A utilização da Pfaffia glomerata no processo de cicatrização de feridas da pele

Abstract

-Background -When tissue loss occurs in the skin comes the need for reconstruction and many devices and medication are proposed to increase the healing process. The use of herbal medicine, such as Pfaffia glomerata, aims to play an active role in the scar formation. Aim -To evaluate the results of the use of Pfaffia glomerata on healing process of surgical wounds in rats. Methods -A total of 40 rats, which were held surgical wounds with a punch of 3 mm in diameter at the upper right back where no substance was applied and another in the lower region, where the herbal extract was used. They were divided into four subgroups of 48 hours, one, two and three weeks in relation to sacrifice. Measures were taken on the circumference to analyze the macroscopic contraction of the wound. Microscopic data were analyzed using the hematoxylin-eosin staining to verify the inflammatory process; immunohistochemistry, factor VIII, to observe the vascular density, and Masson trichrome to study fibrosis. Results -Macroscopic plant group achieved better results than the control group. The analysis of factor VIII showed statistical significance in a week of herbal medicine. In fibrosis, it was found that during the 48 hours the control group showed 70% of cases with minimal fibrosis, whereas the plant, 90%. In one week, the control group showed 10% of cases with no fibrosis, 60% with minimal fibrosis and 30% with moderate fibrosis, while the group plant showed 70% of cases with minimal fibrosis and 30% with moderate fibrosis. In the period of two weeks, the control group maintained 60% of cases with minimal fibrosis and increased to 40% of those with moderate fibrosis, while the plant maintained its group average presented in the previous group. In three weeks both groups, control and plan, kept the percentages presented in the previous period. Conclusion -In relation to wound contraction, plant group showed better results than the control group. In regard to histological analysis, HE staining showed a greater presence of inflammation in the animals of control groups. The immunohistochemical technique showed a vascular density, higher in the plant during the period of one week and Masson's trichrome staining showed no significant changes RESUMO -Racional -Quando ocorre perda tecidual na pele surge a necessidade de reconstituir-se o tecido lesionado e atualmente cada vez mais surgem artifícios que se propõem neoformá-lo. O uso de fitoterápicos, como a Pfaffia glomerata, tem a finalidade de buscar nestes produtos princípios ativos que desempenhem efetivo papel no processo de cicatrização. Objetivo -Avaliar os resultados da utilização da Pfaffia glomerata na cicatrização de feridas cirúrgicas em ratos. Métodos -Foram utilizados 40 ratos, nos quais realizaram-se feridas cirúrgicas com punch de 3 mm de diâmetro no dorso da parte superior direita onde nenhuma substância foi aplicada e nesses mesmos animais foram também realizadas feridas cirúrgicas na região inferior, onde foi aplicado o extrato do fitoterápico. Foram divididos em...

Antioxidant potential of Pfaffia glomerata and Arrabidaea chica extracts combination

“…Pedersen (Amaranthaceae), known as Brazilian ginseng, is widely used in Brazil to treat various pathological conditions (Franco et al, 2021). Studies report that P. glomerata extract is widely used in the pharmaceutical industry, due to its antimicrobial, anti-rheumatic, anti-tumor, anti-diabetic properties, in addition to actions such as anti-inflammatory, healing and antioxidant effect (Silva et al, 2010;Oliveira and Sakai, 2020;Souza, Fonseca, Ferrari, and Felipe, 2021).…”

Deleterious effects of Pfaffia glomerata (Spreng.) Pedersen hydroalcoholic extract on the seminiferous epithelium of adult Balb/c mice

“…2 Pfaffia glomerata (Amaranthaceae) commonly known as 'fáfia' or 'Brazilian ginseng' is one of the species widely used in Brazilian traditional medicine as a potent stimulant and aphrodisiac. [3][4][5] Its roots are rich in triterpenoid saponins with important pharmacological activities, being the β-ecdysone (a steroidal saponin) its main component. 6 In addition, it has been proven to be a potential anti-inflammatory and analgesic species, 4 employed in skin wound treatments 5,7 and to ameliorate gradual memory loss.…”

“…[3][4][5] Its roots are rich in triterpenoid saponins with important pharmacological activities, being the β-ecdysone (a steroidal saponin) its main component. 6 In addition, it has been proven to be a potential anti-inflammatory and analgesic species, 4 employed in skin wound treatments 5,7 and to ameliorate gradual memory loss. 8 Spermatogenesis takes place in the epithelium of the seminiferous tubules, being a process of intense cell division leading to sperm production.…”

Effect of Carapa guianensis Aublet (Andiroba) and Orbignya phalerata (Babassu) in colonic healing in rats

“…The interest in wound healing began in antiquity, with records dating back to 3000-2500 b. C. Among them, honey-based, grease, and flax strings are mentioned as medicine that constituted Egyptian pharmacopoeia 3,4 .…”