used in combination with stem cells. This review also discusses some of the possible future nanofiber‐based models that could be used. Finally, we conclude with potential perspectives and conclusions in this area.

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“…The use of NPs, which are known to enhance mechanical durability, was expected to positively affect materials durability as well as acylated chitosan. The hypothesis was confirmed by the data given in Figure 6 showing tensile strength of the biomaterials corresponding to healthy skin [28,41]. The materials applicable in wound management should also be flexible.…”

Section: Mechanical Properties Studymentioning

confidence: 53%

“…Finally, Figure 8 shows the elastic modulus, which is comparable for all samples. Such results can be assigned to the presence of elastic aliphatic chains incorporated inside linear chitosan as well as doping with nanoparticles [27,28,41,42].…”

Section: Mechanical Properties Studymentioning

confidence: 99%

Hybrid Bilayer PLA/Chitosan Nanofibrous Scaffolds Doped with ZnO, Fe3O4, and Au Nanoparticles with Bioactive Properties for Skin Tissue Engineering

et al. 2020

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Burns affect almost half a million of Americans annually. In the case of full-thickness skin injuries, treatment requires a transplant. The development of bioactive materials that promote damaged tissue regeneration constitutes a great alternative to autografts. For this reason, special attention is focused on three-dimensional scaffolds that are non-toxic to skin cells and can mimic the extracellular matrix, which is mainly composed of nanofibrous proteins. Electrospinning, which enables the preparation of nanofibers, is a powerful tool in the field of biomaterials. In this work, novel hybrid poly (lactic acid)/chitosan biomaterials functionalized with three types of nanoparticles (NPs) were successfully developed. ZnO, Fe3O4, and Au NPs were investigated over their morphology by TEM method. The top layer was obtained from PLA nanofibers, while the bottom layer was prepared from acylated chitosan. The layers were studied over their morphology by the SEM method and their chemical structure by FT-IR. To verify their potential in burn wound treatment, the scaffolds’ susceptibility to biodegradation as well as moisture permeability were calculated. Also, biomaterials conductivity was determined in terms of electrostimulation. Finally, cytotoxicity tests were carried out by XTT assay and morphology analysis using both fibroblasts cell line and primary cells. The hybrid nanofibrous scaffolds displayed a great potential in tissue engineering.

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Coated electrospun bioactive wound dressings: Mechanical properties and ability to control lesion microenvironment

Cited by 50 publications

References 62 publications

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Hybrid Bilayer PLA/Chitosan Nanofibrous Scaffolds Doped with ZnO, Fe3O4, and Au Nanoparticles with Bioactive Properties for Skin Tissue Engineering

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