Clinicopathological Analysis of Polypoid Lesions of Cervix

Abstract

BACKGROUND:Polypoidal lesions of cervix show various morphological spectrum ranging from inflammatory to neoplastic lesions. In addition to endocervical polyps there are many other polypoidal lesions that appear clinically like endocervical polyps. They are often secondarily inflamed or ulcerated and contain foci of squamous metaplasia. AIM: To study clinicopathological aspects of cervical polypoid lesions. OBJECTIVES: To study the histopathological features of cervical polypoid lesions and to assess their associated clinical features and age wise incidence. MATERIALS AND METHODS: All specimens mentioned as cervical polyp based on the clinical appearance were included in the study. All such polyps from cervix/cervical os were removed and sent for histopathological examination to our department. In some cases we got complete polyp and in some fragments of polyp. All these Specimens obtained with relevant clinical data were formalin fixed and processed with standard procedures. Sections were stained with routine Haematoxylin and eosin stain. We studied various histopathological features and analysed for associated clinical features. RESULTS: During the study period we got 22 cases of cervical polyps. They are common between 20-50yrs. Common associated clinical features were history of bleeding per vagina or white discharge per vagina. The most common type of polypoidal lesion in this study was classical Endocervical polyp(13). Most of them showed cystic changes and nearly half of endocervical polyps showed squamous metaplasia . Other polypoidal lesions we encountered in this study were Leiomyoma (3), Adenomatous polyp (1), Adenoleiomyoma (1) and Nabothian cyst (2). CONCLUSION: It appears that the entities such as Polypoidal endocervicitis , Endocervical polyp and Fibroepithelial polyp belong to spectrum of a single entity in the pathogenesis process with Polypoidal endocervicitis as initial lesion, Endocervical polyp as intermediate lesion and Fibroepithelial polyp as a last stage in the pathogenesis process of same entity. They need to be removed in symptomatic cases and in cases where there is high probability of harboring malignant foci. Regular followup can be done in other cases. Further large studies needs to be conducted to evaluate various aspects of endocervical polyps.

A Histopathological Study of Neoplastic Lesions of Uterine Cervix of Peri and Postmenopausal Women

“…This finding correlates with a study conducted by Gupta N et al 4 Amongst the benign neoplasm, endocervical polyp was the commonest diagnosis seen in 28 (73.7%) out of 38 cases of benign lesions or 3.48% of total cervical lesions and they were seen mostly in the 41-50 years age group. Common associated clinical features were history of bleeding per vagina or white discharge per vagina that correlate with the findings by Sidhalingreddy et al 5 Leiomyomatous polyps constituted 10 (26.3%) out of 38 cases of benign lesions or 1.2% of total cervical lesions and majority of them were seen in the 41-50 years age group and most of them were found in cases with clinical diagnosis of fibroid uterus that correlated with the study of Dr. Vaishali et al 6 Cervical Intraepithelial Neoplasia Out of 803 total cervical specimens, total 67 cases of cervical intraepithelial neoplasia (8.3%) were found in this study. From various studies, it is seen that the prevalence of CIN in present study is almost equal with the study conducted by Sinha P et al 3 and Gupta N et al 4 Most cases of severe dysplasia were found in the age group of 41-50 and 51-60 years.…”

Histopathological Study of Lesions of Uterine Cervix

“…It appears that the entity fibroepithelial polyp belong to spectrum of a single entity in the pathogenesis process with polypoidal endocervicitis as initial lesion, endocervical polyp as intermediate lesion and fibroepithelial polyp as a last stage in the pathogenesis process of same entity. These observations correlated well with studies done by Sidhalingreddy et al 10 and Poste et al 11…”

A 10-Year Histopathologic Audit of Uterine Cervical Biopsies in Warri, Nigeria

“…These fibroepithelial proliferations were observed to occur most commonly in the 4 th and 5 th decades of life as had been described earlier [47,48,49,50]. The current study has shown that inflammatory squamous (ec-tocervical) polyps were the most abundant variety in contrast to that described by Sidhalingreddy et al, 2013, where most polyps were endocervical in origin [51]. Well et al explained that these lesions might actually be precursors to condylomas, benign tumours induced by exposure to HPV [52].…”