Clinical Study of Obestatin Hormone and its Relation to Diabetes Mellitus

Allwsh, Thikra A.; Mohammad, Jehan A.

doi:10.33899/rjs.2013.77818

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…The results of the current study are in a decent agreement with those obtained by other investigators [15,16,17], in which they as well noticed low concentrations of obestatin in diabetic patients. The cause of this decrease in type II diabetic patients might be related to obestatin role in appetite regulation [16] or the increase of body mass index and insulin insensitivity [18].…”

Section: The Values Are Expressed As Mean ± Sesupporting

confidence: 93%

Alterations of Obestatin, Cardiac Markers and Lipid Profile Levels in Type 2 Diabetes Mellitus

Balaky¹,

Kakey

2021

eijs

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The current investigation aimed to test the alterations of the levels of obestatin hormone, lipid profile and cardiac function markers in relation to hyperglycemia in patients with non-insulin diabetes mellitus. The study included 118 diabetic subjects (56 males, 62 females) and 60 healthy non-diabetic subjects (30 males, 30 females). Diabetic and healthy subjects were age-matched. Serum levels of obestatin, lipid profile markers including total cholesterol (STC), triglycerides (STG), low and high density lipoproteins (LDL-C and HDL-C), as well as cardiac function markers including, creatine kinase and lactate dehydrogenase enzymes were determined in all subjects. The findings revealed a remarkable decrease in the level of serum obestatin in both diabetic males and females with both age ranges (40-59 and 60-80 years). On the other hand, the results showed that serum STC, LDL-C, and STG levels were statistically significantly elevated, while that for HDL-C was significantly decreased in diabetic males and females with both age ranges. Concerning the cardiac markers, the results found out that the levels of CK-MB and LDH were significantly increased in type 2 diabetic males and females with both age ranges. The results suggested that a low concentration of obestatin is a significant risk factor for type 2 DM, with a key role for this hormone in the pathogenesis. Accordingly, altered levels of obestatin could be used as an important indicator for type 2 DM. The current study also suggests a direct relationship between lipid profiles, except for HDL, the decreased obestatin level, the increased cardiac function markers, and hyperglycemic status in type 2 DM.

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Section: The Values Are Expressed As Mean ± Sesupporting

confidence: 93%

Alterations of Obestatin, Cardiac Markers and Lipid Profile Levels in Type 2 Diabetes Mellitus

Balaky¹,

Kakey

2021

eijs

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“…As shown in table (1) adiponectin concentration showed a significant decrease in patients comparing to control group and that might be due to high cholesterol diet or due to increase insulin which cause insulin resistance, then decreased adiponectin concentration [33,34] or may be due to increased oxidative stress and oxygen species which decrease adiponectin gene ADIPOQ expression [35].…”

Section: Concentration Of Adiponectin In Hyperlipidemia Patients Comparing To Control Groupmentioning

confidence: 97%

The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients

2021

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This research included study the relation between FGF21 and insulin resistance in hyperlipidaemia. The results demonstrated that the normal mean of FGF21 in serum control group was (69.4±2.9 pg/ml) and there was a significant increasing in FGF21 concentration in patients (108.05±4.03 pg/ml ) compared with control group, also the results showed a significant increase in the concentration of fasting glucose, insulin, homeostasis model for insulin resistance (HOMA-IR), Total cholesterol, Triglycerides, low density lipoprotein for cholesterol (LDL-C) and very low density lipoprotein for cholesterol (VLDL-C) and malondialdehyde (MDA), while a significantly decrease had been shown in concentration of high density lipoprotein for cholesterol (HDL-C), adiponectin and arylestase activity in hyperlipidemia patients compared with control group. Correlation coefficients of FGF21 hormone with these clinical parameters showed a positively significant correlation with Glucose, insulin, HOMA-IR, Total cholesterol, Triglycerides, LDL-C, VLDL-C and MDA concentration, while FGF21 elucidated a significant negative correlation with HDL-C, arylesterase activity and adiponectin concentration. The conclusion of this study was that FGF21 concentration correlated significantly in hyperlipidemia with insulin resistance, and FGF21 high concentration can be represented as a biomarker in hyperlipidemia.

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The Effect of Isolated Obestatin Hormone from Plasma on some Biochemical Parameters in Normal and Diabetic Rats

Allwsh¹,

Mohammad²

2014

RJS

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The study included an attempt to isolate and purify obestatin from healthy human plasma using different biochemical techniques. Two proteinous peaks had been isolated by gel filtration chromatography (Sephadex G-50) from the precipitate produced by precipitation using cold acetone. It was found that the second peak (peak B) only had an obestatin. Two proteinous components had also been isolated by the same technique using Sephadex G-25 from the peak B. It was found that the second peak (peak D) had a high concentration of obestatin. Furthermore, the purity of the isolated obestatin (peak D) had been identified by the reversed phase high performance liquid chromatography and by SDS-polyacrylamide gel electrophoresis technique. The results obtained from the RP-HPLC showed that there was a good identity in retention time between the standard and the isolated obestatin (peak D). The approximate molecular weight of partially purified obestatin was (2573 ± 100 Da) and (2660 Da) using gel filtration chromatography by Sephadex G-25 and (SDS-PAGE) technique respectively. The effect of the isolated obestatin (peak D) on some biochemical parameters in normal and alloxan induced diabetic male rats had been studied. After one week of treatment, the results showed that the obestatin at the dose (1 µmol / kg of body weight / d) caused a significant decrease in the levels of glucose, total lipids, total cholesterol, triglycerides, LDL-C, VLDL-C and MDA, in a addition to a significant increase in the levels of HDL-C in normal and alloxan induced diabetic rats and GSH in alloxan induced diabetic rats. It was concluded that the isolated obestatin from plasma had a an important role in metabolism of glucose and lipid profile in normal and alloxan induced diabetic rats.

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Clinical Study of Obestatin Hormone and its Relation to Diabetes Mellitus

Cited by 4 publications

References 41 publications

Alterations of Obestatin, Cardiac Markers and Lipid Profile Levels in Type 2 Diabetes Mellitus

Alterations of Obestatin, Cardiac Markers and Lipid Profile Levels in Type 2 Diabetes Mellitus

The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients

The Effect of Isolated Obestatin Hormone from Plasma on some Biochemical Parameters in Normal and Diabetic Rats

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