Cisplatin impairs rat liver mitochondrial functions by inducing changes on membrane ion permeability: Prevention by thiol group protecting agents

Cisplatin Binding and Inactivation of Mitochondrial Glutamate Oxaloacetate Transaminase in Cisplatin-Induced Rat Nephrotoxicity

“…It is well known that cisplatin preferentially accumulates in the kidney, especially in the proximal tubular epithelial cells. [17][18][19][20][21][22] Our results suggest that cisplatin does not bind to liver mitochondrial GOT because cisplatin does not accumulate readily in liver tissue.…”

“…14,15) Depending on the cisplatin concentration or cellular status, tubular cell death occurs by both apoptosis and necrosis. 16) Several lines of evidence suggest that cisplatin accumulates in the mitochondria of renal cells, impairs mitochondrial bioenergetics, increases reactive oxygen species (ROS) developments, and causes the release of pro-apoptotic factors, all of which ultimately lead to renal tubular cell death, [17][18][19][20][21][22] but the mechanisms of the mitochondrial dysfunction are not yet understood. Therefore, the identification of cisplatin targets in mitochondria would be helpful to counteract cisplatininduced renal damage.…”

Light and Electron Microscopic Study on the Possible Protective Effect of Nigella Sativa Oil on Cisplatin Hepatotoxicity in Albino Rats

“…Some area of the cytoplasm showed rarefaction, lipid droplets and vacuoles. Other investigators found some of these changes [30][31][32] .…”

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

“…Recent studies have shown that different natural antioxidants such as vitamin C, vitamin E, ellagic acid, nigella sativa, lycopen, caffeic acid phenethyl ester prevent cisplatin-induced toxicity. 13,28,[32][33][34][35] In this study, we investigated the effects of the natural antioxidants GSE and OOEO in cisplatin-treated rats by microscopic examination and biochemical assays.…”

“…12 In another study, cisplatin induced mitochondrial sensitivity prevented by the thiol group of protective antioxidant agents, namely glutathione, dithiothreitol, N-acetyl-L-cysteine and cysteine, whereas SOD, catalase and ascorbate. 13 Grape seed extract (GSE) contains a number of polyphenols, including procyanidins and proanthocyanidins, which are powerful free radical scavengers. Grape seed proanthocyanidin extract is a rich source of polyphenolic antioxidants, a naturally occurring family of oligomeric proanthocyanidins found in a wide range of fruit and vegetables.…”