Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

Vaz, Marta Regina Cezar; Krebs, Rodrigo K.; Trindade, Eduardo Neubarth; Trindade, Manoel Roberto Maciel

doi:10.1590/s0102-86502009000100005

Cited by 36 publications

(33 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hematoxylin-eosin staining was used to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes, according to protocol previous described 12 . A single pathologist, blinded to treatments, analyzed slides.…”

Section: Histological Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Utiyama

Rosa²,

Andres³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia. METHODS:Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro ® mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes. RESULTS:No significant difference was seen among groups in adherences, fibrosis, giant cells, macrophages, neutrophils or lymphocytes (p>0.05). Mesh shrinkage was observed in all groups, but also no difference was observed between polypropylene and Ultrapro mesh (7.0±9.9 vs. 7.4±10.1, respectively, p=0.967). Post-operatory complications included fistula, abscess, dehiscence, serohematic collection and reherniation, but with no difference among groups (p=0.363). CONCLUSION:There is no difference between polypropylene (high-density) and Ultrapro ® (low-density) meshes at 21 days after surgery in extraperitoneal use in rats, comparing inflammatory response, mesh shortening, adhesions or complications.

show abstract

Section: Histological Evaluationmentioning

confidence: 99%

“…Adhesions were analyzed by a classification proposed previosly 12,13 . Most authors found that the occurrence of adhesions increased with the use of polypropylene 3,14 and Ultrapro…”

Section: Complications No Meshmentioning

confidence: 99%

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Utiyama

Rosa²,

Andres³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…The larger the diameter of the pores, the larger the inflammatory cells will be, and the healing process will be faster. The tissue reaction usually begins with a considerable inflammatory process in the entire area of the mesh 8 .…”

mentioning

confidence: 99%

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

et al. 2014

View full text Add to dashboard Cite

PURPOSE:To compare the inflammatory reaction and the growing resistance of the abdominal wall with the use of poliglecaprone meshes and polypropylene meshes associated with poliglecaprone in the correction of abdominal defects. METHODS:Seventy-seven Wistar rats were divided into three groups: CG (non-operated animals: EG (polypropylene mesh) and UG (polypropylene and poliglecaprone mesh). A muscular and aponeurotic defect was formed and treated according to the group.Evaluations were made after 4, 7, 14, 28 and 56 days. The resistance and inflammatory pattern were studied. RESULTS:There was a gradual and significant gain in resistance, regularly in the EG and irregularly in the UG, which was lower on the 14 th day (p=0.008). The inflammatory reaction was acute and more intense in the UG on the fourth day. At all other times, the inflammatory pattern was acute to chronic, similar in both groups, with minimum intensity on the 56 th day. CONCLUSION:The greater resistance offered by the polypropylene mesh was regular and ascending, stabilizing on the 28 th day, while that of the polypropylene/poliglecaprone was not even. In the end, the resistances were similar. The inflammatory response was greater in the UG on the fourth day and similar at all other times.

show abstract

“…Other studies also demonstrated an early deposition of total collagen, decreasing after the twenty-first day 20 .…”

Section: Histological Studymentioning

confidence: 79%

Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal®) coated polypropylene mesh in rabbits

et al. 2013

View full text Add to dashboard Cite

PURPOSE:To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal ® ) in contact with small bowel in an experimental model in rabbits. METHODS:Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks.The right mesh was protected with Coseal ® spray (Group 1) and the left mesh received no treatment after implantation (Group 2).Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test. RESULTS:There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups. CONCLUSION:Polypropylene mesh coated with Coseal ® showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.

show abstract

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

Cited by 36 publications

References 26 publications

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal®) coated polypropylene mesh in rabbits

Contact Info

Product

Resources

About