2017
DOI: 10.1111/jvp.12474
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Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

Abstract: The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be used in horses, m… Show more

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Cited by 21 publications
(23 citation statements)
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“…anaesthesia with dexmedetomidine and a volatile anaesthetic (Gozalo‐Marcilla et al . ). In man, continuous infusion of dexmedetomidine during craniotomy resulted in haemodynamic stability, reduced sevoflurane and fentanyl requirements, decreased intracranial pressure and a significantly improved outcome (Soliman et al .…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…anaesthesia with dexmedetomidine and a volatile anaesthetic (Gozalo‐Marcilla et al . ). In man, continuous infusion of dexmedetomidine during craniotomy resulted in haemodynamic stability, reduced sevoflurane and fentanyl requirements, decreased intracranial pressure and a significantly improved outcome (Soliman et al .…”
Section: Discussionmentioning
confidence: 97%
“…Dexmedetomidine reduced the MAC of sevoflurane in ponies by 53 AE 15% (Gozalo-Marcilla et al 2013), while cardiovascular function is well preserved during partial i.v. anaesthesia with dexmedetomidine and a volatile anaesthetic (Gozalo-Marcilla et al 2018). In man, continuous infusion of dexmedetomidine during craniotomy resulted in haemodynamic stability, reduced sevoflurane and fentanyl requirements, decreased intracranial pressure and a significantly improved outcome (Soliman et al 2011).…”
Section: Discussionmentioning
confidence: 99%
“…We chose to compare medetomidine with xylazine as dexmedetomidine for sedation of clinical patients proven to be not as reliable as medetomidine (6,43) and dose rates necessary to achieve good sedation before anesthesia induction were considered too variable to be a safe alternative for daily practice.…”
Section: Discussionmentioning
confidence: 99%
“…Activation of these receptors in the central nervous system results in effective sedation, analgesia, anxiety, and sympathetic effects, with minimal impact on respiratory physiological inhibition of sympathetic nerves [7]. Injecting small doses of the drug into healthy volunteers provides a sedative effect that can be easily reversed by verbal stimulation [8]. Dexmedetomidine is likely to be proven as a better sedative drug for dental sedation than midazolam for its lesser respiratory depression, lesser cognitive impairment, and shorter recovery profile and analgesic property.…”
Section: Introductionmentioning
confidence: 99%