Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Nosrati, Hamed; Khouy, Reza Aramideh; Nosrati, Ali; Khodaei, Mohammad; Banitalebi-Dehkordi, Mehdi; Ashrafi-Dehkordi, Korosh; Sanami, Samira; Alizadeh, Zohreh

doi:10.1186/s12951-020-00755-7

Cited by 441 publications

(127 citation statements)

References 205 publications

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“…It then enabled better establishment of seedlings and its tolerance to salinity stress in rapeseed primed with PNC + TES than TES priming. Overall, in accordance with the findings in previous studies [ 49 , 55 , 57 ], our results suggested that improvement of α-amylase activity is one of the mechanisms underlying PNC nanopriming improved salt tolerance in Brassica napus .…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies showed that nanopriming [Zinc oxide (ZnO-NPs) nanoparticles, 50 ppm, 50 nm, 23 mV] enabled a positive correlation between improved α-amylase activity and seed germination and seedling vigor of lettuce plants [ 56 ]. Also, under cadmium stress, compared with control (0 mg/L ZnO NPs), rice plants primed with 25, 50 and 100 mg/L ZnO NPs nanoparticles (30 nm, zeta potential not reported) have significant increase on seedling α-amylase activities and seed germination rate and shoot fresh weight, thus showing improved tolerance to cadmium stress [ 57 ]. Researchers found that seeds with higher amount of total soluble sugars showed better performance in seedling buildup and also the tolerance to drought stress [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Nanoceria seed priming enhanced salt tolerance in rapeseed through modulating ROS homeostasis and α-amylase activities

Khan

et al. 2021

J Nanobiotechnol

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Background Salinity is a big threat to agriculture by limiting crop production. Nanopriming (seed priming with nanomaterials) is an emerged approach to improve plant stress tolerance; however, our knowledge about the underlying mechanisms is limited. Results Herein, we used cerium oxide nanoparticles (nanoceria) to prime rapeseeds and investigated the possible mechanisms behind nanoceria improved rapeseed salt tolerance. We synthesized and characterized polyacrylic acid coated nanoceria (PNC, 8.5 ± 0.2 nm, −43.3 ± 6.3 mV) and monitored its distribution in different tissues of the seed during the imbibition period (1, 3, 8 h priming). Our results showed that compared with the no nanoparticle control, PNC nanopriming improved germination rate (12%) and biomass (41%) in rapeseeds (Brassica napus) under salt stress (200 mM NaCl). During the priming hours, PNC were located mostly in the seed coat, nevertheless the intensity of PNC in cotyledon and radicle was increased alongside with the increase of priming hours. During the priming hours, the amount of the absorbed water (52%, 14%, 12% increase at 1, 3, 8 h priming, respectively) and the activities of α-amylase were significantly higher (175%, 309%, 295% increase at 1, 3, 8 h priming, respectively) in PNC treatment than the control. PNC primed rapeseeds showed significantly lower content of MDA, H2O2, and •O2− in both shoot and root than the control under salt stress. Also, under salt stress, PNC nanopriming enabled significantly higher K+ retention (29%) and significantly lower Na+ accumulation (18.5%) and Na+/K+ ratio (37%) than the control. Conclusions Our results suggested that besides the more absorbed water and higher α-amylase activities, PNC nanopriming improves salt tolerance in rapeseeds through alleviating oxidative damage and maintaining Na+/K+ ratio. It adds more knowledge regarding the mechanisms underlying nanopriming improved plant salt tolerance. Graphical abstract

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Nanoceria seed priming enhanced salt tolerance in rapeseed through modulating ROS homeostasis and α-amylase activities

Khan

et al. 2021

J Nanobiotechnol

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“…Advances in nanotechnology have greatly enhanced its potential usage in domestic, industrial, and biomedical applications [ 1 , 2 ]. Due to their unique physicochemical and biological properties, AgNPs are widely used, indicated by a significant increase in the number of products that contain AgNPs from about 30 in 2006 to more than 435 in 2015 [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The potential renal toxicity of silver nanoparticles after repeated oral exposure and its underlying mechanisms

et al. 2021

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Background Silver nanoparticles (AgNPs) can accumulate in various organs after oral exposure. The main objective of the current study is to evaluate the renal toxicity induced by AgNPs after repeated oral exposure and to determine the relevant molecular mechanisms. Methods In this study, 40 male Wistar rats were treated with solutions containing 30, 125, 300, and 700 mg/kg of AgNPs. After 28 days of exposure, histopathological changes were assessed using hematoxylin-eosin (H&E), Masson’s trichrome, and periodic acid-Schiff (PAS) staining. Apoptosis was quantified by TUNEL and immunohistochemistry of caspase-3, and the level of expression of the mRNAs of growth factors was determined using RT-PCR. Results Histopathologic examination revealed degenerative changes in the glomeruli, loss of tubular architecture, loss of brush border, and interrupted tubular basal laminae. These changes were more noticeable in groups treated with 30 and 125 mg/kg. The collagen intensity increased in the group treated with 30 mg/kg in both the cortex and the medulla. Apoptosis was much more evident in middle-dose groups (i.e., 125 and 300 mg/kg). The results of RT-PCR indicated that Bcl-2 and Bax mRNAs upregulated in the treated groups (p < 0.05). Moreover, the data related to EGF, TNF-α, and TGF-β1 revealed that AgNPs induced significant changes in gene expression in the groups treated with 30 and 700 mg/kg compared to the control group. Conclusion Our observations showed that AgNPs played a critical role in in vivo renal toxicity.

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“…Even systemically administered polyester nanoparticles loaded with curcumin, a potent anti-inflammatory extract, significantly reduced ocular inflammation in a lens-induced uveitis model [ 104 , 105 ]. Unfortunately, many of these aforementioned formulations of nanoparticles are in very preliminary stages of investigation and nanoparticle distribution and elimination in the eye are not well understood at this time [ 106 ].…”

Section: The Futurementioning

confidence: 99%

A Review of Ocular Drug Delivery Platforms and Drugs for Infectious and Noninfectious Uveitis: The Past, Present, and Future

Conrady

Yeh

2021

Pharmaceutics

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Uveitis refers to a broad group of inflammatory disorders of the eye that often require medical and surgical management to improve or stabilize vision and prevent vision-threatening pathological changes to the eye. Drug delivery to the eye to combat inflammation and subsequent complications from uveitic conditions is complex as there are multiple barriers to absorption limiting availability of the needed drug in the affected tissues. As such, there has been substantial interest in developing new drugs and drug delivery platforms to help reduce intraocular inflammation and its complications. In this review, we discuss the challenges of drug delivery, novel technologies recently approved for uveitis patient care and promising drug delivery platforms for uveitis and sequelae of ocular inflammation.

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Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Cited by 441 publications

References 205 publications

Nanoceria seed priming enhanced salt tolerance in rapeseed through modulating ROS homeostasis and α-amylase activities

Nanoceria seed priming enhanced salt tolerance in rapeseed through modulating ROS homeostasis and α-amylase activities

The potential renal toxicity of silver nanoparticles after repeated oral exposure and its underlying mechanisms

A Review of Ocular Drug Delivery Platforms and Drugs for Infectious and Noninfectious Uveitis: The Past, Present, and Future

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