Clinical relevance of contact sensitization in atopic dermatitis

Ingordo, Vito; D’Andria, Giuliano; D’Andria, Corrado; Cusano, Francesco

doi:10.1034/j.1600-0536.2001.450413.x

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…With regard to whether AIs tend to develop allergic contact sensitization as frequently as NAIs, our study demonstrated that atopic subjects had statistically significantly more positive patch tests than NAIs (1.52 and 1.26 in the AI and NAI groups, respectively; P = 0.006). Other studies have made similar findings, showing that AIs are at least as likely to have ACD as NAIs 6–8 …”

Section: Discussionmentioning

confidence: 61%

“…Other studies have made similar findings, showing that AIs are at least as likely to have ACD as NAIs. [6][7][8] Considerable differences between AIs and NAIs were observed in regard to some of the most frequent sensitizers, such as potassium dichromate, phenylmercuric acetate, triclosan, and wool alcohol. This finding was statistically significant for potassium dichromate and phenyl mercuric acetate.…”

Section: Discussionmentioning

confidence: 99%

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Contact sensitization pattern in 172 atopic subjects

et al. 2011

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Contact sensitization pattern in 172 atopic subjects

et al. 2011

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“…12,13 Recent studies, however, show that atopic individuals are at least as likely to develop ACD compared to nonatopic individuals. [14][15][16][17][18][19][20][21] Additionally, lack of functional filaggrin has been shown to increase the risk of ACD in patients with AD. 22,23 As can be expected from frequent exposition to allergens in topical therapy, allergies to lanolin alcohols and antiseptics occur regularly within patients with AD.…”

Section: Introductionmentioning

confidence: 99%

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Boonstra

Rustemeyer

Middelkamp-Hup

2018

Acad Dermatol Venereol

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BackgroundConcomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult‐to‐treat. However, contact sensitization in this patient group has barely been studied.ObjectiveTo study the occurrence of ACD in a population of difficult‐to‐treat AD children and adults.MethodsClinical and patch test information of 48 patients with difficult‐to‐treat AD unresponsive to conventional outpatient treatments was gathered retrospectively. We studied prevalence and relevance of common allergens, performed dynamic patch test analysis and assessed occurrence of polysensitization.ResultsIn 48 patients with difficult‐to‐treat AD, 75% (n = 36/48) had a concomitant contact allergy, and 39% (n = 14/36) of these patients were polysensitized. ACD and polysensitization prevalences were equal amongst children and adults. The most frequent and relevant reactions were seen against wool alcohols, surfactants cocamidopropyl betaine and dimethylaminopropylamine, bichromate and fragrance mix I. Dynamic pattern analysis showed these reactions to be mostly allergic and not irritative of nature.ConclusionDifficult‐to‐treat AD patients frequently suffer from concomitant (multiple) contact allergies, and this may be a reason why the AD turns into a difficult‐to‐treat disease. Awareness of this phenomenon is necessary, as pragmatic implementation of allergen avoidance strategies may be helpful in getting disease control in this population.

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“…DeGroot found that in adult patch test patients, atopics were less likely to be sensitized to common contact allergens than non‐atopics (1). Ingordo et al found no significant difference in the likelihood of sensitization to common allergens in a group of patients with AE versus non‐atopics (2). A previous study from this institute showed that in hairdressers with hand eczema, there was no significant difference in the likelihood of sensitization to hairdressing allergens or to nickel between atopics and non‐atopics (3).…”

mentioning

confidence: 99%