Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Gittler, Julia K.; Krueger, James G.; Guttman‐Yassky, Emma

doi:10.1016/j.jaci.2012.06.048

Cited by 191 publications

(137 citation statements)

References 188 publications

(274 reference statements)

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“…Active skin disease, such as ADs or even irritant contact dermatitis, disturbs the integrity of the epidermal barrier. So that potential chemical allergens access easily to the immune system and trigger the reaction process of allergic contact dermatitis (18).…”

Section: Discussionmentioning

confidence: 99%

Influence of Age on Patch Tests Results

Mahfoudh¹,

Elmaleel²,

Kalboussi³

et al. 2017

tdd

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Amaç: Yama test sonuçları üzerinde yaşın etkisini incelemek ve yaş gruplarına göre deri duyarlaştırıcılarının profillerini karşılaştırmaktır. Yöntemler: Bu sekiz yıllık retrospektif çalışma, Tunus, Sousse Üniversite Hastanesi, Meslek Hekimliği Bölümü, Dermatoloji ve Alergoloji Ünitesi'nde alerjik kontakt dermatit hastalarının tüm tıbbi kayıtlarını içermektedir. Çalışma popülasyonu iki yaş grubuna ayrıldı (grup 1: <40 yaş hastalar; grup 2: >40 yaş hastalar). İstatistiksel anlamlılık derecesi p<0,05 olarak kabul edildi. Bulgular: Beş yüz altmış sekiz hasta en az bir yama testine pozitif reaksiyon vermiştir. Yaşlı bireylerin en az bir yama testine pozitif yanıt vermeleri gençlere göre 1,1 kat daha muhtemeldir. İki grupta da görülen en yaygın alerjenler: potasyum dikromat (%34,2, %38), tiuram karışımı (%6, %11), kobalt klorür (%27, %28,8), Peru balsamı (%6, %11,3) ve nikel sülfattır (%41, %27,3). Potasyum dikromat ile deri reaksiyonlarının intansitelerinde belirgin bir varyasyon not edildi (p=0,00). Sonuç: Yama test sonuçları üzerinde yaş etkisinin fizyolojik mekanizmasının aydınlığa kavuşturulması ve European Standard Battery'yi alerji tipi ve uygun konsantrasyonlar açısından her yaş grubuna uyarlamak için daha fazla çalışmaya gereksinim vardır. Anahtar kelimeler: Yama testleri, alerjen, dermatit, yaş, deri reaksiyonları, deri Öz AbstractObjective: To assess the influence of age on the patch-test results and to compare the profiles of skin sensitizers according to the age groups. Methods: It is an 8-year retrospective study involving entire medical records of the patients with allergic contact dermatitis at the Unity of Dermatology and Allergology in the Department of Occupational Medicine, University Hospital of Sousse in Tunisia. Study population was divided into two age groups (group 1: patients <40 years; group 2: patients >40 years). The statistical significance level was taken as p<0.05. Results: Among the patients, 586 have had at least one positive reaction to the patchtest. Older individuals were 1.1 times more likely to have at least one positive reaction to the patch-test than younger ones. The most common allergens in both groups are potassium dichromate (34.2% vs. 38%), thiuram mix (6% vs. 11%), cobalt chloride (27% vs. 28.8%), balsam of Peru (6% vs. 11.3%) and nickel sulphate (41% vs. 27.3%). A significant variation was noted for potassium dichromate in terms of intensity of skin reaction (p=0.00). Conclusion: More research is needed to elucidate the physiologic mechanisms of age on the patch-test results and to adapt the European Standard Battery to each age group in term of allergen type and their appropriate concentration.

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Section: Discussionmentioning

confidence: 99%

Influence of Age on Patch Tests Results

Mahfoudh¹,

Elmaleel²,

Kalboussi³

et al. 2017

tdd

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“…When reexposed to the allergen, antigen-specific T cells are activated through the release of cytokines and induce an inflammatory process 46) . AD is characterized by frequent itching, severe drying and eczematous skin lesions with infiltration of immune cells 47) .…”

Section: ⅳ Discussionmentioning

confidence: 99%

Effects of Torilis japonica Extract on DNCB-induced Contact Dermatitis in BALB/c Mice

Lee¹,

Song²,

Hong³

2016

The Journal of Korean Medicine Ophthalmology and Otolaryngology

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“…In chronic AD, several underlying features are invariably present: 1) increased skin infiltration by T-cells (approx. 10-fold increase over background T-cell levels in normal skin); 2) increased skin infiltration by myeloid (CD11c+) dendritic cells (DCs) (also approx.10-fold increase over normal skin levels), with most DCs having an "inflammatory phenotype" (BDCA1-/CD11c+) (74); 3) increased production of cytokines and chemokines by activated T-cells and DCs within skin lesions, as measured by quantitative mRNA measures for individual molecules, and by immunohistochemical detection of associated protein products in skin lesions; and 4) reactive epidermal hyperplasia or "regenerative maturation," showing an unusual hyperplasia response in which mRNAs and proteins of epidermal cornification are highly suppressed in the associated epidermis (21,(75)(76)(77).…”

Section: Complex Causes Of Epithelial Skin Barrier Dysfunction In Admentioning

confidence: 99%

Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches

2014

Journal of Allergy and Clinical Immunology

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Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often precedes the development of food allergy and asthma. Recent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and systemic IgE sensitization. Atopic skin is also predisposed to colonization or infection by pathogenic microbes, most notably Staphylococcus aureus and herpes simplex virus (HSV). Causes of this abnormal skin barrier are complex and driven by a combination of genetic, environmental and immunologic factors. These factors likely account for the heterogeneity of AD onset, severity and natural history of this skin disease. Recent studies suggest prevention of AD can be achieved by early interventions protecting the skin barrier. Onset of lesional AD requires effective control of local and systemic immune activation for optimal management. Early intervention may improve long term outcomes for AD and reduce the systemic allergen sensitization leading to associated allergic diseases in the gastrointestinal and respiratory tract.

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Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Cited by 191 publications

References 188 publications

Influence of Age on Patch Tests Results

Influence of Age on Patch Tests Results

Effects of Torilis japonica Extract on DNCB-induced Contact Dermatitis in BALB/c Mice

Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches

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