Campylobacter jejuni infection and IgE sensitization in up to 2-year-old infants

Atopic individuals tend to develop a Th2 dominant immune response, resulting in hyperresponsiveness to harmless antigens, termed allergens. In the last decade, epidemiological studies have emerged that connected allergy with a deficient iron-status. Immune activation under iron-deficient conditions results in the expansion of Th2-, but not Th1 cells, can induce class-switching in B-cells and hampers the proper activation of M2, but not M1 macrophages. Moreover, many allergens, in particular with the lipocalin and lipocalin-like folds, seem to be capable of binding iron indirectly via siderophores harboring catechol moieties. The resulting locally restricted iron-deficiency may then lead during immune activation to the generation of Th2-cells and thus prepare for allergic sensitization. Moreover, iron-chelators seem to also influence clinical reactivity: mast cells accumulate iron before degranulation and seem to respond differently depending on the type of the encountered siderophore. Whereas deferoxamine triggers degranulation of connective tissue-type mast cells, catechol-based siderophores reduce activation and degranulation and improve clinical symptoms. Considering the complex interplay of iron, siderophores and immune molecules, it remains to be determined whether iron-deficiencies are the cause or the result of allergy.

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Linking iron-deficiency with allergy: role of molecular allergens and the microbiome

Roth‐Walter

Pacios

Bianchini

et al. 2017

Metallomics

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Research Progress of Relationship between Intestinal Flora and Allergic Diseases

Wang

2019

E3S Web Conf.

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Allergic diseases are the major health problems in the world today. The abnormal structure of intestinal flora is closely related to the occurrence and development of allergic diseases. The formation process of intestinal flora structure in early life is affected by various factors such as delivery mode, feeding mode, addition of probiotics or prebiotics, and heredity, etc. Moreover, the abnormal intestinal flora structure in early life is an important influencing factor for later allergic diseases. In this paper, the relationship between early intestinal flora structure abnormality and the occurrence and development of allergic diseases is discussed in combination with the latest literature.

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Campylobacter jejuni infection and IgE sensitization in up to 2-year-old infants

Abstract: C. jejuni infection increases the total serum IgE level, which is pre- dictive of infection, regardless of the presence of atopy. The presence of symptomatic C. jejuni infection reduces the risk of atopy in a child of the age of 5-24 months by the factor of 10.

Cited by 2 publications

References 31 publications

Linking iron-deficiency with allergy: role of molecular allergens and the microbiome

Linking iron-deficiency with allergy: role of molecular allergens and the microbiome

Research Progress of Relationship between Intestinal Flora and Allergic Diseases

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