Atopy and contact allergy to fragrance: allergic reactions to the fragrance mix I (the Larsen mix)

Abstract

We found no association between atopy and allergy to FM I. There has been a marked increase in atopy in individuals referred for patch testing in the past 25 years.

Contact sensitization to common haptens is associated with atopic dermatitis: new insight

“…The positive association between AD and contact sensitization in our study was driven mainly by fragrance chemicals. This finding conflicts with previous findings based on patch‐tested patients with dermatitis: a British study including 34 072 patients 22 and a German study including 59 298 patients 23 found no difference in the prevalence of fragrance sensitization in patients with dermatitis with or without AD. However, another large German study found a significantly higher prevalence of fragrance mix I sensitization in patients with AD when compared with controls 24 .…”

Fragrance contact allergy in Iran

“…, 18 no significant association between fragrance allergy and AD was found in the present study. While, the proportion of the patients with positive patch test reactions to FM I among those who had AD [19/220 (8.6%)] is comparable with another study [141/1839 (7.7%)], 27 in the present study, a statistically significant difference between the proportion of patients with positive patch test reactions to FM I among non‐atopics [22/917 (2.4%)] and the proportion observed in atopics [19/220 (8.6%)] was detected ( P < 0.0001). This difference may be partly explained by a higher proportion (>50%) of atopic cases that were patch tested by Buckley et al.…”

“…This difference may be partly explained by a higher proportion (>50%) of atopic cases that were patch tested by Buckley et al. 27 in their clinic.…”

Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study

“…Regarding atopy, its role in the induction of allergic contact dermatitis, especially for fragrance haptens, has been widely debated. However, as shown for FM I , atopy does not appear to confer an overall increased risk of sensitization to the terpene hydroperoxides, as only 20% of patients with allergic reactions to limonene and/or linalool had atopic features.…”