Clinical manifestations of atopy in children up to two years of age

Abstract

Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

Campylobacter jejuni infection and IgE sensitization in up to 2-year-old infants

“…In our study group, 68.6% of the children with C. jejuni infection had a combination of IgM+IgG classes, and in all combinations of antibodies the IgM class was always present. In several studies the tIgE serum level is described as the marker of atopy, now widely used in the diagnosis of allergic diseases in children 29,30 . Atopy is a subgroup of allergic hypersensitivities and is defined as a genetic predisposition for IgE production in response to exposure to allergens.…”

“…Lower IgM serum levels against C. je uni detected in the atopic children can indicate a weaker immune response which does not correlate with the -1/ -2 ratio. Several studies determined increased levels of the total IgE in a group of sensitized children, but the cut-off values of the total IgE implying the presence of atopy in early childhood varied, ranging from 15.15 kU/L to 106 kU/L 29,30 . Occurrence of specific IgE antibodies to allergens lies in the basis of the development of a clinical disorder (phenotype) of an atopic disease 27,28 .…”

Chronic Urticarial in Childhood. Immune Pathology of Chronic Urticarial in Children (Part I)

“…Таким образом, повышение IgE общего не яв-ляется специфичным признаком у детей с хрони-ческим течением крапивницы, поскольку требует ряда уточняющих факторов, а именно -пол, воз-раст, наличие других атопических заболеваний, сопутствующих инфекций [44]. В сравнительных исследованиях острой и хронической крапивни-цы у детей Chang K.L.…”