A Histopathological Study of Neoplastic Lesions of Uterine Cervix of Peri and Postmenopausal Women

Abstract

BACKGROUNDNeoplastic lesions of uterine cervix is one of the most common malignant neoplasms in women. The tremendous success in giving a confirmed diagnosis of the disease by doing histopathological examination is of prime importance in giving the most appropriate treatment and to understand the prognosis.The aim of the study is to study the incidence and age-wise distribution of the neoplastic lesions of the uterine cervix in peri and postmenopausal women by doing histopathological examination of neoplastic lesions and by doing correlation of clinical findings with histopathological examination. MATERIALS AND METHODSThe study included 803 cases of total cervical specimens, out of which 180 cases of neoplastic cervical lesions were found, out of which 150 cases were found in the peri and postmenopausal age groups, i.e. above 40 years of age. The study was done in Gauhati Medical College and Hospital, Guwahati, from the period 1 st June, 2013, to 1 st June, 2014. The specimens that were included in the study were punch biopsies, hysterectomies and polypectomies and cervical specimens were studied by doing histopathological examinations. RESULTSOut of the 150 cases of neoplastic lesions in the peri and postmenopausal women, the most common neoplastic lesion was cervical intraepithelial neoplasia, i.e. CIN (8.3%) of the cervix, followed by malignant (5.6%) and benign (4.7%) lesions of the cervix in this study group of patients. CONCLUSIONHistopathological examination of the cervix is an effective method of giving a confirmed diagnosis of all the noncancerous, precancerous and cancerous lesions of uterine cervix, which helps in giving the most appropriate treatment and also helps in understanding the prognosis.

A Study of Cervical Lesions in Correlation With Human Papillomavirus Analysis by Immunohistochemical Assay

“…In our study, moderately differentiated squamous cell carcinomas account for 86.66% of the cases, followed by well differentiated squamous cell carcinomas and poorly differentiated squamous cell carcinomas, which account for 6.66% each. Squamous cell carcinoma was classified into well, moderate, and poorly differentiated carcinomas at the time of initial diagnosis in the Kakati and Bhuyan [21] study. Out of 40 squamous cell carcinoma cases, 22 (55%) were moderately differentiated, 12 (30%) were well-differentiated, and 6 (15%) were poorly differentiated.…”