Clinical and inflammatory features of exacerbations of occupational chronic obstructive pulmonary disease

Шпагина, Л. А.; Kotova, Olga; Шпагин, И. С.; Герасименко, О Н

doi:10.1183/1393003.congress-2017.pa416

Cited by 3 publications

(2 citation statements)

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“…The determinants of this action are harmful chemicals, dust particles that are in the air of the working zone. Aggravation of the phenotypes of professional COPD is selectively associated with the action of chemicals and dust [11]. The determinants of this action are harmful chemicals, dust particles that are in the air.…”

Section: Discussionmentioning

confidence: 99%

Influence of industrial atmospheric pollution on the development of pathology of respiratory organs

Hrebniak

Федорченко

2019

Patologìâ

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A -research concept and design; B -collection and/or assembly of data; C -data analysis and interpretation; D -writing the article; E -critical revision of the article; F -final approval of the article Due to the technogenic load, first of all, the quality of the air basin is disturbed. More than 80 % of diseases depend to some extent on its quality, but in an industrial city, atmospheric pollution determines the priority of pathology of respiratory organs.The purpose of the work was to study the peculiarities of the development of pathological conditions of the respiratory organs in the population living in conditions of significant atmospheric pollution.Materials and methods. Industrial emissions into the air basin from enterprises of the metallurgical industry were investigated. The type of violations of ventilation functions (obstruction, restriction, obstruction on the background of restriction) was determined from the "flow -volume" curve of the forced expiration. The incidence was studied according to the statistical materials of hospitals.Results. The residents of the industrial city have a complex of ecotoxicants, which leads to a dangerous degree of pollution and a very contaminated level. In 53.8 % of the city's residents there are deviations in the ventilation function (by the method of the flow -volume curve analysis) due to the development of obstructive changes in the bronchopulmonary apparatus of the upper respiratory tract. After 49 years of living in such conditions, nearly in all the population prenosological conditions are registered (91.7-93.9 %). With prolonged residence in conditions of contamination, obstruction significantly increases against the background of restriction. The incidence of respiratory diseases in adults is higher with a high level of use of production capacity.Conclusions. In 53.8 % of the inhabitants of the industrial city, there are deviations in the ventilation function due to the development of obstructive changes in the broncho-pulmonary apparatus of the upper respiratory tract (obstruction combined with a restriction and obstruction).With age, the proportion of persons with prenosological conditions of respiratory function increases, especially at the age of 30-39 and 40-49 years. A high degree correlation exists between air pollution and population morbidity. Thus, the correlation coefficient between the total city air pollution indexes and respiratory diseases is 0.72 (P < 0.01) in adults and 0.66 (P < 0.05) in children.

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Section: Discussionmentioning

confidence: 99%

Influence of industrial atmospheric pollution on the development of pathology of respiratory organs

Hrebniak

Федорченко

2019

Patologìâ

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“…Types of this pathology in modern conditions are determined, mainly, by two nosological forms: pneumoconiosis (PC) and chronic obstructive pulmonary disease (COPD). Undoubtedly, this determines the urgency of dealing with the problem of the timely diagnosis, treatment and prevention of these diseases among industrial workers [8,11].…”

Section: / Vol XXIV /mentioning

confidence: 99%

Value of roentgenologic examination in diagnostics of pneumoconiosis associated with chronic obstructive pulmonary disease in workers of the mining and metallurgical industry.

Rubtsov¹

2019

Medicni Perspektivi (Medical Perspectives)

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Value of roentgenologic examination in diagnostics of pneumoconiosis associated with chronic obstructive pulmonary disease in workers of mining and metallurgical industry. Rubtsov R.V. The aim of the research is to study the peculiarities of changes in the chest organs on the plain radiograph in pneumoconiosis associated with COPD in workers of mining and metallurgical industry. The data of clinical examination of 635 workers with lung pathology of occupational genesis are presented in the article. Group I consisted of 99 workers with pneumoconiosis associated with COPD, group II-of 21 workers with pneumoconiosis, and group III-of 515 workers with COPD of occupational etiology. A comparative analysis of radiographic changes in the chest X-ray has established that the most informative radiologic changes for pneumoconiosis associated with COPD are: linear reticular blackening up to 1.5 mm in size, cord-like blackening from 1.5 to 3.0 mm in size, and less significant changes in the form of nodules up to 1.5 mm in size, from 1.5 to 3.0 mm, thickening of pleura more than 10.0 mm in width. The most sensitive radiographic signs typical for PC associated with COPD are the indicated blackenings and nodules, their etiological share in diagnosis of this disease is 100%, determining the greatest absolute risk of development of this occupational pathology in this category of patients. The revealed X-ray diagnostic criteria allow to conduct timely diagnostics, define the tactics of treatment and prevention of PC associated with COPD in workers of mining and metallurgical industry.

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Diagnostic markers of exacerbation of chronic obstructive pulmonary disease in workers exposed to industrial aerosols and tobacco

Шпагин

Gerasimenko

Novikova

et al. 2022

Med. tr. prom. èkol.

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Introduction. Chronic obstructive pulmonary disease (COPD) is one of the most common occupational diseases registered in workers exposed to dust for a long time. This disease significantly worsens the quality of life, requires constant monitoring in the centers of occupational pathology and regular preventive measures. The proportion of COPD in the structure of occupational diseases has not changed significantly for decades, high rates of disability and premature mortality characterized this disease. The study aims to research the diagnostic parameters of COPD exacerbation under the influence of industrial aerosols and tobacco in the clinic of occupational diseases. Materials and methods. Researchers examined 153 patients with occupational COPD (toxic gases and inorganic dust). The comparison group consisted of 103 patients with smoking COPD. We established the diagnosis of COPD in accordance with the criteria of GOLD 2011. The duration of the study was 5 years. The authors conducted a complex of clinical and laboratory studies in all patients with an emphasis on the diagnostic parameters of COPD exacerbation and lung function. The critical significance level is p=0.05. Results. The development of occupational COPD under the influence of industrial aerosols and tobacco affects the frequency and predominant phenotype of exacerbations. Rare but severe exacerbations, mainly with eosinophilic type of inflammation, are present in COPD from the action of toxic gases. They respond well to therapy with systemic GCS. With COPD from the action of dust, hospitalization is not necessary for short-term exacerbations with neutrophilic type of inflammation, since such exacerbations respond to therapy with bronchodilators, and a significant proportion of exacerbations require the use of antibacterial therapy. Also, in COPD from the action of toxic gases, the experience of exposure to aerosols and gases of the production environment is an independent predictor of any exacerbations. But we do not have data on the significance of the length of service and the intensity of dust exposure. Conclusion. The risks of exacerbations of occupational COPD and the predicted features of their course depend on the etiological production factor, its intensity and duration of exposure. Clinical features determine different tactics of treatment and prevention of health deterioration. With the severity of COPD exacerbation from the action of toxic gases, symptoms of emphysema and hypoxemia are characteristic, with COPD from the action of dust, symptoms of bronchial obstruction, emphysema and hypoxemia are characteristic. Obtained results can use to construct risk meters of exacerbations and the scale of effectiveness of rehabilitation measures, to revise the standards of treatment and prevention of patients with COPD of professional genesis, as well as for the differential diagnosis of occupational obstructive pulmonary disease. Limitations. The study was conducted on the basis of Novosibirsk State Medical University and on the basis of the City Clinical Hospital No. 2. The limitations of the study may be the unidirectionality of the study performed and the small sample of patients participating in the research. Ethics. All patients have signed an informed consent form. The study program, the content of the informed consent, and the materials of the article were approved by the local ethics committee of Novosibirsk State Medical University and City Clinical Hospital No. 2.

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Clinical and inflammatory features of exacerbations of occupational chronic obstructive pulmonary disease

Cited by 3 publications

References 0 publications

Influence of industrial atmospheric pollution on the development of pathology of respiratory organs

Influence of industrial atmospheric pollution on the development of pathology of respiratory organs

Value of roentgenologic examination in diagnostics of pneumoconiosis associated with chronic obstructive pulmonary disease in workers of the mining and metallurgical industry.

Diagnostic markers of exacerbation of chronic obstructive pulmonary disease in workers exposed to industrial aerosols and tobacco

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