Platelet distribution width, platelet count, and plateletcrit in diabetic retinopathy

Abstract

Background: Screening and diagnosis of diabetic retinopathy (DR) mainly depends on fundus examination, which is not an intuitive and simple screening or diagnostic method. Recently, the relationship between platelet parameters and DR has become a hot topic. Whether platelet parameters have clinical value in DR is controversial. Methods: Literature was retrieved by formal search of electronic databases (PubMed, Embase, Cochrane library, Scopus, and CNKI) and by hand searching of reference lists of related articles from the beginning of building database to December 2017. Review manager 5.3 was utilized to deal with statistical data. This study was registered at International Prospective Register of Systematic Reviews (number: CRD42018093773). Results: This study included 1720 DR patients, 1477 type 2 diabetic mellitus (T2DM) without DR patients and 1456 health controls in 21 eligible studies. We found there was significant increase of platelet distribution width (PDW) level in the comparison of DR versus Control group (standard mean difference [SMD] [95% confidence interval [CI]] = 1.04 [0.68, 1.40]) and DR versus T2DM without DR group (SMD [95% CI] = 0.68 [0.40, 0.95]). For platelet count (PLT), it showed obvious decrease in the comparison of DR versus T2DM without DR group (SMD [95% CI] = −0.26 [−0.49, −0.03]) and no difference in comparison of DR versus Control (SMD [95% CI] = −0.26 [−0.51, −0.00]). Subgroup analysis showed that significant result of PDW level appeared in China and Turkey in all comparisons, while similar results of PLT only in China. In addition, PDW level was different in various DR-subtypes, obvious high level in proliferation DR. Conclusions: We concluded that the guiding significance of PDW and PLT in diagnosis and monitor of DR, and especially, application of PDW to PDR management may have potential sense.

Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus

“…A similar conclusion has been found in another type of diabetic microangiopathy; namely, diabetic retinopathy. In a meta-analysis involving 4,653 participants, Ji et al 16 found an obvious decrease of the PLT level in diabetic retinopathy patients. Peripheral PLT depends on several different variables; that is, platelet production rate, mean platelet survival and the size of the exchangeable splenic platelet pool.…”

“…A similar conclusion has been found in another type of diabetic microangiopathy; namely, diabetic retinopathy. In a meta‐analysis involving 4,653 participants, Ji et al 16 . found an obvious decrease of the PLT level in diabetic retinopathy patients.…”

“…Platelet indices, such as platelet count (PLT) and plateletcrit (PCT), can reflect the function of platelets and are easily obtained in clinical practice. Notably, low PLTs have been reported in patients with diabetes, and it is likely to be associated with an increased risk of microvascular disease 15 , 16 .…”

Association of White Blood Cell Counts, Leukocyte Ratios, and Serum Uric Acid with Clinical Outcome of Intravitreal Bevacizumab in Diabetic Macular Edema

“…Both higher lymphocyte and lower platelet counts contribute to higher LPR. Platelets are known to have some physiological characteristics such as adhesion and aggregation [ 31 ]. The increased activation and aggregation of platelets are important causes of vascular complications in diabetes [ 32 ].…”

“…The increased activation and aggregation of platelets are important causes of vascular complications in diabetes [ 32 ]. In a recent meta-analysis, the authors conjectured that the consumption of platelets during coagulation attributes mainly to the decreased platelets in DR patients [ 31 ]. However, according to our findings, structural and functional outcomes of IVB therapy in DME patients were not in association with platelets’ counts.…”