Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects?

Abstract

Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio=2.4 vs. 1.8, p<0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio=1.6 vs. 1.1, p=0.11) and infants whose parents were first cousins (odds ratio=2.7 vs. 0.7, p=0.07). Although cleft lip with cleft palate may simply represent a more severe form of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analyses of these two groups.

Location of Cleft Lip with or without Cleft Palate Prevalence Clusters using Kulldorff Scan Statistics

“…et al 2010 [18], Harville E.W. et al 2005 [19]). As a result, the subject of residence was not entirely investigated and included in the study.…”

8 Epidemiology of Cleft Lip and Palate

“…This broad subdivision is consistent with both the distinct developmental origins of the lip/primary palate and the secondary palate and the distinct cellular and genetic etiologies described for CL/P and CPO; cleft palate may occur secondary to or independently from cleft lip. However, there is some epidemiologic evidence suggesting that cleft lip only has distinct etiologic features from cleft lip with palate and should be classified accordingly [15,16].…”

A veleszületett maxillofacialis deformitások klinikai aspektusai

“…Az ajak-, illetve a szájpadhasadék eltérő embrioló-giai hátterű [5,19,22,24]. A hasadék nagysága és kialakulásának időpontja alapján különböző súlyosságú formák képződhetnek.…”

“…A nyúlajak is érintheti a felső ajkat vagy ezen túlmenően még az alveolusokat, illetve a szájpad elülső részét [23]. A nyúlajak morfológiáját tekintve megkülönböztetünk a) mikro formát, b) inkomplett és c) komplett formát (az ajak mellett gyakran az alveolus is érintett), amelyek a genetikai háttérrel állhatnak összefüggésben [5,22,24]. A szájpadhasadék attól füg-gően is változatos morfológiájú és érintettségű lehet, hogy egy-vagy kétoldali.…”