Chronic sinusitis pathophysiology: The role of allergy

Kennedy, Joshua L.; Borish, Larry

doi:10.2500/ajra.2013.27.3906

Cited by 52 publications

(42 citation statements)

References 66 publications

(86 reference statements)

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“…In the present study, 15 (22.1%) CRSwNP patients showed atopy, representing a higher incidence than that for healthy people. This finding suggests that atopy remains a common pathogenesis of CRSwNP, a viewpoint that is shared with two previous studies (20,21).…”

Section: Discussionsupporting

confidence: 73%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) patients had systemic allergies. On the basis of the ECP/MPO ratio, the patients were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/MPO ratio was 0.572, with a notable bias toward neutrophilic inflammation. The supernatant ECP and MPO levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and SEB levels compared with the control group. Thus, it may be concluded that allergy is a common pathogenesis of CRSwNP, and neutrophilic inflammation is present in most Chinese CRSwNP patients. Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP patients. Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP patients.

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Section: Discussionsupporting

confidence: 73%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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“…The average age of onset in all individuals is 42 years, and disease is uncommon under the age of 20. In contrast, neutrophilic CRS, seen in individuals with cystic fibrosis, is IL‐8 driven, and is common under the age of 20 …”

Section: Discussionmentioning

confidence: 99%

“…There is a common association with asthma and atopy. Characteristic histological features include oedema, eosinophilic infiltration and basement membrane thickening . Recently, we observed the presence of clusters of RDH (S100‐ and CD68‐positive, CD1a‐negative) in 10 individuals with otherwise characteristic ECR.…”

Section: Introductionmentioning

confidence: 89%

Rosai–Dorfman‐type histiocytes occur in eosinophilic chronic rhinosinusitis and potentially play a role in disease initiation and persistence

Wilsher¹,

Bonar

2016

Histopathology

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“…Not surprisingly, these cytokines are involved in stimulation of cell growth, proliferation, and differentiation, and a number of key processes linked with allergy and asthma, such as chemo-attraction of inflammatory cells (e.g. eosinophils) and tissue remodeling 24,25 . Also, more differences were observed in the adenoids compared to the sinuses, perhaps reflecting the major role of the adenoids in regulating immune function.…”

Section: Discussionmentioning

confidence: 99%

Sinus and adenoid inflammation in children with chronic rhinosinusitis and asthma

Anfuso¹,

Ramadan²,

Terrell³

et al. 2015

Annals of Allergy, Asthma & Immunology

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Chronic sinusitis pathophysiology: The role of allergy

Abstract: Background: Chronic hyperplastic eosinophilic sinusitis (CHES) is an inflammatory disease characterized by eosinophil infiltration

Cited by 52 publications

References 66 publications

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Rosai–Dorfman‐type histiocytes occur in eosinophilic chronic rhinosinusitis and potentially play a role in disease initiation and persistence

Sinus and adenoid inflammation in children with chronic rhinosinusitis and asthma

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