Circulating Immune Complexes

Howes, Edward L.; McKay, Donald G.

doi:10.1001/archopht.1975.01010020377013

Cited by 40 publications

(3 citation statements)

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“…Both organ systems are also highly susceptible to immune complex deposition and damage that leads to fluid displacements into the interstitium. As evidence, experimentally induced type III hypersensitivity reactions in rabbits resulted in bilateral uveitis and glomerulonephritis in the same animals [2,3]. Many of the glomerulonephritidies involve systemic immune-related responses with B-lymphocyte hyperactivity or autoantibody production.…”

Section: Discussionmentioning

confidence: 99%

Choroidopathy and kidney disease: a case report and review of the literature

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Choroidopathy and kidney disease: a case report and review of the literature

et al. 2009

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“…In these cases, a hypersensitivity reaction is thought to trigger the edema of the ciliary body 8. The ciliary edema following a trauma could be caused by the synaptic ends of sympathetic nervous system that are present on the vascular walls in the ciliary body.…”

Section: Discussionmentioning

confidence: 99%

A Case Report on the Change of the Refractive Power After a Blunt Trauma

Kim

Jae

Park

2008

Korean J Ophthalmol

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PurposeTo determine the pathogenesis of transient myopia after blunt eye trauma.MethodsIn one patient, the refraction of both eyes (the left eye was injured, but the right eye was not) was measured with an autorefractometer. The cycloplegic refraction was measured at the early stage of trauma and again 3 months after the blunt eye injury. The angle and depth of the anterior chamber, the ciliary body, and the choroids were examined by ultrasound biomicroscopy (UBM) over 3 months. The depth of the anterior chamber, the thickness of the lens, and the axial length were measured by A-scan ultrasonography in both eyes. During the 3 months after the injury, we made comparisons between the menifest and the cycloplegic refractions, the depths of anterior chambers, the thickness of the lenses, the axial lengths, and the UBM-determined appearances of the angles and depths of the anterior chambers, the ciliary bodies, and the choroids in both eyes.ResultsWe suspect that the depth reduction in the anterior chamber, the increase in anterior to posterior lens diameter, and the edema in the ciliary body are all related to the change in the refractive power following the blunt trauma.ConclusionsUltrasound biomicroscopy (UBM) and ultrasonography of the anterior segment in the eye may be helpful to diagnose and confirm changes in the refractive power that occur after trauma.

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“…An equally feasible mechanism for the prolongation of an ocular inflammatory response could be the structural alteration induced by a nonspecific immunologie reaction. In the rabbit the development of systemic immune complex disease, with nonocular antigens, results in a change in ocular vascular permeability (Gamble et al, 1970 Howes andMcKay, 1975). It is conceivable that, once an animal receives this type of insult to its vascular system, the structural alteration of the ocular tissue is such that a chronic uveitis either develops or continues despite the lack of specific immune reactivity toward ocular antigens.…”

Section: Animal Models Of Noninfectious Uveitismentioning

confidence: 99%