Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses

Marcilla, Miguel Gozalo; Schauvliege, Stijn; Segaert, S.; Duchateau, Luc; Gasthuys, Frank

doi:10.1111/j.1467-2995.2011.00672.x

Cited by 58 publications

(79 citation statements)

References 28 publications

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“…Times for extubation, for sternal and standing positions also were similar between groups. Therefore, dexmedetomidine CRI did not influence the time and quality of recovery during isoflurane anaesthesia in healthy horses which was opposite to the data of Marcilla et al [17] who reported better but longer recovery when dexmedetomidine was added to isoflurane.…”

Section: Parameterscontrasting

confidence: 90%

“…This effect has been reported by other investigators [17] and resulted in elevated lactate levels. The respiratory function in horses is altered by anaesthetic drugs and bodyposition especially during dorsal recumbency.…”

Section: Parameterssupporting

confidence: 85%

“…Horses anaesthetized with isoflurane-dexmedetomidine received the total of 35 mililitres, whereas horses from ISO group were given 30 mililiters of dopamine. HR was lower compared to ISO group, a typical side effect of alpha-2 agonists that was reported by other authors [17] [21].…”

Section: Parameterssupporting

confidence: 72%

“…Administration of dexmedetomidine as an adjunctive agent to isoflurane anaesthesia produced an anaesthetic-sparing effects in human [13] [14] and dogs [15]. Its effects were studied on isoflurane anaesthetized horses by Marcilla et al [16] [17]. In the former investigation the authors found out that the two CRIs used (1 and 1.75 µg•kg −1 •hour −1 ) produced similar, small cardiopulmonary effects within an acceptable clinical range; in the former study they claimed that dexmedetomidine CRI at 1.75 µg•kg −1 •hour −1 after a bolus of 3.5 µg•kg −1 did not reduce EtIso but improved recovery quality.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Dexmedetomidine Continuous Rate Infusion (CRI) on Isoflurane Anaesthesia in Healthy Horses

Sleiman¹,

Dinev²,

Simeonova³

2016

IJCM

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The concept of the modern anaesthesiological technique partial intravenous anaesthesia (PIVA) is by means of infusion of different pharmacological agents as a supplement to inhalation anaesthetics to reduce the concentration of volatile agents maintaining surgical anaesthesia and to decrease their noxious side effects mainly on cardiovascular and respiratory systems. Alpha-2 agonists are agents with frequent use in equine practice either as sedatives or in general anaesthesia PIVA protocols. The most selective amongst them, dexmedetomidine, is characterized by fewer side effects, lower doses, and fast elimination which make it appropriate for application as a continuous rate infusion (CRI). The purpose of this study was to trace out the effects of dexmedetomidine continuous rate infusion (CRI) as part of PIVA using isoflurane on volatile agent requirements, cardiovascular function, respiration and coagulation parameters, and recovery in healthy horses. Six healthy horses with average age 9.0 ± 5.1 year and mean body weight 247.7 ± 71.4 kg were subjected to either 3-hour lasting isoflurane or isoflurane-dexmedetomidine anaesthesia two weeks apart. The main clinical and anaesthesiological parameters were monitored in 10 minutes intervals. Electrolytes, acid-base, blood gases, and coagulation parameters were measured at the beginning and at the end of each anaesthesia. Recovery times and qualities were also recorded. The results showed that, the addition of dexmedetomidine by CRI at 1.75 μg•kg −1 •hour −1 to isoflurane anaesthesia slightly reduced isoflurane requirement for maintenance of surgical anaesthesia but had negligible effects on the recovery time and quality. PIVA using dexmedetomidine and isoflurane produced respiratory acidosis similar to isoflurane anaesthesia alone but with significantly more pronounced hypoxaemia and hyperlactaemia. Both investigated anaesthesia protocols did not influence significantly haemocoagulation parameters.

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Section: Parameterscontrasting

confidence: 90%

Section: Parameterssupporting

confidence: 85%

Section: Parameterssupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Dexmedetomidine Continuous Rate Infusion (CRI) on Isoflurane Anaesthesia in Healthy Horses

Sleiman¹,

Dinev²,

Simeonova³

2016

IJCM

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show abstract

“…Due to its property to preserve respiratory function, the use of DEX is also increasing in pediatrics (Lee et al, 2007) It has marketing authorisation in small animal practice and is one of the most potent alpha-2-agonist available commercially (Marcilla et al, 2012). The positive DEX characteristics make its use advisable also in other species, such as food producing animals in which the use of drugs is restricted by the necessity to respect MRLs and withdrawal times.…”

Section: Introductionmentioning

confidence: 99%