Clinical Features of Primary and Systemic Metastatic Intraocular Lymphomas in Spanish Patients

Abstract

Objectives To describe and compare clinical findings in different subtypes of biopsy-proven intraocular lymphomas (IOLs). Design Retrospective, observational case series. Methods The clinical and pathologic features in IOLs at the Hospital Clinic of Barcelona from 1995 to 2018 were retrospectively studied. Results Twenty-one patients, 12 men (57%), median age 60 (interquartile range, IQR: 18 years), and a median follow-up of 30 (IQR 60) months were included. Eleven patients had primary vitreo-retinal lymphoma (PVRL, 52%), 4 had primary uveal lymphoma (PUL, 19%), and 6 had systemic metastatic retinal lymphomas (SMRLs, 28%). Diffuse large B-cell lymphoma was the main IOL subset in PVRL (91%) and in SMRL (83%), whereas extranodal marginal zone lymphoma was the only type in PUL (100%). Survival rate was 44% in PVRL and 20% in SMRL at 5 years (p=0.047). One patient had flow cytometry of two different vitreous humour samples. With them, flow cytometry was performed in a total of 11 samples, yielding 7 positive samples. Conclusions and Relevance Even though PVRL is the most frequent IOL subtype, our findings suggest that PUL and SMRL should be considered as potential IOL causes. Overall survival was poor in PVRL and even shorter in SMRL patients.

Anterior segment involvement in Epstein–Barr virus: a review

“…In case of orbital infiltration (proptosis, ophthalmoplegia, pupillary disfunction, low visual acuity, among others), the risk of metastasis is high (Llorenç et al. 2019).…”

Vitreoretinal Lymphoma

“…In the immunosuppressed, it is not unusual for VRL to present at a younger age. Some authors have reported a slight male gender predilection, with the male/female ratio of 1.2-1.7:1 [53], while more recent publications found a slight female predominance [7,40,52,54].…”

“…Occasionally patients may present with large clumps of malignant cells on the corneal endothelium, mimicking granulomatous KP (Figure 7b). Corneal edema, pseudohypopyon [54,74] and pupil distortion may be present but are not common [65]. As the anterior segment inflammation is minimal, photophobia, pain and redness are uncommon symptoms [6].…”

Primary Vitreoretinal Lymphoma: A Retrospective Study of 20 Eyes

“…PVRL most commonly represents non-Hodgkin's lymphoma (NHL), and 90% of cases have di use large B-cell lymphoma (DLBCL) [3]. e clinical features of PVRL are nonspeci c, including the presence of large, nonclumped vitreous cells and white-yellow subretinal deposits associated with solid retinal pigment epithelium (RPE) detachments [4], making it one of the most common masquerade syndromes [5,6].…”