Contact sensitization pattern in 172 atopic subjects

Landeck, Lilla; Schalock, Peter C.; Baden, Lynn A.; González, Ernesto

doi:10.1111/j.1365-4632.2010.04754.x

Cited by 23 publications

(21 citation statements)

References 18 publications

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“…In previous studies, where only a selected group of wool alcohol derivatives have been tested, lower numbers of wool alcohol sensitization were found 14, 17, 20, 26. However, also prevalences of 24% wool alcohol sensitization have been reported previously 47.…”

Section: Discussionmentioning

confidence: 86%

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Boonstra

Rustemeyer

Middelkamp-Hup

2018

Acad Dermatol Venereol

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BackgroundConcomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult‐to‐treat. However, contact sensitization in this patient group has barely been studied.ObjectiveTo study the occurrence of ACD in a population of difficult‐to‐treat AD children and adults.MethodsClinical and patch test information of 48 patients with difficult‐to‐treat AD unresponsive to conventional outpatient treatments was gathered retrospectively. We studied prevalence and relevance of common allergens, performed dynamic patch test analysis and assessed occurrence of polysensitization.ResultsIn 48 patients with difficult‐to‐treat AD, 75% (n = 36/48) had a concomitant contact allergy, and 39% (n = 14/36) of these patients were polysensitized. ACD and polysensitization prevalences were equal amongst children and adults. The most frequent and relevant reactions were seen against wool alcohols, surfactants cocamidopropyl betaine and dimethylaminopropylamine, bichromate and fragrance mix I. Dynamic pattern analysis showed these reactions to be mostly allergic and not irritative of nature.ConclusionDifficult‐to‐treat AD patients frequently suffer from concomitant (multiple) contact allergies, and this may be a reason why the AD turns into a difficult‐to‐treat disease. Awareness of this phenomenon is necessary, as pragmatic implementation of allergen avoidance strategies may be helpful in getting disease control in this population.

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Section: Discussionmentioning

confidence: 86%

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Boonstra

Rustemeyer

Middelkamp-Hup

2018

Acad Dermatol Venereol

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“…Furthermore, increased reactivity to self-antigens, 5,140-143 irritants, 117,118,145 and allergens 123,126,129 was correlated with AD disease activity, supporting their role in perpetuating chronic inflammation. Thus endogenous AD inflammation might involve a breach of tolerance through mechanisms similar to those involved in ACD.…”

Section: A Disturbed Barrier Promotes Immune Activation: Experimentalmentioning

confidence: 85%

“…11,123-125 A more recent study has reported significantly higher sensitization rates (65.0%) in atopic subjects compared with those seen in nonatopic subjects (57.4%). 126 …”

Section: A Disturbed Barrier Promotes Immune Activation: Experimentalmentioning

confidence: 99%

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Gittler

Krueger

Guttman‐Yassky

2013

Journal of Allergy and Clinical Immunology

191

130

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Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.

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“…[12][13][14] Recent studies found increased ACD frequency in patients with AD [15][16][17] and showed that both the severity and duration of AD are correlated with ACD in atopic children. 18 Increased prevalences of polysensitization and contact sensitization to fragrances (ie, balsam of Peru) 12,19 and metals were also shown in patients with AD.…”

mentioning

confidence: 98%

Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin

Rosa

Malajian

Shemer³

et al. 2015

Journal of Allergy and Clinical Immunology

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Contact sensitization pattern in 172 atopic subjects

Abstract: Atopic individuals were shown to be at least as likely to have ACD as NAIs. The most common sensitizers were similar in both groups, suggesting common sources of sensitization.

Cited by 23 publications

References 18 publications

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin

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