Circulating Immune Complexes and Immunosuppressive Acidic Protein in Patients with Renal Cell Carcinoma

Iizumi, Takashi; Yazaki, Tsunetada; Kanoh, Shori; Koiso, Kenkichi; Inage, H; Kôyama, Akio; Tojo, Shizuo

doi:10.1016/s0022-5347(17)47640-3

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…IAP is a nonspecific protein for renal cell carcinomas, however, some authors reported its usefulness as a tumor marker for these tumors [10][11][12], In this study, we esti mated serum IAP levels in 143 patients. Briefly, we came to the result that serum IAP levels clearly corresponded to tumor volumes.…”

Section: Discussionmentioning

confidence: 91%

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Serum Immunosuppressive Acidic Protein as a Tumor Marker for Renal Cell Carcinoma

Igarashi

Murakami²,

Isaka³

et al. 1991

Eur Urol

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Section: Discussionmentioning

confidence: 91%

“…Some investigators stressed the suitability of IAP as a tumor marker for renal cell carcinoma [10][11][12], In this study, we tested this statement.…”

Section: Introductionmentioning

confidence: 93%

Serum Immunosuppressive Acidic Protein as a Tumor Marker for Renal Cell Carcinoma

Igarashi

Murakami²,

Isaka³

et al. 1991

Eur Urol

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“…Many investigators have reported that serum IAP is useful for monitoring the recurrence of cancer and response to therapy. 13–17 It has also been reported that the DNA content is of predictive importance; aneuploidy was found to be associated with high proliferation, local tumor invasion and poor prognosis. Furthermore, distinct chromosomal changes were also shown to be related to tumor progression in RCC.…”

Section: Introductionmentioning

confidence: 97%

Telomerase activity in human renal cell carcinoma

et al. 2000

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Purpose: Telomerase activity has been detected in a wide variety of human tumors. The present study evaluated telomerase activity in association with the acquisition of renal cell carcinoma (RCC). Methods: Telomerase activity was examined in 30 RCC and the adjacent normal kidney tissue, obtained as surgical specimens. The activity was assayed by polymerase chain reaction-based telomeric repeat amplification protocol assay. Results: Among the 30 RCC, 18 (60%) displayed telomerase activity, whereas none of the normal tissue samples exhibited it. Subdivision of the tumors according to telomerase activity did not reveal any obvious difference in distribution with regard to tumor size, stage, histocytological subtype, or DNA-ploidy. However, a statistically significant relationship was found between the frequency of telomerase-positive activity and both serum immunosuppressive acidic protein level in the patient and tumor grade (P < 0.05). There was no significant difference in the recurrent-free survival and the disease-specific survival between patients with positive telomerase activity and patients with negative activity. Conclusion:The present results indicate that telomerase activity might be related to the progression of RCC and thus a marker of malignant potential.

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“…Among patients treated at Hamamatsu University School There are no specific tumour markers for RCC, although advanced RCC is reported to be associated with an of Medicine and related hospitals from 1983 to 1995, 133 with RCC (mean age 60.1 years, sd 11.4, range increase of immunosuppressive acidic protein (IAP) [1][2][3] and IAP has been found useful for detecting the 31-84) in whom serum IAP was measured before treatment were selected. The pathological stage was recurrence of RCC after surgery [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…The serum IAP value is reported to increase in patients with RCC [2] and IAP positivity is associated with a determined and compared with the predictive value of the other four analytes. Tumour size was calculated more advanced stage and size of the cancer [1][2][3]. Elevation of IAP is reportedly useful for detecting recur-from ultrasonography, CT, MRI, or angiography in 127 patients, and was confirmed from the resected specimen.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of serum immunosuppressive acidic protein for staging renal cell carcinoma: comparison with other tumour markers

Masuda

Kurita

Suzuki

et al. 1997

British Journal of Urology

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Objective To examine the usefulness of serum immuno-122 patients, N1-3 in seven, M0 in 114 patients and M1 in 19. The area of the ROC curve for tumour size suppressive acidic protein (IAP) as a predictor for staging renal cell carcinoma (RCC), using receiverwas greatest (0.843) for staging of the local extent (T1/T2 versus T3/T4) and that for IAP was 0.714, operator characteristic (ROC) analysis, and to compare IAP with other tumour markers. similar to the values for fibrinogen, ESR and CRP. For predicting lymph node metastasis, IAP and fibrinogen Patients and methods From September 1983 to December 1995, serum IAP was measured in 133 were the most important (0.864). However, IAP alone (0.894) was the most important predictor of distant untreated patients with RCC (mean age 60.1 years, sd 11.4, range 31-84). The erythrocyte sedimentation metastasis. Using an IAP threshold of 600 mg/mL gave a high sensitivity and specificity for detecting lymph rate (ESR), the levels of fibrinogen, C-reactive protein (CRP), and a2-globulin were also measured. To comnode and distant metastasis. Conclusion IAP is a valuable predictor of lymph node pare these markers as predictors of local involvement of the renal capsule, lymph node and distant metastaand distant metastasis in patients with RCC, although it is inferior to tumour size in predicting local involvesis, the area under the corresponding ROC curve was calculated. Tumour size at the time of resection was ment of the renal capsule. The appropriate threshold value of IAP for detecting lymph node and distant added in this analysis for comparison with the levels of these tumour markers.metastasis is 600 mg/mL.

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Circulating Immune Complexes and Immunosuppressive Acidic Protein in Patients with Renal Cell Carcinoma

Cited by 15 publications

References 11 publications

Serum Immunosuppressive Acidic Protein as a Tumor Marker for Renal Cell Carcinoma

Serum Immunosuppressive Acidic Protein as a Tumor Marker for Renal Cell Carcinoma

Telomerase activity in human renal cell carcinoma

Predictive value of serum immunosuppressive acidic protein for staging renal cell carcinoma: comparison with other tumour markers

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