This special issue of the Management Letters / Cuadernos de Gestión is dedicated, on one hand, to presenting those articles that are included as part of the special issue on innovation and, on the other hand, to disclose the top priorities on innovation research taking into account challenging topics we are witnessing in the business world that fuel research creativity. The first part of this editorial presents the four articles that make up this special issue on innovation. The second part of this editorial addresses the main topics of the shifting landscape innovation faces: business model innovation, artificial intelligence, Industry 4.0, Internet of things, innovation ecosystems and gamification.