The cardiovascular status of isoflurane-anaesthetized horses with and without dexmedetomidine constant rate infusion evaluated at equivalent depths of anaesthesia

Risberg, Åse I.; Ranheim, Birgit; Krontveit, Randi; Lervik, Andreas; Haga, Henning Andreas

doi:10.1111/vaa.12315

Cited by 20 publications

(15 citation statements)

References 26 publications

(74 reference statements)

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“…The topic of PIVA in horses and appraisal of studies into PIVA has been comprehensively reviewed elsewhere , and studies continue to be published (e.g. ). Attempting comparisons between the plethora of studies into PIVA is complicated by the usual factors associated with study design and limitations of small‐scale clinical or laboratory studies.…”

Section: Part 1: Inhaled Anaesthetic Agentsmentioning

confidence: 99%

Maintenance of equine anaesthesia over the last 50 years: Controlled inhalation of volatile anaesthetics and pulmonary ventilation

Mosing

Senior

2018

Equine Veterinary Journal

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SummaryIn the first edition of this journal, Barbara Weaver wrote a review titled 'Equine Anaesthesia', stating that, at that time, it was quickly becoming accepted practice that many horses were being anaesthetised 'by essentially similar procedures, i.e. premedication, induction and then maintenance by controlled inhalation'. To celebrate the 50th anniversary of the first edition of this journal, this review covers the development of understanding and practice of inhalational anaesthesia and controlled ventilation in horses over the last 50 years. We review how the perceived benefits of halothane led to its widespread use, but subsequently better understanding of halothane's effects led to changes in equine anaesthetic practice and the utilisation of different inhalation agents (e.g. isoflurane and sevoflurane). We discuss how more recently, better understanding of the effects of the 'newer' inhalation agents' effects has led to yet more changes in equine anaesthetic practice, and while, further new inhalation agents are unlikely to appear in the near future, further enhancements to anaesthetic practice may still lead to improved outcomes. We review advances in our understanding of the anatomy and pathophysiology of the equine lung as well of the effects of anaesthesia on lung function and how these predispose to some of the common problems of gas exchange and ventilation during anaesthesia. We identify the aims of optimal mechanical ventilation for anaesthetic management and whether the various methods of ventilatory support during equine anaesthesia achieve them. We also highlight that further developments in equipment and optimal ventilator modes are likely in the near future.

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Section: Part 1: Inhaled Anaesthetic Agentsmentioning

confidence: 99%

Maintenance of equine anaesthesia over the last 50 years: Controlled inhalation of volatile anaesthetics and pulmonary ventilation

Mosing

Senior

2018

Equine Veterinary Journal

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“…An experimental, blinded, randomized, cross‐over study with eight adults, healthy, isoflurane‐anaesthetized horses by Risberg, Ranheim, Krontveit, Lervik, and Haga () compared a PIVA protocol with dexmedetomidine (8 μg/kg for sedation followed by a 1.75 μg kg −1 hr −1 CRI) versus a saline treatment. At equivalent depths of anaesthesia (F E ′ISO 0.7% ± 0.2% and 0.9% ± 0.2%, for the dexmedetomidine and saline, respectively), statistical significant decreases in HR (16%), CI (22%) and DO 2 I (24%) and significant increases in SAP (18%), MAP (19%), DAP (18%) and oxygen extraction (OE) (32%) were present in horses receiving a CRI of dexmedetomidine compared to those receiving saline.…”

Section: Reported Studies (2005–2017)mentioning

confidence: 99%

“…It is also very important to note that all the studies involved healthy horses. While it may be discussed whether or not the reductions in cardiopulmonary function in the study of Risberg et al (2016) are of clinical importance in healthy horses, these changes may be of huge importance in colic horses.…”

Section: Bettschartmentioning

confidence: 99%

“…Finally, as the third requirement for PIVA protocols, recovery qualities after dexmedetomidine infusions are from good to excellent, with no apparent signs of excitement (Benmansour et al, 2014;Marly-Voquer et al, 2016;Risberg et al, 2016). After a CRI of dexmedetomidine during isoflurane anaesthesia, followed by a small bolus for recovery, the recoveries were better than after infusions of saline (Marcilla et al, 2012), medetomidine (Sacks et al, 2017) and morphine (Gozalo- Marcilla, Steblaj et al, 2013).…”

Section: Bettschartmentioning

confidence: 99%

“…A possible criticism to some of the studies presented in this review is that the LiDCO was used for CO measurement (Gozalo- Marcilla, Steblaj et al, 2013;Marcilla et al, 2012;Neudeck et al, 2016;Risberg et al, 2016). This method to evaluate the cardiopulmonary function is nowadays of huge value in research, mainly under clinical circumstances, due to minimal invasiveness.…”

Section: Bettschartmentioning

confidence: 99%

See 2 more Smart Citations

Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

Gozalo-Marcilla

Gasthuys

Luna

et al. 2017

Vet Pharm & Therapeutics

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The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be used in horses, mainly due to its pharmacokinetic profile and pharmacodynamics that favour its use as intravenous constant rate infusion (CRI). Nowadays, its clinical use is popular for sedation in prolonged standing procedures and during partial intravenous anaesthesia (PIVA) and total intravenous anaesthesia (TIVA). However, legal requirements for its use should be taken into account.

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Balanced Inhalation Anesthesia

Bettschart‐Wolfensberger¹,

Mama²,

Auer³

et al. 2019

Equine Surgery

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The cardiovascular status of isoflurane-anaesthetized horses with and without dexmedetomidine constant rate infusion evaluated at equivalent depths of anaesthesia

Cited by 20 publications

References 26 publications

Maintenance of equine anaesthesia over the last 50 years: Controlled inhalation of volatile anaesthetics and pulmonary ventilation

Maintenance of equine anaesthesia over the last 50 years: Controlled inhalation of volatile anaesthetics and pulmonary ventilation

Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005–2017)

Balanced Inhalation Anesthesia

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