“…Blinded clinical studies appear not to be good options to detect reductions in inhalants, especially when depth of anaesthesia is evaluated subjectively, according to clinical signs. This is of extreme importance in horses with infusions of α 2 ‐agonists, in which a “lighter” appearance, compared with traditional inhalant protocols, is common (Kalchofner et al., ). No isoflurane concentration reductions were demonstrated after romifidine (Devisscher, Schauvliege, Dewulf, & Gasthuys, ), detomidine (Schauvliege et al., ) and dexmedetomidine (Marcilla et al., ).…”