Cicatrização: conceitos atuais e recursos auxiliares - Parte I

Mandelbaum, Samuel Henrique; Santis, Érico Pampado Di; Mandelbaum, Maria Helena Santana

doi:10.1590/s0365-05962003000400002

Cited by 155 publications

(197 citation statements)

References 19 publications

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“…This study allowed to observe that neutrophils were present on the surgical wound up to the 21st day, which is a longer period than that described in the literature [10][11][12][13]22 , indicating persistence of the acute inflammatory process. Macrophages were observed on the 2nd day, according to literature data [10][11][12][13]16,22 , reaching their highest levels after the 7th day and remaining high until the end of the study period.…”

Section: Discussionmentioning

confidence: 70%

“…The fibroplasia process consists of a harmonious and coordinated sequence of cellular and molecular events which interact to promote the repair and reconstruction of damaged tissue [10][11][12][13] . Its extent depends on the level of inflammatory activity, one of the healing stages [14][15][16] , and is a prerequisite for the reconstruction of a mechanically stable abdominal wall.…”

Section: Introductionmentioning

confidence: 99%

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Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

et al. 2009

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RESUMOObjetivo: Avaliar o tempo de fibroplasia em tela de polipropileno na correção de hérnias incisionais da parede abdominal, em ratos, através da quantidade de colágeno, correlacionando-o com a resposta inflamatória local. Métodos: Trinta e seis ratos machos da linhagem Wistar foram submetidos à ressecção longitudinal de um segmento músculo-aponeurótico e peritoneal (3x2 cm) da parede abdominal, seguida por reforço com tela de polipropileno, em forma de ponte sobre a aponeurose. Os animais foram distribuídos em seis grupos, de acordo com o tempo de fibroplasia a ser estudado (1, 2, 3, 7, 21 e 30 dias de pós-operatório). Após os prazos estabelecidos para estudo da fibroplasia, os animais foram submetidos à eutanásia, e a área de fixação da tela de polipropileno foi avaliada histologicamente quanto à reação inflamatória e à percentagem de colágeno pela técnica videomorfométrica assistida por computador. Resultados: Houve aparecimento de colágeno total junto à tela no 3º dia pós-implante, com aumento progressivo na sua proporção em todos os dias subseqüentes até o 21º dia, quando atingiu sua proporção máxima (p<0,001). A partir do dia 3, o colágeno III sofreu um aumento progressivo até o dia 21, quando atingiu sua proporção máxima (p<0,001), e no 30º dia apresentou uma redução significativa (p<0,001). O colágeno tipo I surgiu entre o 7º e o 21º dia, apresentou sua máxima proporção no 21º dia e manteve-se inalterado até o final do período de observação. A relação colágeno tipo I/tipo III aumentou progressivamente e inverteu-se no 30º dia de observação (p<0,001). Os neutrófilos foram identificados no 1º dia pós-implante, mantendo-se junto à tela até o 21º dia. Os macrófagos, gigantócitos e linfócitos foram identificados no 2º dia. Trinta dias após a implantação da tela, desapareceram os neutrófilos e mantiveram-se estáveis as proporções de macrófagos, gigantócitos e linfócitos (p<0,001). Conclusões: Os resultados do presente estudo evidenciaram a presença de colágeno no 3º dia pós-implante, com predomínio do colágeno tipo I ao final do período de observação. O prolongamento da resposta inflamatória da cicatrização e a persistência do processo inflamatório crônico junto à tela não interferiram no tempo da fibroplasia. Descritores: Parede Abdominal. Colágeno. Hérnia. Telas Cirúrgicas. Polipropilenos. Neutrófilos. Ratos. ABSTRACT Purpose:This study assessed the collagen deposition and correlated it with local inflammatory responses to evaluate the length of time required for fibroplasia when polypropylene meshes are used to repair incisional abdominal wall hernias in rats. Methods: Thirty-six male Wistar rats underwent longitudinal resection of a peritoneal and musculoaponeurotic tissue segment (3x2 cm) of the abdominal wall followed by defect reconstruction with polypropylene mesh bridging over aponeurosis. The animals were divided into 6 groups according to the time points for the analysis of fibroplasia: 1, 2, 3, 7, 21 and 30 days post-implantation. Animals were sacrificed at each time point, and the site where th...

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

et al. 2009

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“…This check was necessary, since the process of wound contraction is the fourth phase of the healing process and is the centripetal movement of the edges 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Another important finding was the presence of macrophages, responsible for the giant cell reaction 7 . Lymphocytes, by its lymphokines, have great influence on macrophages.…”

Section: Discussionmentioning

confidence: 99%

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A utilização da Pfaffia glomerata no processo de cicatrização de feridas da pele

Silva

Ribas-Filho

Malafaia

et al. 2010

ABCD, arq. bras. cir. dig.

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-Background -When tissue loss occurs in the skin comes the need for reconstruction and many devices and medication are proposed to increase the healing process. The use of herbal medicine, such as Pfaffia glomerata, aims to play an active role in the scar formation. Aim -To evaluate the results of the use of Pfaffia glomerata on healing process of surgical wounds in rats. Methods -A total of 40 rats, which were held surgical wounds with a punch of 3 mm in diameter at the upper right back where no substance was applied and another in the lower region, where the herbal extract was used. They were divided into four subgroups of 48 hours, one, two and three weeks in relation to sacrifice. Measures were taken on the circumference to analyze the macroscopic contraction of the wound. Microscopic data were analyzed using the hematoxylin-eosin staining to verify the inflammatory process; immunohistochemistry, factor VIII, to observe the vascular density, and Masson trichrome to study fibrosis. Results -Macroscopic plant group achieved better results than the control group. The analysis of factor VIII showed statistical significance in a week of herbal medicine. In fibrosis, it was found that during the 48 hours the control group showed 70% of cases with minimal fibrosis, whereas the plant, 90%. In one week, the control group showed 10% of cases with no fibrosis, 60% with minimal fibrosis and 30% with moderate fibrosis, while the group plant showed 70% of cases with minimal fibrosis and 30% with moderate fibrosis. In the period of two weeks, the control group maintained 60% of cases with minimal fibrosis and increased to 40% of those with moderate fibrosis, while the plant maintained its group average presented in the previous group. In three weeks both groups, control and plan, kept the percentages presented in the previous period. Conclusion -In relation to wound contraction, plant group showed better results than the control group. In regard to histological analysis, HE staining showed a greater presence of inflammation in the animals of control groups. The immunohistochemical technique showed a vascular density, higher in the plant during the period of one week and Masson's trichrome staining showed no significant changes RESUMO -Racional -Quando ocorre perda tecidual na pele surge a necessidade de reconstituir-se o tecido lesionado e atualmente cada vez mais surgem artifícios que se propõem neoformá-lo. O uso de fitoterápicos, como a Pfaffia glomerata, tem a finalidade de buscar nestes produtos princípios ativos que desempenhem efetivo papel no processo de cicatrização. Objetivo -Avaliar os resultados da utilização da Pfaffia glomerata na cicatrização de feridas cirúrgicas em ratos. Métodos -Foram utilizados 40 ratos, nos quais realizaram-se feridas cirúrgicas com punch de 3 mm de diâmetro no dorso da parte superior direita onde nenhuma substância foi aplicada e nesses mesmos animais foram também realizadas feridas cirúrgicas na região inferior, onde foi aplicado o extrato do fitoterápico. Foram divididos em...

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Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Pereira

Cury

Nunes

et al. 2023

Chemistry & Biodiversity

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In southern Brazil, the biodiversity is great and the traditional use of medicinal plants for wound healing has been documented in ethnobotanical studies and pharmacological studies have assessed their wound properties and phytochemistry. Therefore, this study evaluated ethnobotanical surveys regarding medicinal plants used in southern Brazil for wound healing and studies about the healing properties of these plants published between 2000 and 2022. To retrieve articles related to the study, Web of Science, PubMed (NLM), Open Access Journals, Scielo, Lilacs, and Google Scholar, with keywords including medicinal plants, wound healing, and South of Brazil, have been used. As a result, 73 medicinal plants belonging to 39 families were found in ethnobotanical surveys as a traditional resource used for wound healing in southern Brazil, 15 of which were cited more than once. Besides, 14 of these 15 plants were also used as healing agents worldwide. The most cited plant with healing actions in southern Brazil was Symphytum officinale L. (comfrey). From 2000 to date, 44 articles scientifically demonstrated the wound‐healing effects of the southern Brazilian plants found in ethnobotanical surveys reviewed. The folk medicine of southern Brazil presents a variety of medicinal plants for wound‐healing purposes, and scientific data were found for some of those plants. However, the wound‐healing properties of many plants have yet to be investigated, and the current literature still needs more phytochemical information about the plants studied. Aside from this, the future focus should be on the standardization of herbal extracts, and further research is required to investigate the pharmacological mechanisms. Clinical research in this area remains in its infancy and warrants more robust further clinical studies.

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Cicatrização: conceitos atuais e recursos auxiliares - Parte I

Cited by 155 publications

References 19 publications

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

A utilização da Pfaffia glomerata no processo de cicatrização de feridas da pele

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

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