White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

Adane, Tiruneh; Asrie, Fikir; Getaneh, Zegeye; Getawa, Solomon

doi:10.1002/jcla.23808

Cited by 18 publications

(20 citation statements)

References 42 publications

(35 reference statements)

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“…On the other hand, the mean of Hct, MCV, MCH, and RDW-SD was statistically significantly low in T2DM patients as compared to the healthy control group. This result was similar to the findings reported in India, Brazil, Saudi Arabia, Sudan, and Ethiopia in which MCH, MCHC, hematocrit, and RDW-SD were significantly reduced in diabetes compared to healthy controls [ 9 , 27 – 30 ]. In diabetic patients, multiple risk factors such as hyperglycemia, hyperosmolarity, oxidative stress, inflammation, and lipid metabolic disorder may affect RBCs metabolism as they may increase aggregation, reduce cell deformability, and reduce membrane fluidity.…”

Section: Discussionsupporting

confidence: 91%

Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study

Ebrahim

Fiseha

Ebrahim³

et al. 2022

PLoS ONE

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Background Diabetes mellitus (DM) is a chronic condition associated with raised levels of blood glucose due to the body cannot produce any or enough insulin hormone or cannot be effectively utilized the produced insulin by the body. Patients with poorly controlled diabetes show a significant alteration in various parameters including metabolic, cellular, immunological, and hematological disturbances that leads to vascular complications. Thus, the main aim of this study is to compare hematological parameters between type 2 diabetes mellitus (T2DM) patients and healthy controls. Methods A comparative cross-sectional study was conducted in Dessie comprehensive specialized hospital from January to June 2021. A total of 240 study participants consisting of 120 T2DM patients and 120 healthy controls were recruited using a systematic random sampling technique. Hematological parameters were determined using the DIRUI BF6500 automated hematology analyzer. Independent T-test was used to compare the mean of hematological parameters between T2DM patients and healthy controls. Pearson correlation test was used to determine the correlation between FBG, BMI, SBP, DBP, and hematological parameters in T2DM patients. Multivariate logistic regression was used to assess the association between socio-demographic and clinical variables with anemia. The result was expressed in mean and standard deviation and presented in texts and tables. P-value < 0.05 was considered to be statistically significant. Results The mean and standard deviation of monocyte count, basophil count, monocyte %, basophil %, RBC count, hematocrit, MCV, MCH, RDW-SD, MPV, PDW, PLC-R, and plateletcrit showed a significant difference between T2DM patients and healthy control group. Pearson correlation coefficient showed that the total WBC count, neutrophil count, monocyte count, basophil count, RDW-CV, PDW, MPV, PLC-R, and plateletcrit were statistically positively correlated with FBG whereas RBC count, Hgb, hematocrit, MCV, MCH, and RDW-SD were statistically negatively correlated with FBG in T2DM patients. Moreover, total WBC count, neutrophil count, monocyte count, basophil count, Hgb, and plateletcrit were statistically positively correlated with BMI while RBC count, Hgb, hematocrit, MCV, MCH, and RDW-SD were statistically negatively correlated with BMI in T2DM patients. On the other hand, DBP was significantly positively correlated with platelet count and RDW-CV whereas SBP also significantly positively correlated with total WBC count, neutrophil count, basophil count, and PDW. Besides, DBP and SBP showed statistically significant negative correlations with RBC count, Hgb level, and Hct value in T2DM patients. The overall prevalence of anemia was 25.8% in T2DM patients with a higher prevalence of anemia (16.7%) in female patients. Multivariate logistic regression revealed that being non-employee worker (AOR: 3.6, 95% CI, 1.4–46.0, P = 0.002), presence of neuropathy (AOR: 13.40, 95% CI, 6.83–26.28, P = 0.00), and duration of the disease ≥ 5 years (AOR = 3.2, 95% CI, 1.2–15.3, P = 0.03) have had statistically significant association with anemia inT2DM patients. Conclusions Patients with T2DM may have significant alterations in various hematological parameters. Hematological parameters should be regularly tested for early diagnosis and proper management of diabetes-related complications.

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Section: Discussionsupporting

confidence: 91%

Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study

Ebrahim

Fiseha

Ebrahim³

et al. 2022

PLoS ONE

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“…Although the percentage of patients with leukocytosis is not stated, previous research has shown that leukocytosis is a common symptom in patients with T1DM. Findings from studies conducted in Ethiopia, 36 Nigeria, 37 and Bangladesh 38 confirm that the mean value of total WBC count was higher in patients with DM than in non-diabetic controls. The increase in WBC count mainly reflects the elevated neutrophil and lymphocyte count in these studies.…”

Section: Discussionmentioning

confidence: 90%

“…This is similar to a study done in Ethiopia which report that platelet counts were significantly higher in patients with DM than in the controls. 36 Besides, studies have shown that there is no significant difference in the mean platelet count between children with T1DM and healthy controls. 25 , 35 Possible mechanisms for the increased platelet count in DM are related to hyperglycemia, insulin deficiency and resistance, and associated metabolic cellular abnormalities and therefore increase the risk of thrombotic and vascular complications.…”

Section: Discussionmentioning

confidence: 99%

Hematological abnormalities among adults with type 1 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital

Getawa

Adane

2022

SAGE Open Medicine

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Objective: Changes in the blood cell function, metabolism, and the coagulation system were associated with diabetes mellitus. This study aimed to determine the magnitude and associated factors of hematological abnormalities in adults with type 1 diabetes mellitus. Methods: A total of 204 medical charts of adults with type 1 diabetes mellitus who registered for follow-up at the University of Gondar Comprehensive Specialized Hospital were reviewed from June to August 2021. Data were collected using a structured data extraction checklist. To identify factors associated with hematological abnormalities, both bivariate and multivariate logistic regression analyses were done. Statistical significance was defined as a p-value of <0.05. Results: The overall magnitude of leukocytosis and anemia in adults with type 1 diabetes mellitus was 76.0% (95% confidence interval: 70.07–81.89) and 30.90% (95% confidence interval: 24.49–37.28), respectively. Neutrophilia and lymphocytosis were the common white blood cell abnormalities detected in 53.43% (95% confidence interval: 46.53–60.33) and 43.63% (95% confidence interval: 36.76–50.49) of the patients, respectively. Besides, thrombocytosis and thrombocytopenia were observed in 5.4% (95% confidence interval: 2.27–8.52) and 10.3% (95% confidence interval: 6.09–14.5) of the patients, respectively. Only being male (adjusted odds ratio = 2.28 (95% confidence interval: 1.46–5.29)) and duration of diabetes mellitus (⩾3 years) (adjusted odds ratio = 8.41 (95% confidence interval: 2.49–28.29)) were significantly associated with anemia and leukocytosis, respectively. Conclusion: Hematological abnormalities, particularly anemia and leukocytosis, are common in patients with type 1 diabetes mellitus. Therefore, preventive and control strategies for hematological abnormalities are essential in patients with type 1 diabetes mellitus particularly for male and patients with a long duration on diabetes mellitus to reduce the burden and related complications.

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“…Diabetes mellitus is a group of metabolic disorders characterized by abnormal carbohydrate metabolism resulting in chronic hyperglycemia caused by defective insulin production [1]. Several studies have shown that T2DM predisposes to a multifactorial prothrombotic state, in which endothelial dysfunction, platelet hyper-reactivity, alterations of the coagulation cascade, impaired fibrinolysis, as well as chronic low-grade inflammation, are known to play a major role [2].…”

Section: Introductionmentioning

confidence: 99%

Platelet Indices and Neutrophil/ Lymphocyte Ratio in Type 2 Diabetes Mellitus and their Correlation with Glycemic Control

2022

Al-Azhar University Journal of Virus Researches and Studies

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Diabetes mellitus (DM) is the most challenging problem in today's world, it is a complex disease characterized by chronic hyperglycemia, metabolic abnormalities, and long-term macro and micro vascular complications. Type 2 diabetes mellitus (T2DM) accounts for over 80% of cases of DM. HbA1c is a more useful marker to determine mean blood glucose levels over a long time period. This study aims to assess changes in platelet indices and neutrophil / lymphocyte ratio in type 2 diabetes mellitus and their correlation with diabetic control. It is single center study, patients were selected from the outpatients and inpatients of the Endocrinology Department at Al-Zahraa University Hospital, through the period from February 2021 to July 2021. The study was conducted on 40 cases with type 2 diabetes mellitus which divided into two subgroups, group A (n=19) controlled diabetes (HbA1C <7%) and group B (n= 21) patients with uncontrolled diabetes (HbA1C >7%) in parallel with 40 apparently healthy individuals. For all subjects, platelet indices, and neutrophil/ lymphocyte ratio (NLR), prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin (PTT) time were investigated. In this study, a significant increase in mean platelet volume (MPV) and PTT were observed in the diabetic group in comparison to the control group. There was a significant increase in WBCs and lymphocyte count between controlled and uncontrolled diabetes. while there was no statistically significant difference of PLTs, MPV, PDW, PCT, NLR, PTT, PT, & INR between controlled and uncontrolled diabetes. Our study revealed that a significant increase in MPV in diabetic patients additionally there is a significant positive correlation between HbA1C and MPV , in addition, changes in coagulation profile (specially PTT) contribute to the thrombotic state in diabetes mellitus.

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White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 18 publications

References 42 publications

Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study

Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study

Hematological abnormalities among adults with type 1 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital

Platelet Indices and Neutrophil/ Lymphocyte Ratio in Type 2 Diabetes Mellitus and their Correlation with Glycemic Control

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