Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy

Abstract

It would be important to predict type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). This study was aimed at evaluating the predicting significance of hemostatic parameters for T2DM and DN. Plasma coagulation and hematologic parameters before treatment were measured in 297 T2DM patients. The risk factors and their predicting power were evaluated. T2DM patients without complications exhibited significantly different activated partial thromboplastin time (aPTT), platelet (PLT), and D-dimer (D-D) levels compared with controls (P < 0.01). Fibrinogen (FIB), PLT, and D-D increased in DN patients compared with those without complications (P < 0.001). Both aPTT and PLT were the independent risk factors for T2DM (OR: 1.320 and 1.211, P < 0.01, resp.), and FIB and PLT were the independent risk factors for DN (OR: 1.611 and 1.194, P < 0.01, resp.). The area under ROC curve (AUC) of aPTT and PLT was 0.592 and 0.647, respectively, with low sensitivity in predicting T2DM. AUC of FIB was 0.874 with high sensitivity (85%) and specificity (76%) for DN, and that of PLT was 0.564, with sensitivity (60%) and specificity (89%) based on the cutoff values of 3.15 g/L and 245 × 109/L, respectively. This study suggests that hemostatic parameters have a low predicting value for T2DM, whereas fibrinogen is a powerful predictor for DN.

White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

“…Also, Elevated WBC count even within the normal range has been reportedly associated with micro and macrovascular complications. 48,49 Evidence from epidemiological studies suggests an association between the WBC count, a non-specific marker of inflammation, and diabetes risk. 50 A significant negative correlation was found between neutro- production of cytokines may lead to inappropriate activation and tissue damage and even increase vulnerability to invasive microorganisms.…”

Clinical and predictive significance of Plasma Fibrinogen Concentrations combined Monocyte-lymphocyte ratio in patients with Diabetic Retinopathy

“…Furthermore, plasma fibrinogen is important in the regulation of inflammatory response 15 , and plasma fibrinogen levels are associated with increased inflammation 10 . Our previous studies have revealed that plasma fibrinogen is a powerful predictor for diabetic nephropathy in patients with T2D 16 , and combined plasma fibrinogen concentrations and MLR (FC-MLR) can be used as a powerful prognostic index of ovarian cancer 18 . Therefore, fibrinogen may play a combined role with MLR in inflammatory diseases.…”

Platelet distribution width, platelet count, and plateletcrit in diabetic retinopathy

“…Studies have shown that some changes of hemorheology would occurred in DM, especially PLT parameters, which leads to pathological changes of blood vessels. [10,11,34,35] As 2 important parameters of platelet, PDW and PLT attracted researchers’ attention and different opinions about whether they differ between patients and healthy controls were proposed. Thus, we systematically reviewed and summarized through a meta-analysis to explore the relationship between platelet parameters and DR, for identifying biomarkers for early detection of diabetic complications.…”

“…[10] And PLT also was reported to be an independent risk factor for type 2 diabetic mellitus (T2DM) and diabetic nephropathy. [11]…”