Clinical features and outcomes of secondary intraocular lymphoma

Karakawa, Ayako; Taoka, Kazuki; Kaburaki, Toshikatsu; Tanaka, Rie; Shinozaki‐Ushiku, Aya; Hayashi, Hiroyuki; Miyagi-Maeshima, Akiko; Nishimura, Y; Uekusa, Toshimasa; Kojima, Yoshitsugu; Fukayama, Masashi; Kurokawa, Mineo; Aihara, Makoto

doi:10.1111/bjh.15005

Cited by 19 publications

(23 citation statements)

References 10 publications

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“…Only a few published series describe and compare different subtypes of IOLs. Among IOLs, PVRL is the most described type of IOL by far, accounting for 72% as recently described [7] and 52% in our study. PUL are described rarely and usually excluded in IOL series, or reported separately [4, 8].…”

Section: Discussionsupporting

confidence: 68%

Clinical Features of Primary and Systemic Metastatic Intraocular Lymphomas in Spanish Patients

Llorenç

Fuster

Alba‐Linero

et al. 2019

Journal of Ophthalmology

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Objectives To describe and compare clinical findings in different subtypes of biopsy-proven intraocular lymphomas (IOLs). Design Retrospective, observational case series. Methods The clinical and pathologic features in IOLs at the Hospital Clinic of Barcelona from 1995 to 2018 were retrospectively studied. Results Twenty-one patients, 12 men (57%), median age 60 (interquartile range, IQR: 18 years), and a median follow-up of 30 (IQR 60) months were included. Eleven patients had primary vitreo-retinal lymphoma (PVRL, 52%), 4 had primary uveal lymphoma (PUL, 19%), and 6 had systemic metastatic retinal lymphomas (SMRLs, 28%). Diffuse large B-cell lymphoma was the main IOL subset in PVRL (91%) and in SMRL (83%), whereas extranodal marginal zone lymphoma was the only type in PUL (100%). Survival rate was 44% in PVRL and 20% in SMRL at 5 years (p=0.047). One patient had flow cytometry of two different vitreous humour samples. With them, flow cytometry was performed in a total of 11 samples, yielding 7 positive samples. Conclusions and Relevance Even though PVRL is the most frequent IOL subtype, our findings suggest that PUL and SMRL should be considered as potential IOL causes. Overall survival was poor in PVRL and even shorter in SMRL patients.

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Section: Discussionsupporting

confidence: 68%

Clinical Features of Primary and Systemic Metastatic Intraocular Lymphomas in Spanish Patients

Llorenç

Fuster

Alba‐Linero

et al. 2019

Journal of Ophthalmology

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“…In cases of PVRL, the central nervous system is involved in 50–80% of patients, and therefore, the diagnostic focus is primarily intraocular and intracranial [1, 7]. In recent studies, SVRL associated with systemic lymphoma was found in 5–28% of patients after diagnostic vitrectomy [1, 3, 8]. Therefore, the lower prevalence of SRVL can often mislead clinicians into suspecting retinitis or vasculitis in the setting of immunosuppression from systemic lymphoma and chemotherapy, resulting in a delay of appropriate diagnosis and treatment [4, 6].…”

Section: Discussionmentioning

confidence: 99%

“…Our patient was classified by his oncologist as the ABC phenotype and analysis demonstrated positive CD19 and CD20, as well as negative CD10 on flow cytometry. IGH gene rearrangement analysis was positive, which is typical for vitreoretinal DLBCL [3, 8]. Karakawa et al have suggested that the high correlation between SVRL and systemic ABC DLBCL may indicate a specific tropism for intraocular tissues [8].…”

Section: Discussionmentioning

confidence: 99%

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Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma

Fan

Tran

Harbour

et al. 2019

J Ophthal Inflamm Infect

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Vitreoretinal lymphoma as the presenting diagnosis in association with a systemic lymphoma without central nervous system involvement is exceedingly rare, and the classification of this condition is not well-established. Here, we describe a patient with intermittent blurry vision in the left eye for 2 years in the setting of a recent incidental diagnosis of diffuse large B cell lymphoma from an axillary lymph node biopsy. The diagnosis of panuveitis with an extensive exudative retinal detachment was made. The patient was treated with pars plana vitrectomy as well as systemic chemotherapy, intrathecal methotrexate, intravitreal methotrexate, and intravitreal rituximab with good post-operative outcomes.

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“…Although not directly generated in the retina, some cases of intraocular lymphoma affect the eye secondarily by metastasis, which tend to migrate to the retinal ganglion cell layer or can be originated within the eye and cause visual diseases [36]. It has been stated in the literature that curcumin possesses anticancer activity, because of the combination of its antioxidant, anti-inflammatory proapoptotic, immunomodulatory and anti-angiogenic properties [37].…”

Section: Eye Antitumor Activity (Retinal and Choroidal Tumors)mentioning

confidence: 99%

Curcumin as a Therapeutic Option in Retinal Diseases

et al. 2020

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The retina is subjected to oxidative stress due to its high vascularization, long time light exposition and a high density of mitochondria. Oxidative stress can lead to pathological processes, like cell apoptosis, angiogenesis and inflammation ending in retinal pathologies. Curcumin, a major bioactive component obtained from the spice turmeric (Curcuma longa) rhizome has been used for centuries in Asian countries for cooking and for curing all kinds of diseases like dysentery, chest congestion and pain in general, due to its antioxidant effects. Curcumin prevents the formation of reactive oxygen species and so it is a good protective agent. Curcumin has shown also anti-inflammatory, and antitumor properties. Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties. Some drawbacks are its poor solubility, bioavailability and lack of stability at physiological conditions; which have been shown in curcumin skeptical publications. In this review, we provide some lights and shadows on curcumin administration on the major retinal pathologies.

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Clinical features and outcomes of secondary intraocular lymphoma

Cited by 19 publications

References 10 publications

Clinical Features of Primary and Systemic Metastatic Intraocular Lymphomas in Spanish Patients

Clinical Features of Primary and Systemic Metastatic Intraocular Lymphomas in Spanish Patients

Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma

Curcumin as a Therapeutic Option in Retinal Diseases

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