A B S T R A C TBackground: Benign breast diseases (BBDs) constitute a source of morbidity and mortality among women globally. Most of these lesions are common in women of reproductive age and are associated with hormonal infl uences. However, studies have reported an increasing incidence of these lesions in children and adolescents. Aims: The aim was to highlight the spectrum and histological patterns of BBDs among women in Delta State and other Southern states of Nigeria as seen at central hospital, Warri. Materials and Methods:This study was a 7-year retrospective analysis of all histologically diagnosed breast diseases in women. Request forms were scrutinized for clinical bio-data, diagnosis. Hematoxylin and eosin stained-slides of breast biopsies carried out at the central hospital, Warri were archived and studied. Results: A total of 905 breast lesions were received during this 7 years period in the Pathology Department. Of these, 644 cases accounting for (71.2%) were benign lesions, while 261 cases (28.8%) were malignant giving a ratio of 2.5:1. A total of 638 cases occurred in female while only 6 cases occurred in males. The mean age was 31.2 ± 8.4 years, and the peak age incidence was 20-29 years constituting 49.8% cases of BBDs. Fibroadenoma was the most common BBD accounting for 302 cases (46.9%). Fibrocystic disease was the second majority and constituted 126 cases (19.6%). Conclusion: Fibroadenoma constituted the most common histopathological patterns of BBDs in children and adolescents in our environment.

ODOKUMA, E. I.; EGHWORO , O.; AVWIORO, G. & AGBEDIA, U. Tongue rolling and tongue folding traits in an African population. Int. J. Morphol., 26(3):533-535, 2008.SUMMARY: Genetic variations that occur in humans are usually as a result of a plethora of factors which are of enormous value from physical anthropological window especially in studying population variation and human diversity. This study was conducted amongst unrelated volunteer students of Delta State University, Nigeria who were all of Urhobo tribe (71 males) and (72) females aged between 18 years and over to determine their ability to roll or fold the tongues. The frequency of folders (120) and rollers (87) were more common than non-folders (23) and non-rollers (56).The incidence of tongue rolling was higher in females than in their male counterparts. These differences did not however show any statistical significance, p > 0.01. The frequency of R-F was observed to be highest in both males and females (38 and 43) respectively. 22 males and 17 females were observed to be capable of fold but unable to roll their tongue. None rollers and none folders were 9 males and 7 females respectively while rollers and none-folders were the least with frequencies of 2 males and 3 females respectively.ODOKUMA, E. I.; EGHWORO , O.; AVWIORO, G. & AGBEDIA, U. Tongue rolling and tongue folding traits in an African population. Int. J. Morphol., 26(3):533-535, 2008.

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Nicotine has been defined as a potent parasympathomimetic alkaloid that accumulates in the roots and leaves of Nightshade family of plants Aim: This study was aimed at evaluating the effects of orally ingested nicotine in the histology of hippocampus, substantia nigra and cerebellum.Materials and Methods: Twenty four adult male Wistar rats (100g – 200g) were randomly divided into 4 groups (group 1 – group 4). Group 1 served as the control group, while groups 2 - 4 were the treated groups. Nicotine was diluted in water and 1ml of the different dosage (2mg/kg/day, 4mg/kg/day and 6mg/kg/day) were administered to the treated groups respectively with the aid of orogastric cannula for 42 days. Animals were euthanized by cervical dislocation at the end of 7, 21 and 42 days so as to demonstrate the dose and time dependant effect of this agent. Brain tissues were harvested, processed and stained using Haematoxylin and eosin according to standard histological techniques. Stained tissue images were captured using digital micrometer eyepiece and cell count was determined using stereological technique.Statistical analysis: Data obtained were subjected to statistical analysis with the use of statistical package for social sciences (SPSS version 20). Significant differences were obtained using One Way Analysis of Variance with a probability of  0.05 (95% confidence limit) and Tukeys post hoc  test was further used to determine the mean significant differences between specific groups.Results: Histological findings showed mild, moderate and severe hyperplasia in a dose and time dependant manner. However, observations from quantitative analysisalso revealed a dose and time dependant significant increase in neuronal cell count and cell diameter of the hippocampus, Substantia nigra and cerebellum.Conclusion: This study has demonstrated that oral exposure of Nicotine in rats display proliferative adaptive changes on the hippocampus, substantia nigra and cerebellum in a dose/time dependent manner.

Pollutions due to anthropogenic sources have made some animals possible carriers of certain toxic substances which could have detrimental effects on humans. In this study, the concentrations of lead (Pb), cadmium (Cd), mercury (Hg) and chromium (Cr) in the hair, kidney and liver of cattle and goats in the oil producing areas (OPA) and none oil producing areas (NOPA) of Ondo state, Nigeria, were evaluated. Hair, kidney and liver samples were collected from four purposely selected Local Government Areas in Ondo state in replicates, dried and digested using a 1:3 mixture of concentrated perchloric acid (HClO4) and trioxonitrate (v) acid (HNO3). Data collected were analyzed completely randomized design (CRD) and significant means were separated using Duncan multiple range test. Lead concentration (mg/kg) were not significantly different in the organs of cattle (mean = 0.076) and goats (mean = 0.043) in the OPA but varied significantly in the NOPA with highest values in the hair of cattle (0.081) and kidney of goat (0.056). Oil exploration effect was only significant in Pb deposition in the kidney. Cadmium values (mg/kg) ranged from 0.009 to 0.031 in cattle and from 0.010 to 0.020 in goats with no significant variation. However, oil exploration showed significant effect in the Cd deposition in the kidney of cattle. Mean values of mercury concentration (mg/kg) in cattle were between 0.022 to 0.054 and 0.029 to 0.039 in goats from the OPA. In the NOPA, Hg concentration did not vary significantly in the organs of cattle but showed significant variation in the organs of goats with values ranging from 0.016 – 0.046 mg/kg. Chromium concentration (mg/kg) varied between 0.004 to 0.020 in cattle and 0.005 to 0.025 in goats with no significant variation. Conclusively, all the heavy metal concentrations obtained from analysis of the hair, kidney and liver from both the oil producing and the non – oil producing areas were below permissible limits reported by some regulatory bodies.