Introdução: A crise pelo novo Coronavírus (SARS-CoV-2) tem impactado diversos setores, dentre eles o da educação superior, pois as atividades realizadas dentro da universidade estão, desde março de 2020, sendo remanejadas e readaptadas para o modelo on-line, dentre elas a extensão universitária. Objetivo: O presente artigo temobjetivo d um projeto de extensão universitária desenvolvido para estimular a adoção de hábitos alimentares saudáveis e que migrou suas atividades para o ambiente virtual, mostrando como foram os desafios e adaptações nesse novo cenário global. Metodologia: Trata-se de um estudo descritivo, do tipo relato de experiência. As atividades adaptadas à nova realidade que serão aqui mencionadas ocorreram no primeiro semestre de 2020, iniciando no mês de maio e finalizando em julho. As postagens para as redes sociais Facebook® e Instagram® foram realizadas uma vez por semana, por dois acadêmicos do curso de Nutrição e bolsistas do projeto, tendo sempre o auxílio das professoras responsáveis. Resultados: A utilização das redes sociais Facebook® e Instagram® ajudaram nosso projeto a desempenhar suas atividades de forma remota e obter um alcance maior de pessoas beneficiadas com as publicações. Conclusão: Apesar das dificuldades iniciais de planejamento de cronograma, temas abordados e o alcance do público alvo, conseguimos reestruturar bem o projeto ao novo formato e nos surpreendemos com o alcance das publicações e a capacidade de influenciar positivamente as vidas das pessoas, buscando trazer assuntos pertinentes e com embasamento científico, para assim, mesmo que remotamente, tentar melhorar do bem-estar da população. Palavras-Chave: Relações Comunidade-Instituição, Pandemias, Prevenção de Doenças.
The hydroalcoholic extract of B. dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. Colitis was induced in Swiss mice by oral dextran sulfate sodium (DSS) administration for five days. The mice received vehicle (10 ml/kg), HEBD (3, 30, or 300 mg/kg), or p-coumaric acid (15 mg/kg) orally, once a day for twelve days. Behavioral tests were performed on the 11th and 12th days after the beginning of the treatments. Moreover, the colon, cortex, and hippocampus were collected to analyze oxidative and inflammatory parameters. The treatment with HEBD (300 mg/Kg), but not p-coumaric acid, showed decreased disease activity index (DAI) values compared to the vehicle group and partially preserved the villi architecture and mucin levels. Furthermore, the HEBD increased the antioxidant defenses in the colon and hippocampus and reduced the myeloperoxidase activity and IL-6 levels in the colon from colitis mice. Colitis mice treated with HEBD did not show depressive-like behavior in the tail suspension test. HEBD reduced colon inflammation, while it maintains antioxidant defenses and mucin levels in this tissue. It may reduce neuropsychiatric comorbidities associated with colitis through its antioxidant effects.
In southern Brazil, the biodiversity is great and the traditional use of medicinal plants for wound healing has been documented in ethnobotanical studies and pharmacological studies have assessed their wound properties and phytochemistry. Therefore, this study evaluated ethnobotanical surveys regarding medicinal plants used in southern Brazil for wound healing and studies about the healing properties of these plants published between 2000 and 2022. To retrieve articles related to the study, Web of Science, PubMed (NLM), Open Access Journals, Scielo, Lilacs, and Google Scholar, with keywords including medicinal plants, wound healing, and South of Brazil, have been used. As a result, 73 medicinal plants belonging to 39 families were found in ethnobotanical surveys as a traditional resource used for wound healing in southern Brazil, 15 of which were cited more than once. Besides, 14 of these 15 plants were also used as healing agents worldwide. The most cited plant with healing actions in southern Brazil was Symphytum officinale L. (comfrey). From 2000 to date, 44 articles scientifically demonstrated the wound‐healing effects of the southern Brazilian plants found in ethnobotanical surveys reviewed. The folk medicine of southern Brazil presents a variety of medicinal plants for wound‐healing purposes, and scientific data were found for some of those plants. However, the wound‐healing properties of many plants have yet to be investigated, and the current literature still needs more phytochemical information about the plants studied. Aside from this, the future focus should be on the standardization of herbal extracts, and further research is required to investigate the pharmacological mechanisms. Clinical research in this area remains in its infancy and warrants more robust further clinical studies.
Sonchus oleraceus L. is an edible and medicinal plant used to treat stomachache and gastric ailments around the world. Thus, this study aimed to determine the gastroprotective mode of action of hydroalcoholic extract of S. oleraceus (HES). Mice were treated with HES before induction of gastric ulceration by ethanol/HCl. The area and histological appearance of ulcers were quantified, and mucus was measured histochemically. The effects of HES on inflammatory and oxidative markers were assessed in the ulcerated tissue. In addition, we investigated the gastric acid antisecretory activity of HES in pylorus-ligated rats. Chemical analyses of HES and its antioxidant activity were also performed in vitro. The HES (30 or 300 mg/kg) reduced the ulceration by 71.5 and 76.2%, respectively, compared with vehicle ( p < 0.001 ), and the histological analysis confirmed the macroscopic results with elevation in mucin levels by 361.4 and 477.5%, respectively, compared with vehicle ( p < 0.001 ). Moreover, the gastroprotection was accompanied by increases in GSH levels and in SOD, CAT, and GST activities; in parallel to a reduction in MPO activity and TNF levels. Furthermore, HES reduced the total acidity, and pepsin activity of the gastric juice of rats by 61 and 63%, respectively, compared to the vehicle. Phytochemical analysis indicated that luteolin-7-O-β-D-glucoside is the main active compound annotated in HES. Was also found that HES scavenged the DPPH radical with an IC50 of 15.41 μg/mL. In conclusion, the gastroprotective effects of HES involve reductions in oxidative stress and inflammatory injury, in conjunction with an increase in mucus layer and inhibition of gastric secretion. This study advances in elucidating the modes of the antiulcer potential of S. oleraceus and contributes to the prospection of new gastroprotective molecules.
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