1975
DOI: 10.1111/j.1600-0765.1975.tb00016.x
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Clinical and histologic characteristics of normal gingiva in dogs

Abstract: The aims of the present study were to establish normal gingiva in dogs, to characterize the clinical conditions prevailing and to stereologically describe the structural composition of the normal gingival tissues. Three beagle dogs were subjected to regular oral hygiene procedures during 15 weeks. Measurements of gingival fluid flow and the amounts of crevicular leukocytes served to clinically assess the gingival conditions. Semi‐and ultrathin sections from biopsies of normal buccal gingival tissues from premo… Show more

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Cited by 68 publications
(48 citation statements)
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“…Large animals allow for the study of NMF in criticalsize defects that, by definition, do not heal spontaneously during the lifetime of the animal (Hollinger and Kleinschmidt, 1990). Another advantage of large animal models is that higher-order animals generally more closely simulate the anatomical, physiological, and pathological conditions found in humans (Schectman et al, 1972;Attström et al, 1975;Brecx et al, 1985;Hollinger and Kleinschmidt, 1990). Consequently, pre-clinical studies involving dogs and non-human primates are generally preferred by regulatory bodies for demonstration of the safety and efficacy of candidate NMF (Kaigler et al, 2010).…”
Section: Large Animal Modelsmentioning
confidence: 99%
“…Large animals allow for the study of NMF in criticalsize defects that, by definition, do not heal spontaneously during the lifetime of the animal (Hollinger and Kleinschmidt, 1990). Another advantage of large animal models is that higher-order animals generally more closely simulate the anatomical, physiological, and pathological conditions found in humans (Schectman et al, 1972;Attström et al, 1975;Brecx et al, 1985;Hollinger and Kleinschmidt, 1990). Consequently, pre-clinical studies involving dogs and non-human primates are generally preferred by regulatory bodies for demonstration of the safety and efficacy of candidate NMF (Kaigler et al, 2010).…”
Section: Large Animal Modelsmentioning
confidence: 99%
“…Attstrom et al 1 have described the histologic characteristics of normal gingiva in beagle dogs, noting that normal gingiva displayed no gingival fluid flow clinically and relatively few inflammatory cells histologically. These same authors2 have described initial gingivitis in this model.…”
mentioning
confidence: 98%
“…Fischman et al 1 determined that a 0.5% zinc citrate solution, in combination with 0.125% zinc tribromsalan significantly reduced dental plaque over a three-day period ineffective in reducing plaque formation when compared to 0.075% benzethonium chloride used as a rinse once per day over a ten-day period. Interestingly, the plaque formation observed with the addition of zinc chloride to benzethonium chloride in this study was comparable to that of the placebo group.…”
mentioning
confidence: 98%
“…Dog model is widely used for periodontal study because periodontal inflammation is common in dogs and its pathological characteristics are similar to those of periodontitis in humans [5]. Periodontitis of dogs arises naturally from gingivitis with the aging process, but the time of onset is unpredictable and the defects are inconsistent, which are considered to be the drawbacks of this model [6].…”
Section: Discussionmentioning
confidence: 99%
“…To study the phenomenon of periodontal inflammation and the effect of periodontal treatment, several animal models have been adopted [2-4]. Among these animal models, dogs are one of the commonly chosen models for periodontal study because of their high occurrence rate of periodontitis and the same etiologic factors as humans [5]. However, the natural periodontitis of dogs produces inconsistent periodontal lesions with an uneven extent and localization of periodontal inflammation [6].…”
Section: Introductionmentioning
confidence: 99%