Clinicopathological Study of Pigmented Skin Lesions

Suvernakar, S.V.; Harwani, Shweta R; A, Deshpande S.

doi:10.9790/0853-13557073

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…12 Newton-Bishop JA et al and Boniol M et al in their study also concluded that sun-sensitive phenotypes and reported sunburn were associated with an increased risk of melanoma. 13,14 The most common site involved in this study was head and neck (58.7%), followed by trunk ( 1,6,7 In a study performed by Valiukeviciene S et al, it was concluded that median densities of nevi was highest on the face which is similar to this study. 15 It was reported from Japan that 86% of skin melanomas were found in lower limbs and most of these were found in the sole which is comparable to this study where all the cases of malignant melanoma were seen in lower limbs.…”

Section: Discussionsupporting

confidence: 84%

“…19 Comparison of Clarks leveling of malignant melanoma of current study was done with those of studies performed by Suvernakar S et al, Konrad P et al, Hussein MR et al and Mukhopadhyay S et al (Table 3). 1,9,20,21 Of the 7 cases of melanoma diagnosed clinically only 5 were confirmed microscopically. The remaining 2 inconsistent case was of pigmented BCC.…”

Section: Discussionmentioning

confidence: 99%

“…6 In study done by Suvernakar S et al the melanocytic group comprised of benign melanocytic nevi, dysplastic nevi and malignant melanoma while seborrhoeic keratosis, pigmented actinic keratosis and pigmented basal cell carcinoma comprised the non-melanocytic lesions. 1 Leung K et al reported that non-melanocytic skin lesions commonly diagnosed as melanocytic tumors clinically included seborrheic keratosis, haematoma, skin tag, dermatofibroma, wart, basal cell carcinoma and inflammatory pigmentation. 10 Curley RK et al reported an overall sensitivity (diagnostic accuracy) of 50% in clinically evaluating pigmented lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Pigmented skin lesions (PSLs) include both melanocytic as well as nonmelanocytic lesions. 1 Disorders of pigmentation can result from migration abnormalities of melanocytes from neural crest to the skin during embryogenesis, impairment of melanosome transfer to keratinocytes and alteration in melanin synthesis. 2 Melanocytes are pigment-producing cells.…”

Section: Introductionmentioning

confidence: 99%

“…3 Pigmentation is not just a cosmetic deformity causing psychosocial upset but can also reflect underlying pathology as nevi and other benign pigmented lesions are important precursor of malignant melanoma. 1 Melanocytic proliferations are composed of one or more of three related cell types; melanocytes, nevus cells or melanoma cells, each of which may be in epidermis or dermis and occasionally in subcutis. Benign tumors of nevus cells are called melanocytic nevi, while malignant tumors are called malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

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Clinico-histopathological correlation of pigmented skin lesions: A hospital based study at BPKIHS

et al. 2019

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Background: Pigmented skin lesions refers to melanocytic as well as nonmelanocytic lesions. Pigmentation is not just a cosmetic deformity but can also reflect underlying benign pathology as nevi or malignant lesions as melanoma. With this study we intend to evaluate the spectrum of pigmented skin lesions and to correlate the clinical diagnosis with the histological diagnosis. Materials and Methods: This is a hospital based cross sectional descriptive study where clinicohistopathological evaluation of 46 cases of pigmented skin lesions were analyzed on paraffin embedded tissue sections for a duration of 1 year at the Department of Pathology, B. P. Koirala Institute of Health Sciences. Results: Out of the 46 cases evaluated there were 32 cases of melanocytic lesions comprising of benign melanocytic nevi (n=27), malignant melanoma (n=5) and 14 cases of nonmelanocytic lesions including basal cell carcinoma and seborrhoeic keratosis (5 cases each). Angiokeratoma (n=1), sebaceous hyperplasia (n=1), trichoepitheloma (n=1) and venous haemangioma (n=1). The age range was from 8-83 years with slight female predominance (52.2%) and the most common site involved was head and neck (58.7%). 76.1% of the patients belonged to the Terai region. Clinicohistopathological correlation showed positive correlation in 26 cases (56.5%) and negative correlation in 20 cases (43.5%). Conclusions: Pigmented skin lesions are common presenting problem, while majority are benign a small minority can be malignant. So, clinically pigmented skin lesions should be submitted for pathological examination in order not to miss a small percentage of malignant tumors and to differentiate melanocytic lesions from its nonmelanocytic mimickers.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinico-histopathological correlation of pigmented skin lesions: A hospital based study at BPKIHS

et al. 2019

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Pigmented Lesions of the Skin- A One-Year Study at Tertiary Care Centre

Kauser¹,

Pathuri²,

Jeshtadi³

et al. 2018

jemds

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BACKGROUND Melanocytic proliferations are commonly known as pigmented lesions and they are usually benign (90%), also called as Moles or Nevi. Malignant proliferations melanomas account for about 10%. Histopathological interpretation of these lesions is useful to differentiate non-neoplastic pigmented lesions from neoplastic pigmented lesions. Non-neoplastic pigmented lesions include seborrheic keratosis and pigmented actinic keratosis. Neoplastic pigmented lesions include pigmented basal cell carcinoma and malignant melanoma. Malignant transformations can be prevented by early removal of premalignant lesions. Aim-To study all the pigmented lesions, both melanocytic and non-melanocytic, with respect to their clinical features and histopathological findings. MATERIALS AND METHODSA retrospective case series study was conducted at Osmania General Hospital, Hyderabad, over a period of 1 year (Jan. 2017 -Dec. 2017) on all clinically pigmented lesions that were biopsied or excised. All lesions were analysed with respect to their important clinical and histological features. IHC was carried out using HMB-45 and S-100 where indicated. RESULTSA total of 31 cases were studied. The mean age for benign pigmented lesions was 25 years and male-to-female ratio of 1.2: 1. Mean age for melanomas was 60 years with female preponderance. Majority of the lesions were located on head and neck region. In this study, the commonest benign pigmented lesion was melanocytic nevi and pigmented basal cell carcinoma and melanoma among malignant lesions.

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A histo-pathological study with an emphasis on stratification of pigmented lesions of the skin

Anand¹,

Ilanthodi²,

N³

et al. 2020

IJPO

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Pigmented lesions can be close mimickers of melanoma and clinically challenging to diagnose. These can be melanocytic or non-melanocytic pigmented disorders. Pigmented lesions are close mimickers of melanoma and histopathology is a cornerstone for diagnosing these lesions. 1.To study the histomorphological patterns of pigmented lesions of the skin; 2. To categorise and differentiate pigmented lesions from melanoma based on histomorphology.A total of 70 histologically diagnosed cases of pigmented lesions of the skin were retrospectively studied from January 2018 to December 2019 in department of Pathology, of a Tertiary care center, Mangalore (India). Clinically suspicious skin lesions were taken up for the study. Sections from the skin punch biopsies and wide excision of the lesion were processed, stained with Hematoxylin and Eosin stain and studied for its histomorphological features.Out of the 70 cases studied, 22 cases were melanocytic lesions including 12 cases of Malignant melanoma (17.1%), Benign Naevi- 10 cases (14.2%) and 48 cases were non-melanocytic lesions including Lichen planus- 30 cases (42%), Seborrheic keratosis- 10 cases (14.3%), Basal cell carcinoma- 8 cases (11.4%).The pigmented lesions are categorised into melanocytic and non melanocytic lesions for a better understanding. Among the Melanocytic lesions, our study witnessed predominantly cutaneous melanoma. And in non melanocytic lesions lichen planus predominated.

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Clinicopathological Study of Pigmented Skin Lesions

Cited by 5 publications

References 8 publications

Clinico-histopathological correlation of pigmented skin lesions: A hospital based study at BPKIHS

Clinico-histopathological correlation of pigmented skin lesions: A hospital based study at BPKIHS

Pigmented Lesions of the Skin- A One-Year Study at Tertiary Care Centre

A histo-pathological study with an emphasis on stratification of pigmented lesions of the skin

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