The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients

Jasim, Rana F.; Mohammad, Safaa S.; Allwsh, Thikra A.

doi:10.21608/ejchem.2021.80062.3947

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…These findings indicate a correlation between asprosin levels and obesity since asprosin levels rise as body mass index (BMI) rises. [19][20] The results explain (Campbell and Drucker,) HypoVitaminosis D and the metabolic syndrome (MetS), that show a disorder marked by the presence of central obesity, arterial hypertension, and altered lipid and glucose metabolism, may be related, according to a number of studies. [34][35] Lower 25(OH) D concentrations were independently linked to a higher risk of MetS, according to many studies.…”

Section: The Concentration Of Asprosin Hormone and Vitamin D In The C...mentioning

confidence: 97%

Study interplay between Asprosin with Vitamin D in metabolic syndrome

Mohammed

Allwsh

2022

J. Contemp. Med. Sci.

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Objective: The study aims to in investigating the role of the asprosin hormone and its relationship with vitamin D in patients with metabolic syndrome and clinical parameters. Methods: The study included measurement asprosin hormone, vitamin D, and some biochemical variable levels in metabolic syndrome patients with age matching to the control group (35 - 65 years). The study includes (95) samples of metabolic syndrome patients [49female, 46 males] who were attending the abdominal consultation unit at the Ibn Sina Teaching Hospital in Mosul, Iraq . MetS were diagnosed in compliance with the criteria of the NCEP (ATP III) and AHA/ NHLB . Samples were collected during the period from January 2021 to December 2021. Also, the study was carried out on 76 samples of apparently healthy (40 female, 36 male) as a control group. Results: The findings revealed a significant increase in the concertation of the asprosin hormone in metabolic syndrome patients compared to the control group. Also, it has been found that was a significant increase in the concertation of fasting glucose, insulin, homeostasis model for insulin resistance (HOMA-IR), Triglycerides , low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol , total cholesterol and urea. In addition to a decline in high-density lipoprotein cholesterol , non-high-density lipoprotein cholesterol (Non-HDL), (HOMA-B ), vitamin D and Calcium among metabolic syndrome patients. there is also a significant inverse correlation between asprosin hormone with the Vitamin D. Conclusion: The study concluded that the hormone asprosin is a good indicator that reflects the status of metabolic syndrome patients and vitamin D appeared to be associated with MetS, as well as the Insulin resistance (IR) and lipid profile.

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Section: The Concentration Of Asprosin Hormone and Vitamin D In The C...mentioning

confidence: 97%

Study interplay between Asprosin with Vitamin D in metabolic syndrome

Mohammed

Allwsh

2022

J. Contemp. Med. Sci.

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“…23 • Arylesterase activity: was measured by using enzymatic hydrolysis of phenyl acetate to produce phenol and acetic acid. 24,25 • Malondialdehyde (MDA): was measured by using thiobarbituric acid was used to assess malondialdehyde. 26 • Peroxidase activity: was measured by using enzymatic oxidation of hydrogen peroxide by peroxidase.…”

Section: • Total Antioxidant Capacity (T-aoc): Was Measured Bymentioning

confidence: 99%

Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients

Mahmood

Allwsh

2022

J. Contemp. Med. Sci.

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Objective: This study aimed to estimate the levels of HER2, PD-L1 and oxidative stress in newly diagnosed breast cancer patients. Also, to estimate the probability of using HER2 and PD-L1 as a predictive marker on the occurrence of breast cancer in addition to study the effect of menopausal status at the level of HER2, PD-L1, oxidative stress and breast cancer risk factor. Methods: This study included 125 newly diagnosed breast cancer patients (53 premenopausal and 72 postmenopausal) from Oncology and Nuclear Medicine Hospital in Mosul, Iraq, and 100 apparently healthy women as a control group (44 premenopausal and 56 postmenopausal), during the period from Jan. 2021 to Jun. 2021. The ages of patients and control are matched, and it is ranged from 30-60 years. In this study we estimate the level of Human Epidermal Growth Factor Receptor 2 (HER2), Programmed Death -Ligand 1(PD-L1), total antioxidant capacity (T-AOC), arylesterase activity, uric acid level, malondialdehyde (MDA) level, peroxidase activity, lactoperoxidase activity and iron level at breast cancer patients and control. Results: The results show that there is a significant elevation in the level of HER2, PD-L1, malondialdehyde, peroxidase, lactoperoxidase and iron, and a significant decrease in the level of T-AOC, arylesterase and uric acid in the serum of breast cancer patients (pre and postmenopausal) compared with the control group (pre and postmenopausal). Also, increase the level of HER2 and oxidative stress at postmenopausal status for the control and patient groups. while PD-L1 level does not affect by menopausal status for both control and patient groups. Conclusion: The level of HER2, PD-L1, and oxidative stress was significantly increased in newly diagnosed breast cancer patients compared with the control group at the same menopausal status. Increase breast cancer risk factor at the postmenopausal status.

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Indoleamine 2,3-dioxygenase level and oxidative stress parameters in the serum of patients with chronic renal failure

Saeed,

Jasim

2023

Ukr.Biochem.J.

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Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme belonging to the kynurenine pathway. IDO activity has been suggested as a biomarker for diagnosis of chronic kidney disease. The aim of the study was to estimate the level of IDO, urea, creatinine, uric acid, phosphate, calcium, albumin, MDA, GSH, and activity of peroxidase, catalase, arylesterase in the serum of chronic renal failure (CRF) patients treated with dialysis compared to the healthy control group. The results showed a significant increment in IDO level in patients compared with the control. Linear regression analysis using the Pearson correlation coefficient showed that increased IDO level correlates positively with urea, creatinine, uric acid, phosphate, MDA level and peroxidase activity whereas negatively with albumin, calcium, glutathione level, catalase activity and glomerular filtration rate. We concluded that IDO level might be a possible marker of oxidative stress and inflammation in patients with CRF. Keywords: 3-dioxygenase, biochemical parameters, correlation analysis, indoleamine 2, renal failure, serum

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The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients

Cited by 4 publications

References 34 publications

Study interplay between Asprosin with Vitamin D in metabolic syndrome

Study interplay between Asprosin with Vitamin D in metabolic syndrome

Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients

Indoleamine 2,3-dioxygenase level and oxidative stress parameters in the serum of patients with chronic renal failure

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