Clinical and Antibody Responses After Influenza Immunization in Systemic Lupus Erythematosus

Abstract

After immunization with A/New Jersey/76 and A/Victoria/75 influenza vaccines, 11 patients with systemic lupud erythematosus were serially evaluated for changes in disease activity, serologic abnormalities, and their capability to generate specific antibodies. One patient, with active disease, developed a diffuse, proliferative glomerulonephritis. None of the other patients or control subjects had significant local or systemic side effects. Significant levels of antibodies were generated to A/New Jersey/76 in eight of the 11 patients and in seven of eight control subjects and to A/Victoria/75 in seven of 11 patients and five of eight control subjects. The geometric mean responses of both total and IgG antibodies to each viral antigen were no different in patients with systemic lupus erythematosus than in control subjects. In patients with stable systemic lupus erythematosus, immunization with killed influenza viral vaccine appears to be safe and effective.

Immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen.

“…Previous studies of SLE antibody response to immunization have been conflicting. SLE patients showed normal responses to immunization with influenza (22)(23)(24), TT (1), Brucella and Rickettsia (25), and had normal levels of antibodies to AB blood group antigens and Proteus OX-2 (26). In other studies, decreased SLE antibody responses were found upon immunization with influenza (27) and Brucella (28).…”

Influenza Vaccination in Autoimmune Rheumatic Disease Patients

“…Other papers reported a modest reduction or a similar humoral response in SLE patients, but compared to the healthy control group (Brodman et al 1978;Mercado et al 2004;Holvast et al 2006). In several controlled studies in SLE patients a similar humoral response was established after influenza immunization compared to the healthy control group and immunosuppressive therapy has no significant effect on the response to vaccination (Louie et al 1978;Lu et al 2011). On the other hand, there are reports indicating a decreased humoral response in SLE patients treated with immunosuppressive therapy (Abu-Shakra et al 2002;Wiesik-Szewczyk 2010).…”

Vaccination in Rheumatology: Current Aspects

“…В конце 70-х годов прошлого века в США в рамках Национальной программы по вакцинации против гриппа было выполнено пять аналогичных по дизайну исследова-ний [14][15][16][17][18], имевших целью изучить эффективность и пе-реносимость моно-и бивалентной противогриппозных вакцин у больных СКВ в неактивной фазе заболевания. В абсолютном большинстве случаев продемонстрирована высокая иммуногенность вакцины, показатели серокон-версии 1 были аналогичны таковым в контрольной группе.…”

“…Через 12 мес после вакцинации показатели сероконверсии по отноше-нию к наиболее значимым HPV-серотипам (6,11,16,18) в исследуемой и контрольной группах составили 82; 89; 95; 76 и 98; 98; 98; 80 соответственно. Лечение преднизолоном и микофенолата мофетилом ассоциировалось с более низ-ким иммунным ответом на вакцину.…”