Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus

Abstract

Aims/Introduction Diabetes has been considered as a ‘pro‐thrombotic state’ with enhanced platelet reactivity. Abnormality in platelet aggregation has been found in patients with its most common chronic complication – diabetic peripheral neuropathy (DPN). The purpose of this study was to investigate the potential association of platelet indices with nerve conduction function and the presence of DPN in Chinese patients with type 2 diabetes mellitus. Materials and Methods This study involved a total of 211 inpatients with type 2 diabetes mellitus and 55 healthy individuals for whom nerve conduction studies were carried out. DPN was diagnosed according to the American Diabetes Association recommendation. Clinical data were retrospectively collected. Results Patients with diabetes in whom neuropathy developed had lower levels of platelet count (PLT) and plateletcrit (PCT) than healthy controls (P < 0.05). Statistically significant associations of low PLT and PCT levels with the reduction of summed amplitude/velocity Z‐score, and the prolongation of F‐wave minimum latency in nerve conduction studies were found. Furthermore, after multivariate adjustment, logistic regression analysis showed that low levels of PLT (odds ratio 2.268, 95% confidence interval 1.072–4.797; P < 0.05; PLT <226 vs PLT ≥226) and PCT (odds ratio 2.050, 95% confidence interval 1.001–4.201; P < 0.05; PCT <0.222 vs PCT ≥0.222) in type 2 diabetes mellitus patients were risk factors for the presence of DPN. Conclusions Lower PLT and PCT levels are closely associated with poorer peripheral nerve conduction functions and the presence of neuropathy in patients with type 2 diabetes mellitus, which suggests that PLT and PCT might be potential biomarkers for showing DPN.

New Hematological Parameters as Inflammatory Biomarkers: Systemic Immune Inflammation Index, Platerethritis, and Platelet Distribution Width in Patients with Adult Attention Deficit Hyperactivity Disorder

“…According to our reviews in the literature, there has been no publication on PCT change in ADHD. In recent publications evaluating the relationship between diabetic neuropathy and PCT, the correlation of a lower PCT level with a slower nerve conduction rate and a higher rate of diabetic neuropathy has been reported(Qian et al, 2021 ). Our finding suggests that thrombocytcrit (PCT) has effects on attention and may indicate high expression of subunits that are majorly expressed in α 3 GABA A receptors, and monoaminergic and cholinergic basal forebrain cells, with GABAergic, acetylcholinergic, or any mechanical connection (Mohler, 2007 ).…”

“…It is determined by the combination of PLT and MPV (PLT × MPV), thus providing more accurate information than PLT or MPV alone (Sahbaz et al, 2016 ). PCT is a new, simple, inexpensive, and also easily obtainable biomarker of the inflammatory response of change in PLT and MPV levels (Qian et al, 2021 ).…”

Association of Elevated Serum Uric Acid with Nerve Conduction Function and Peripheral Neuropathy Stratified by Gender and Age in Type 2 Diabetes Patients

“…All patients we enrolled underwent a detailed neurological assessment at admission. The neuropathy disability score (NDS) and neuropathy symptom score (NSS) were conducted to confirm the presence of neuropathic deficits and neuropathy symptoms by an experienced neurologist as described in our previous study [ 21 ]. The NDS evaluated pinprick sensation, temperature perception, Achilles reflex, and vibration sense [ 22 , 23 ].…”

Oral Peroxisome Proliferator-Activated Receptor-Alpha (PPAR)-α Agonist Enhances Corneal Nerve Regeneration in Patients with Type II Diabetes Mellitus

“…Peer Review Only Diabetes with type II DM(60). Collectively, these suggest that the suppression of inflammation and platelet activation are possible mechanisms of fenofibrate.…”