Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer

Gao, Yan; Zhang, Chuanqi; Liu, Yisi; Wang, Min

doi:10.5582/bst.2019.01021

Cited by 35 publications

(29 citation statements)

References 26 publications

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“…Low expression of circEXOC6B and circN4BP2L2 exhibited a tight association with OS and PFS in OvCa patients [51]. In addition, circRNA1656 was reported to be downregulated in both high-grade ovarian serous carcinoma (HGSOC) tissue and OvCa cell lines and correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage of HGSOC, suggesting its potential to serve as a novel tumor marker for HGSOC [52].…”

Section: Circrnas Function As Diagnostic and Prognostic Biomarkersmentioning

confidence: 97%

The emerging roles of circular RNAs in ovarian cancer

et al. 2020

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Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess several specific molecular functions, including regulating gene transcription and translation, acting as miRNA sponges, and interacting with functional proteins. Ovarian cancer (OvCa) is one of the most aggressive malignant diseases affecting the lives of thousands of women worldwide, and the majority of OvCa cases are diagnosed at advanced stages. Accumulating evidence has revealed the significant roles of circRNAs in the occurrence and progression of OvCa, indicating the function of circRNAs as promising biomarkers and their therapeutic relevance in this disease. This review aims to summarize the mechanisms by which circRNAs mediate OvCa progression as well as their diagnostic and prognostic values in OvCa.

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Section: Circrnas Function As Diagnostic and Prognostic Biomarkersmentioning

confidence: 97%

The emerging roles of circular RNAs in ovarian cancer

et al. 2020

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“…Expression profiling studies and bioinformatics analysis have revealed significant changes in circRNA expression between OC tissues and normal ovarian tissues [116,117], between miliary-type OC and non-miliary OC [118], between serum samples from OC patients and those samples from healthy controls [119], between primary and metastatic sites of OC [120], and between OC cells and non-malignant human ovarian surface epithelial cells [62]. The expression and mechanisms of circRNAs in OC are presented in Table 2 and their biological roles are shown in Figure 4.…”

Section: Circrnas In Ocmentioning

confidence: 99%

“…Early studies have provided evidence that circRNAs could be used as biomarkers in distinguishing cancer tissues from normal tissues and predicting the progression and prognosis, and assessment of response to therapy in many cancer types [15]. Dysregulation of circRNAs has been reported to be closely related to the clinicopathological characteristics of patients with CC, OC and EC [79,80,94,117,149,153]. In addition, levels of some circRNAs have been associated with survival times in patients with CC and OC [78,80,141,142,[157][158][159][160].…”

Section: Circrnas As Potential Biomarkers In Gynecological Cancersmentioning

confidence: 99%

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

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Circular RNAs (circRNAs) are covalently closed, endogenous non-coding RNAs and certain circRNAs are linked to human tumors. Owing to their circular form, circRNAs are protected from degradation by exonucleases, and therefore, they are more stable than linear RNAs. Many circRNAs have been shown to sponge microRNAs, interact with RNA-binding proteins, regulate gene transcription, and be translated into proteins. Mounting evidence suggests that circRNAs are dysregulated in cancer tissues and can mediate various signaling pathways, thus affecting tumorigenesis, metastasis, and remodeling of the tumor microenvironment. First, we review the characteristics, biogenesis, and biological functions of circRNAs, and describe various mechanistic models of circRNAs. Then, we provide a systematic overview of the functional roles of circRNAs in gynecological cancers. Finally, we describe the potential future applications of circRNAs as biomarkers for prognostic stratification and as therapeutic targets in gynecological cancers. Although the function of most circRNAs remains elusive, some individual circRNAs have biologically relevant functions in cervical cancer, ovarian cancer, and endometrial cancer. Certain circRNAs have the potential to serve as biomarkers and therapeutic targets in gynecological cancers.

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“…[8][9][10] A previous study showed that circ_0002755 could act as a biomarker in high-grade serous ovarian cancer. 11 Nevertheless, the role and function of circ_0002755 in glioma is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

<p>Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis</p>

Xia

Guan³

et al. 2020

CMAR

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Background: Glioma is a common malignant tumor worldwide. Sevoflurane (Sev) has been reported to inhibit the metastasis of glioma cells, but the underlying molecular mechanism needs further exploration. Methods: Cell Counting Kit-8 (CCK8) assay was used to check cell viability. Flow cytometry assay was hired to check cell apoptosis. The protein levels of B-cell lymphoma-2 (Bcl-2), BCL2-Associated X (Bax), hexokinase 2 (HK2) and magnesium transporter 1 (MAGT1) in samples were measured by Western blot. The abilities of cell migration and invasion were estimated by transwell assay. Glucose colorimetric assay kit and lactate colorimetric assay kit were used to check glucose consumption and lactate production, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the levels of circular RNA (circRNA) circ_0002755 (also known as the circRNA1656) and microRNA (miR)-628-5p in samples. The interaction between miR-628-5p and circ_0002755 or MAGT1 was predicated by starBase, which was verified by the dual-luciferase reporter assay. Xenograft tumor model was established to explore the biological role of circ_0002755 in vivo. Results: Sev inhibited cell viability, migration, invasion and promoted cell apoptosis, and also reduced glucose consumption and lactate production. Circ_0002755 was significantly upregulated in glioma tissues and cells, while its level was notably declined under Sev treatment. Besides, overexpression of circ_0002755 overturned Sev-mediated inhibitory effect on glioma progression. Further research indicated that circ_0002755 targeted miR-628-5p, and miR-628-5p targeted MAGT1, and Sev modulated glioma progression via circ_0002755/miR-628-5p/MAGT1 axis. Moreover, Sev hindered tumor growth in vivo. Conclusion: Sev mediated glioma progression via circ_0002755/miR-628-5p/MAGT1 axis.

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Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer

Cited by 35 publications

References 26 publications

The emerging roles of circular RNAs in ovarian cancer

The emerging roles of circular RNAs in ovarian cancer

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

<p>Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis</p>

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